Serum β<sub>1</sub>A (β<sub>1</sub>C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findings

Miyasato, Fujihiko; Pollak, Victor E.; R, Barcelo

doi:10.1002/art.1780090206

Cited by 17 publications

(3 citation statements)

References 14 publications

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“…It is well known that the determination of B,, levels can aid in the diagnosis (14). This was the case, for example, with patient 'TD ( Fig.…”

Section: Discussionmentioning

confidence: 89%

“…Serum complement levels may be decreased in acute post-streptococcal glomerulonephritis (APGN) (5,6,7,11,12,15,21), in membranoproliferative glomerulonephritis (MPGN) (1,5,6,8,15,18,19,20) and in glomerulonephritis associated with systemic lupus erythematosus (SLE) (2,5,7,10,12,14). The determination of total haemolytic complement (C'I150) is rather impracticable for clinical use.…”

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confidence: 99%

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CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

Arisz

Brentjens

Hem

et al. 1972

Journal of Internal Medicine

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Serum levels of B1A‐globulin, a metabolic product of the third component of complement, have been investigated by a simple immunochemical method in a group of adult patients with renal disease. A renal biopsy was performed in 100 of 105 adult patients with primary renal disease and in 27 of 51 patients with secondary or other renal disease, enabling classification on histological grounds. Decreased B1A levels were found in acute poststreptococcal glomerulonephritis (APGN) and in some patients with membrano‐proliferative glomerulonephritis (MPGN) and glomerulonephritis associated with systemic lupus erythematosus (SLE). In these three categories of patients B1E‐globulin, the fourth component of complement, was also determined by the same simple immunochemical method. In APGN B1A‐globulin rises to normal levels in 1–4 months after the onset of the disease. The B1E‐globulin is occasionally decreased at a very early stage in APGN, and then returns rapidly to normal levels. In MPGN the B1A level may be constantly low for many years. Some patients, however, demonstrate a change in the level with time. The B1E level is usually normal in this group. A number of patients with MPGN had, at least on a single determination, normal B1A levels. In SLE glomerulonephritis decreased levels of both complement components are found, the B1E‐globulin usually being diminished to a greater extent than the B1A‐globulin. Occasionally only the B1E level is low, which could mean that the determination of B1E‐globulin is of greater significance for the diagnosis of SLE than the determination of B1A‐globulin. Two patients with SLE showed a parallel increase in both complement factors during longterm treatment with large doses of corticosteroids. SLE differs in this respect from APGN, and this suggests a different manner of complement activation. From this group of adult patients it may be concluded that the findings relating to serum B1A levels in children with renal disease are also applicable to adults. In addition, the determination of B1A‐ and B1A‐levels by a simple technique is of value in the differential diagnosis of patients with glomerulonephritis.

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“…It is well known that the determination of B,, levels can aid in the diagnosis (14). This was the case, for example, with patient 'TD ( Fig.…”

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

Arisz

Brentjens

Hem

et al. 1972

Journal of Internal Medicine

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“…Also, when vaccinees at a later date underwent natural infection, they developed serious lower respiratory tract disease of the type characteristically seen during the first few months of life (7-9). A decrease in serum complement has been demonstrated in several diseases believed to result from the toxic effect of antigen-antibcody complexes [Type I11 immune reaction as classified by Gel1 and Coombs (10)(11)(12)(13) 3. This is thought to reflect fixation and utilizatlion of complement by antigen-antibody complexes.…”

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confidence: 99%

Serum Complement in Acute Bronchiolitis

Ana¹,

Arrobio²,

Kim³

et al. 1970

Experimental Biology and Medicine

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Zur Klinik und Prognose der Nierenmanifestationen bei Lupus erythematodes

1970

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Serum β₁A (β₁C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findings

Cited by 17 publications

References 14 publications

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

Serum Complement in Acute Bronchiolitis

Zur Klinik und Prognose der Nierenmanifestationen bei Lupus erythematodes

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Serum β1A (β1C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findings

Cited by 17 publications

References 14 publications

CLINICAL VALUE OF SERUM B1A‐ AND B1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

CLINICAL VALUE OF SERUM B1A‐ AND B1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

Serum Complement in Acute Bronchiolitis

Zur Klinik und Prognose der Nierenmanifestationen bei Lupus erythematodes

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Product

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Serum β₁A (β₁C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findings

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE