SERUM α₂‐MACROGLOBULIN LEVELS IN TUBEROSE SCLEROSIS

Plasma Acute‐phase Reactant Proteins in Tuberose Sclerosis

“…In Table 2 the number of tuberose sclerosis subjects found with significant deviations from the normal mean (above, or in the case of transferrin below 2SD of the normal mean) are given, together with the frequency for each of the acute-phase proteins in which others were found to be outside the normal range. Inrltided in Table 2 are the data reported on the ag-macroglobulin in the same sample (Rundle and Atkin, 1976). Of the fifty-four subjects investigated, only thirteen failed to show any abnormal levels in the acute-phase proteins, of the forty-one cases with abnormal levels t\\ enty-seven (65.8 per cent) showed abnormalities in more than one parameter.…”

“…In our previous communication (Rundle and Atkin, 1976) we were able to show that the plasma levels of the ag-macroglobuUns in a number of subjects with ttiberose sclerosis were increased when compared to a similar group of institutionalised control subjects. At that time we were only able to suggest that the mechanism involved may be similar to that of the response of the so-called acute phase reactants to injury and to the presence of neoplastic tissue.…”

“…The fifty-four subjects with tuberose sclerosis and the control subjects were described in the previous communication (Rundle and Atkin, 1976). Affected subjects were diagnosed by the presence of the triad of symptoms of mental subnormality, epilepsy and sebaceous adenoma.…”