Serum Zinc in Patients with Cystic Fibrosis at Diagnosis and After One Year of Therapy

Biervliet, Stéphanie Van; Biervliet, Jean-Pierre Van; Robberecht, Eddy

doi:10.1385/bter:112:3:205

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…Several studies evaluating the Zn status of CF patients were based on serum Zn concentrations. The results, however, are contradictory [3][4][5][6][7] . Since symptoms of Zn deficiency are nonspecific and overlap those of CF, detection of clinical deficiency is difficult.…”

Section: Introductionmentioning

confidence: 98%

“…Earlier we reported the results of a cross-sectional examination of our CF population [4,16] . Among them we identified a cohort of severely affected children, presenting severe pancreatic insufficiency, loss of appetite, low nutritional intake and stunted growth combined with low serum Zn values [4,16] .…”

Section: Introductionmentioning

confidence: 99%

“…Among them we identified a cohort of severely affected children, presenting severe pancreatic insufficiency, loss of appetite, low nutritional intake and stunted growth combined with low serum Zn values [4,16] . No relation with the genotype was obvious, but very low serum Zn concentrations were a main characteristic of pancreatic insufficiency.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Zinc Supplements in Cystic Fibrosis Patients

et al. 2008

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Aim: To study the effect of Zn supplements in cystic fibrosis (CF) on disease evolution. Methods: A retrospective study of all CF patients treated with Zn supplements (January 2002 to December 2004). Data from patient files for the year before and the first year of supplementation were compared. The controls were CF patients with normal serum Zn and without Zn supplementation. Results: 21 patients (7 females), median age 8.9 (interquartile range 13.1) years, received 5 mg/kg Zn sulfate/day (maximum 150 mg). The number of infections decreased from 3 (1.25) to 2 (2.0) (tied p < 0.02) and the forced expiratory volume in 1 s (FEV₁) increased from 72.0 (38.4) to 76.5 (52)% (p < 0.02). Energy intake improved (92.3 (14.5) to 117.0 (28.5)%; tied p < 0.02), as did weight for height (W/H; 90 (9.4) to 94 (8.5)%; tied p = 0.043). In the CF control patients the number of infections (2.0 (2.0)), energy intake (116 (43.3)%) and nutritional status remained stable (W/H 99 (17.2)%), but pulmonary function decreased significantly (ΔFEV₁ loss of 2.0 (8.0)%). There was a significantly different evolution for the change in forced vital capacity (p < 0.004) and ΔFEV₁ (p < 0.001) between supplemented and control patients. Conclusions: Analysis of the clinical data on Zn supplementation in CF showed beneficial effects in Zn-deficient CF patients. These results must be confirmed in a prospective double-blind randomized control trial.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Zinc Supplements in Cystic Fibrosis Patients

et al. 2008

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“…In a previous contribution newly diagnosed, untreated CF patients were compared to healthy age-matched controls and no differences of serum Zn concentrations were observed in CF as well at diagnosis, as after one year of CF therapy (9). Since many of the older CF patients still present symptoms also commonly seen in Zn deficiency, a cross-sectional study of the serum Zn concentration of treated CF patients was performed here.…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Concentrations in Cystic Fibrosis Patients Aged Above 4 Years: A Cross-sectional Evaluation

Biervliet

Velde

et al. 2007

Biol Trace Elem Res

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Aim: Assess the risk of zinc (Zn) deficiency in the older cystic fibrosis (CF) population. Method:Cross sectional investigation of all CF patients above the age of 4 followed at the Ghent university centre between 2002 and 2003. Data on age, weight and height z-score, pancreatic and pulmonary functions, chronic pseudomonas infection and CF transmembrane conductance regulator (CFTR) mutations were collected. Serum Zn, vitamin A, E, retinol binding protein (RBP), albumin, sedimentation rate, total IgG and cholesterol were determined. Serum Zn was compared with a local healthy control group (1) and with literature data (3). Results: 101 patients (median age 16 years) were included. There was no difference in serum Zn concentration between CF patients and controls. In CF patients no difference in serum Zn concentration between pancreatic sufficient or insufficient patients was seen. Serum Zn was not associated to nutritional status or height Z-score. A significant association serum Zn to serum albumin (p< 0.0005) and to vitamin A (p< 0.01) was seen. No associations of serum Zn to serum vitamin E, RBP, cholesterol or CFTR were present. There is a significant association serum Zn -forced vital capacity (p<0.01). Serum Zn was not associated to inflammatory parameters or chronic pseudomonas infection. Conclusion: Comparison of CF patients with local controls revealed no significant differences. However, since persisting steatorrhoea increases Zn loss (2) and 12.6% of our population has a serum Zn below the P 2.5 value of the NHANES II study (3), there could remain an increased risk of Zn deficiency in some CF patients. Further on the association with pulmonary function needs more investigation.

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“…It is thought that steatorrhea causes loss of zinc in the stool and should lead to low zinc levels among children with cystic fibrosis. However, no such relation was found in the study on 36 children with cystic fibrosis by Van Biervliet et al 14 Another study reported that serum zinc levels in children with cystic fibrosis were similar to those of normal controls but that children with lower serum zinc levels had significantly worse results on the pulmonary function tests. 15 An increase has been observed in the sputum zinc levels in pulmonary exacerbations, and a decrease has been observed in the levels after treatment in bronchiectasis (cystic fibrosis and non-cystic fibrosis bron- chiectasis); however, the significance of this remains unclear.…”

Section: Discussionmentioning

confidence: 90%

Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection

Sharma¹,

Lodha²,

Shastri³

et al. 2015

Respir Care

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BACKGROUND: Children with cystic fibrosis may have a deficiency of micronutrients, including zinc, which may affect their susceptibility to infections. There is a paucity of data on zinc supplementation among children with cystic fibrosis. We hypothesized that a pharmacologic dose of zinc administered daily for 12 months would reduce the need for antibiotics by 50%. METHODS: This double-blind randomized placebo-controlled trial was conducted among children with cystic fibrosis to assess the effect of zinc supplementation on the need for antibiotics and pulmonary function tests. The children, age 5-15 y, of either sex, received either 30-mg zinc tablets or similar looking placebo tablets daily in addition to standard care. They were followed up every month for a period of 12 months and whenever they had pulmonary exacerbations. Their serum zinc was estimated at baseline and at 12 months of enrollment. During each visit, the children underwent a pulmonary function test and sputum culture. RESULTS: Of a total of 43 children screened, 40 were enrolled, and of them, 37 completed the study. The median (interquartile range) number of days of the administration of antibiotics over 12 months of follow-up among the children receiving zinc was 42 (14 -97) d. In the placebo group, it was 38 (15-70) d (P ‫؍‬ .79). There were no significant differences in the percent-of-predicted FEV 1 or change in FEV 1 values at 12 months (P ‫؍‬ .44). The number of children in whose respiratory specimens Pseudomonas was isolated was similar for the 2 groups at different time intervals. The adverse events reported were similar in the 2 groups. CONCLUSION: We did not find any significant difference in the need for antibiotics, pulmonary function tests, hospitalization, colonization with Pseudomonas, or the need for antibiotics for children with cystic fibrosis receiving zinc supplementation of 30 mg/d.

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Serum Zinc in Patients with Cystic Fibrosis at Diagnosis and After One Year of Therapy

Cited by 16 publications

References 22 publications

The Effect of Zinc Supplements in Cystic Fibrosis Patients

The Effect of Zinc Supplements in Cystic Fibrosis Patients

Serum Zinc Concentrations in Cystic Fibrosis Patients Aged Above 4 Years: A Cross-sectional Evaluation

Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection

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