Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

Öztürk, Nurınnısa; Kurt, Nezahat; Özgeriş, Fatma Betül; Baygutalp, Nurcan Kılıç; Tosun, Mahya Sultan; Bakan, Nuri; Bakan, Ebubekîr

doi:10.5152/eurasianjmed.2015.104

Cited by 23 publications

(30 citation statements)

References 16 publications

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“…in 67 H. pylori seropositive and 94 seronegative children, without finding any significant difference between groups. Two Turkish groups looked at deficiencies of other micronutrients than iron in relation to H. pylori status including reduced holotranscobalamin levels indicating vitamin B12 deficiency and levels of zinc, copper, magnesium, and selenium . However, both studies had major methodical limitations not allowing firm conclusions.…”

Section: Clinical Presentationmentioning

confidence: 99%

Helicobacter pylori in children

2016

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Helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. In high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. Other controversial issues are related to the question of which H. pylori-infected children benefit from treatment and which is the best regimen to eradicate the infection in the presence of a worldwide increasing antibiotic resistance. The first large-scale randomized placebo-controlled vaccination trial in schoolchildren indicates that prevention of the infection may be possible.

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Section: Clinical Presentationmentioning

confidence: 99%

Helicobacter pylori in children

2016

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“…29,30 Growth is an important but complicated issue; hence, the association between growth and H. pylori infection needs further study. Nurinnisa finds out that the serum concentration of zine is dramatically higher in children with H. pylori infection, but the elements of copper and magnesium have no differences between infected and noninfected children, 31 and Anla reports that there are no significant differences in contents of calcium, magnesium, iron, zinc, selenium, and copper between the two groups. 32 Besides, iron deficiency anemia is revealed to be associated with H. pylori infection.…”

Section: Discussionmentioning

confidence: 98%

Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers

Gao

Zhao

Zhang

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Helicobacter pylori (H. pylori), a gram-negative pathogen, has been shown to colonize multiple organs and cause various forms of extra-gastrointestinal diseases. The association of H. pylori infection with vitamin D status in apparently healthy children remained unclear; therefore, we investigated the relationship between vitamin D and H. pylori infection among apparently healthy infants and toddlers. In this large cross-sectional study, the examination data of children were collected from January 2013 to September 2017 in the Center for Children's Health Care. Among these children, 6,896 infants and toddlers were screened for our study. Helicobacter pylori infection and vitamin D status were the main indicators, and micronutrients (zinc, iron, copper, magnesium), and growth parameters (height, weight, and weight for age Z score [WAZ], height for age Z score [HAZ]) were also analyzed in this study. Among the 6,896 infants and toddlers, the detection rate of H. pylori seropositivity was 30.6%. The prevalence of vitamin D deficiency in H. pylori seropositive and seronegative groups was 20.7% and 12.1%, respectively (P < 0.001). The logistic regression analysis suggested children with H. pylori-positive antibody were 2.06 times more likely to be vitamin D deficient compared with children who had negative H. pylori antibody (odds ratio: 2.06; 95% CI: 1.77, 2.38) after controlling for confounding factors. These data suggested that there was a significant association between H. pylori seropositivity and vitamin D deficiency in children aged 6-36 months, which would make a contribution to the treatment and monitoring of vitamin D deficiency and H. pylori infection.

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“…Numerous studies demonstrated that Hp infection was associated with the deficiency of copper, vitamin B 12 , folic acid, and vitamin A, C, and E [25, 26]. These deficiencies originate from the anorexia caused by dyspeptic symptoms and malabsorption secondary to intestinal bacterial infections, which is the resultant of hypo-achlorhydria in the presence of Hp [27]. Gulsen et al found a statistically significant increase in the serum B 12 and folate levels after Hp eradication [28].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection coexisting with intestinal metaplasia is not associated with colorectal neoplasms

Böyük¹,

Ozgur²,

Atalay³

et al. 2019

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IntroductionColorectal cancer is one of the most common cancers and is a major cause of morbidity and mortality in the world and our country. Studies have indicated that there might be a relationship between Helicobacter pylori (Hp) and colorectal neoplasia (CN), although others have not found any relationship.AimTo determine whether there is a potential relationship between Hp and CN in our patients.Material and methodsA total of 314 patients, aged 16–86 years, who underwent gastroscopy and colonoscopy at our department between 2015 and 2017 were evaluated retrospectively. The age, gender, endoscopy results, presence of Hp, complete blood count (CBC), vitamin B12, folic acid, C-reactive protein (CRP), and sedimentation levels of the patients were examined.ResultsCBC, ferritin, vitamin B12, and CRP measurements did not show statistical significance in terms of the presence of Hp (p > 0.05). Folate values of Hp-positive patients were significantly lower than Hp-negative patients (p = 0.007; p < 0.01). No significant relationship was detected between Hp and colon cancer (p > 0.05). Adenomatous polyps were not related to Hp (p > 0.05). Correlation between intestinal metaplasia (IM) and adenomatous polyps was insignificant. There was no statistically significant difference between colon and gastric pathology results.ConclusionsIn our study, no significant relationship was noted between Hp and CN. A few studies have been conducted in our country, and our results are consistent with some of these studies while it is contradictory to others. Large populational multicentre studies are needed in order to identify the relationship between Hp and CN.

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Serum Zinc, Copper, Magnesium and Selenium Levels in Children with Helicobacter Pylori Infection

Cited by 23 publications

References 16 publications

Helicobacter pylori in children

Helicobacter pylori in children

Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers

Helicobacter pylori infection coexisting with intestinal metaplasia is not associated with colorectal neoplasms

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