Helicobacter pylori infection coexisting with intestinal metaplasia is not associated with colorectal neoplasms

Abstract

IntroductionColorectal cancer is one of the most common cancers and is a major cause of morbidity and mortality in the world and our country. Studies have indicated that there might be a relationship between Helicobacter pylori (Hp) and colorectal neoplasia (CN), although others have not found any relationship.AimTo determine whether there is a potential relationship between Hp and CN in our patients.Material and methodsA total of 314 patients, aged 16–86 years, who underwent gastroscopy and colonoscopy at our department between 2015 and 2017 were evaluated retrospectively. The age, gender, endoscopy results, presence of Hp, complete blood count (CBC), vitamin B12, folic acid, C-reactive protein (CRP), and sedimentation levels of the patients were examined.ResultsCBC, ferritin, vitamin B12, and CRP measurements did not show statistical significance in terms of the presence of Hp (p > 0.05). Folate values of Hp-positive patients were significantly lower than Hp-negative patients (p = 0.007; p < 0.01). No significant relationship was detected between Hp and colon cancer (p > 0.05). Adenomatous polyps were not related to Hp (p > 0.05). Correlation between intestinal metaplasia (IM) and adenomatous polyps was insignificant. There was no statistically significant difference between colon and gastric pathology results.ConclusionsIn our study, no significant relationship was noted between Hp and CN. A few studies have been conducted in our country, and our results are consistent with some of these studies while it is contradictory to others. Large populational multicentre studies are needed in order to identify the relationship between Hp and CN.

Association between Helicobacter pylori infection and the risk of colorectal cancer

“…Of these 47 studies, 9 studies were performed in Europe, [ 33 – 41 ] 9 in American, [ 17 , 24 , 45 – 50 ] 29 in Asia. [ 24 , 36 , 42 – 44 , 51 – 60 ] In most studies, the age of participants was above 60, with male accounting for 52%. The characteristics of these studies are summarized in Table 1 .…”

Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas

“…This may occur via various mechanisms. The cholecystokinin type B/gastrin receptor and gastrin are present in human colorectal polyps, and they are activated in the early stages of the adenoma-carcinoma sequence[ 28 , 29 ]. Persistent exposure to H. pylori infection directly induces the atrophic changes of the gastric body mucosa and increases the gastrin secretion.…”

Relationship between gastric intestinal metaplasia and colorectal neoplasms.

“…Colorectal cancers (CRC) are one of the most common cancers worldwide. Colorectal carcinogenesis usually originates from colorectal adenomas that develop from normal mucosa and the adenoma -carcinoma sequence (6,7). This process gives us a chance to early diagnose and intervene before the development of cancer.…”

“…Clarifying the pathogenesis and the risk factors of colorectal cancers is of great importance in the early diagnosis and treatment of this cancer (7). Various previous studies were conducted on this matter after H. pylori infection was accepted as a risk factor for colorectal cancer in the 1990s (9).…”

“…While some studies determined a positive association between H. pylori infection and colorectal cancers (10)(11)(12)(13)(14)(15), there were studies stating that this was controversial as well (16)(17)(18). In addition, studies investigating the association between gastric IM and colorectal adenomas were also conducted (7,13,19). In a recent study, a significant association between gastric IM and colorectal adenoma prevalence was reported (13).…”