Serum Vitamin D, Zinc Levels and the Relationship between them in Children and Adolescents

Şener, Gülsen; Koçer, Zeynep; Bayrak, Tülin; Bayrak, Ahmet; Gümüş, Alper

doi:10.7754/clin.lab.2021.211003

Cited by 4 publications

(4 citation statements)

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“…The significant association between vitamin deficiency and acute cystitis found in our study is consistent with the known roles of these vitamins in immune system function (2). For example, Vitamin D has immunomodulatory properties that influence both innate and adaptive immune systems (3). Vitamin B12 and folic acid are essential for DNA synthesis and repair, cellular division, and amino acid metabolism, which are critical processes for maintaining immune system functions (4,5).…”

Section: Discussionsupporting

confidence: 83%

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Can vitamin B12, folate, and Vitamin D deficiencies be predisposing factors in cases with acute cystitis?

Akkurt

2023

Med Sci Discov

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Objective: This study aimed to investigate the relationship between vitamin D, vitamin B12, and folic acid deficiencies and the incidence of acute cystitis, considering the vital role of these vitamins in immune system function. Material and Methods: A retrospective analysis was conducted on patients diagnosed with cystitis at our hospital between 2020 and 2022, who had their Vitamin D, B12, and folic acid levels assessed. The prevalence of deficiencies was calculated and statistical analyses were performed to evaluate the association between vitamin deficiencies and acute cystitis. Subgroup analyses were conducted to identify vulnerable populations at higher risk of developing cystitis in the context of vitamin deficiency. Results: Vitamin D deficiency was found in 96% of the patients, followed by Vitamin B12 (44%) and folic acid (35%). Logistic regression models revealed a significant association between vitamin deficiency and acute cystitis (p < 0.05 for all three vitamins). Subgroup analyses identified women and older individuals (≥ 60 years) with vitamin deficiencies as more susceptible to cystitis than their counterparts without deficiencies (p < 0.05). Conclusion: Our study suggests a potential association between Vitamin D, B12, and folic acid deficiencies and the incidence of acute cystitis, particularly among vulnerable populations, such as women and older individuals. These findings highlight the importance of considering nutritional factors in preventing and managing acute cystitis and warrant further investigation in larger prospective studies.

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Section: Discussionsupporting

confidence: 83%

“…The immune system plays a crucial role in preventing and resolving these infections (2). Vitamin B12, folate, and Vitamin D are essential nutrients that significantly impact immune system function (3). Recent studies have highlighted the importance of these vitamins in maintaining a healthy immune response (4).…”

Section: Introductionmentioning

confidence: 99%

Can vitamin B12, folate, and Vitamin D deficiencies be predisposing factors in cases with acute cystitis?

Akkurt

2023

Med Sci Discov

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“…In a study conducted with children between the ages of 0 and 12 years to define vitamin D deficiency and insufficiency and to determine the normal range of 25-OH-D levels, severe vitamin D deficiency was defined as a 25-OH-D level lower than 20 ng/mL, vitamin D deficiency as 21–29 ng/mL, and adequate levels as ≥30 ng/mL (with the preferred range being 40–60 ng/mL), while levels higher than 150 ng/mL were considered as indicating vitamin D intoxication [ 18 ]. In another study conducted with children and adolescents on the health of school-age children, rates of 15% for deficiency and 18% for sufficiency were found [ 19 ]. In a study by Çelik et al [ 2 ], severe vitamin D deficiency was determined in laryngomalacia patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of vitamin D levels and biochemical markers in infants diagnosed with laryngomalacia

BİLAL,

ÇINAR,

İPEK

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim The pathology of laryngomalacia is still not clear. The aim of this study was to investigate the relationship between vitamin D levels and laryngomalacia, and to evaluate vitamin D levels according to the classification of laryngomalacia. Materials and methods This retrospective study was conducted in the Kahramanmara ş S ütçü İ mam University Medicine Faculty’s Otorhinolaryngology Clinic between June 2014 and January 2021. Laryngomalacia was classified. Laboratory tests for all patients included calcium (Ca), phosphorus (P), parathormone (PTH), blood urea nitrogen (BUN), creatinine (Cre), alanine transaminase (ALT), and 25-hydroxy vitamin D (25-OH-D). Results Evaluations were performed for 64 infants with laryngomalacia, including 41 male and 23 female infants with a mean age of 4.6 ± 3.0 months, and a control group of 64 healthy infants with a mean age of 4.5 ± 2.8 months. A statistically significant difference was determined between the laryngomalacia group and the control group with respect to 25-OH-D and PTH levels (p < 0.001). When data were examined according to laryngomalacia types, a statistically significant difference was determined between the groups for 25-OH-D, Ca, P, PTH, and ALT values. The 25-OH-D level was statistically significantly lower in the severe laryngomalacia group than in the mild and control groups (p < 0.001). A statistically significant difference was determined between the moderate and severe laryngomalacia groups and the control group regarding PTH levels (p < 0.001). Conclusion Vitamin D deficiency may have a role in the etiology of laryngomalacia, and this view is supported by the finding that there was a decrease in vitamin D levels associated with laryngomalacia classification. In addition, the reduction in PTH levels in infants with laryngomalacia may be explained by the change in Ca metabolism. It would be appropriate for further studies to investigate the response to vitamin D replacement therapy in patients with moderate and severe laryngomalacia.

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“…Особлива увага, прикута до вітаміну D пояснюється двома причинами. По-перше, виявлена надзвичайно висока (до 50 % від загальної популяції) поширеність у населення планети явної або прихованої D-вітамінної недостатності [2]. По-друге, встановлені нові дані щодо впливу вітаміну D на метаболізм і регуляцію багатьох важливих фізіологічних процесів у різні періоди життєдіяльності людського організму.…”

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Стоматологічна Захворюваність У Дітей 2-5 Років Та Взаємозв’язок З Рівнем Маркерів Метаболізму Кісткової Тканини Та Мінерального Обміну

Сухомейло,

Рейзвіх

2024

Grundlagen Der Modernen Wissenschaftlichen Forschung

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Serum Vitamin D, Zinc Levels and the Relationship between them in Children and Adolescents

Cited by 4 publications

References 0 publications

Can vitamin B12, folate, and Vitamin D deficiencies be predisposing factors in cases with acute cystitis?

Can vitamin B12, folate, and Vitamin D deficiencies be predisposing factors in cases with acute cystitis?

Evaluation of vitamin D levels and biochemical markers in infants diagnosed with laryngomalacia

Стоматологічна Захворюваність У Дітей 2-5 Років Та Взаємозв’язок З Рівнем Маркерів Метаболізму Кісткової Тканини Та Мінерального Обміну

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