Can vitamin B12, folate, and Vitamin D deficiencies be predisposing factors in cases with acute cystitis?

Abstract

Objective: This study aimed to investigate the relationship between vitamin D, vitamin B12, and folic acid deficiencies and the incidence of acute cystitis, considering the vital role of these vitamins in immune system function. Material and Methods: A retrospective analysis was conducted on patients diagnosed with cystitis at our hospital between 2020 and 2022, who had their Vitamin D, B12, and folic acid levels assessed. The prevalence of deficiencies was calculated and statistical analyses were performed to evaluate the association between vitamin deficiencies and acute cystitis. Subgroup analyses were conducted to identify vulnerable populations at higher risk of developing cystitis in the context of vitamin deficiency. Results: Vitamin D deficiency was found in 96% of the patients, followed by Vitamin B12 (44%) and folic acid (35%). Logistic regression models revealed a significant association between vitamin deficiency and acute cystitis (p < 0.05 for all three vitamins). Subgroup analyses identified women and older individuals (≥ 60 years) with vitamin deficiencies as more susceptible to cystitis than their counterparts without deficiencies (p < 0.05). Conclusion: Our study suggests a potential association between Vitamin D, B12, and folic acid deficiencies and the incidence of acute cystitis, particularly among vulnerable populations, such as women and older individuals. These findings highlight the importance of considering nutritional factors in preventing and managing acute cystitis and warrant further investigation in larger prospective studies.