Serum vitamin D levels in relation to abdominal obesity: A systematic review and dose–response meta‐analysis of epidemiologic studies

Hajhashemy, Zahra; Shahdadian, Farnaz; Ziaei, Rahele; Saneei, Parvane

doi:10.1111/obr.13134

Cited by 47 publications

(40 citation statements)

References 84 publications

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“…Various underlying mechanisms have been suggested for the association of serum vitamin D with MetS and its components. Firstly, there is an inverse significant relation between blood vitamin D concentration and abdominal obesity 94 . As the vitamin D is a fat‐soluble vitamin, it tends to be stored in adipose tissues; so, its bioavailability and circulating levels are lower in those with abdominal obesity.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose–response meta‐analysis of epidemiologic studies

et al. 2021

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Summary Several epidemiological studies examined the association of serum vitamin D with metabolic syndrome (MetS), but the findings were inconsistent. We conducted a systematic review and dose–response meta‐analysis to quantify the association between blood vitamin D levels and MetS in adults. A systematic search up to December 2020 was conducted in MEDLINE (PubMed), ISI (Web of Science), Scopus, and Google Scholar databases for epidemiological studies that assessed the relation of serum 25‐hydroxyvitamin D (as the exposure) and MetS (as the outcome) in adults. Eligible cross‐sectional studies were restricted to those with representative populations. Finally, 43 studies were included in the analysis (38 cross‐sectional, one nested case–control, and four cohorts studies). Combining 41 effect sizes from 38 cross‐sectional studies included 298,187 general adult population revealed that the highest level of serum vitamin D, compared with the lowest level, was significantly related to a 43% decreased odds of MetS in developed countries (odds ratio [OR]: 0.57; 95% confidence interval [CI]: 0.49–0.65) and 40% in developing countries (OR: 0.60; 95% CI: 0.52–0.70). Linear dose–response analysis (including 222,175 healthy individuals and 39,308 MetS patients) revealed that each 25 nmol/L increase in serum vitamin D level was significantly associated with a 15% decreased odds of MetS (OR: 0.85; 95% CI: 0.80–0.91); however, we found no significant nonlinear association. Meta‐analysis of five prospective studies with 11,019 participants revealed no significant relation (relative risk [RR]: 0.70; 95% CI: 0.37–1.32). This meta‐analysis indicated an inverse association between serum vitamin D concentrations and risk of MetS in general adult populations in cross‐sectional studies in a dose–response manner. However, no significant association was found in a small number of cohorts. More prospective studies are needed to confirm the causality of this relationship.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose–response meta‐analysis of epidemiologic studies

et al. 2021

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“…Our study also found the correlations of WHR with vitamin D status were stronger than the other obesity markers in both sexes. Several studies demonstrated an inverse correlation between vitamin D status and the risk of abdominal obesity, but most of them included adults of all ages and determined abdominal obesity merely by WC [ 33 ]. Few studies had explored the correlation between vitamin D status and WHR.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

Zhao

Qin

et al. 2021

BMC Geriatr

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Backgrounds Vitamin D deficiency and insufficiency in older adults seems to be common, but the prevalence estimates are lacking in West China. Previous studies suggested that low vitamin D status was associated with obesity. However, most of them evaluated obesity based on body mass index (BMI) and there are no studies at present exploring the association between vitamin D status and different obesity markers. The present study aims to investigate the prevalence of low vitamin D status and evaluate the association between the vitamin D status and different obesity markers among older adults in West China. Methods Data was based on the baseline of West China Health and Aging Trends study (WCHAT). All of the participants were older than 60 years old in the present study. Vitamin D status was based on laboratory data, and obesity markers were assessed by bioelectrical impedance analysis (BIA) using the InBody 770 analyzer. Multiple linear regression was performed to find the association between the vitamin D status and various obesity markers. Results The study included 2661 individuals (mean age: 67.7 ± 6.0 years; males: 41 %). The mean vitamin D level was 18.8 ± 6.3 ng/ml (range: 5 to 59 ng/ml); 5.2 % of participants had a sufficient level of vitamin D, 31.8 % had vitamin D insufficiency, and 63.0 % had vitamin D deficiency. Our results showed that vitamin D status was negatively associated with fat mass index (FMI), visceral fat area (VFA), and waist-hip ratio (WHR) in both sexes. Comparing to other obesity markers, WHR had the strongest correlation with vitamin D status in both sexes (β = -6.090, P = 0.046 in males; β = -11.253, P < 0.001 in females). No significant association was found between vitamin D status and BMI in males. Conclusion The prevalence of vitamin D insufficiency and deficiency among older adults in West China was high. Among the older adults in west China, WHR showed stronger association with vitamin D status and was better for the prediction of vitamin D insufficiency or deficiency in both sexes, compared to BMI. Trial registration Chinese Clinical Trial Registry: ChiCTR1800018895.

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“…A meta-analysis showed that vitamin D status has an inverse relationship with BMI in both diabetic and non-diabetic subjects [ 26 ]. Another meta-analysis showed that serum vitamin D level had an inverse association with the risk of abdominal obesity in a dose-response manner [ 27 ]. Vitamin D deficiency has been considered to be associated with obesity and metabolic dysregulation by modulating the expression of genes related to adipogenesis and inflammatory and oxidative stress in mature adipocytes [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Gender-Dependent Characteristics of Serum 1,25-Dihydroxyvitamin D/25-Hydroxyvitamin D Ratio for the Assessment of Bone Metabolism

Fujita-Yamashita¹,

Yamamoto²,

Honda³

et al. 2021

Cureus

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Objectives Vitamin D deficiency, which is common worldwide, increases the risks of falls and fractures and can lead to increased morbidity and mortality. However, the clinical utility and relevance of vitamin D activation remain unknown. The aim of the present study was to clarify the clinical usefulness of serum 1,25-dihydroxyvitamin D (1,25D)/25-hydroxyvitamin D (25D) ratio for assessment of the extent of bone metabolism. Methods We retrospectively screened data for 87 patients whose serum 1,25D and 25D levels were measured. Eight patients who were taking vitamin D preparations were excluded, and data for 79 patients (33 males and 46 females) were analyzed. Since menopausal status can be associated with serum vitamin D level, we divided the patients by gender and divided the female patients into two groups at the age of 50 years. Results The median serum 1,25D/25D ratio was significantly lower in males than in females, with the most considerable difference in all males [4.1 (interquartile range: 2.3-5.8) × 10 −3 ] versus elderly females (aged ≧50 years) [7.9 (3.3-10.1) × 10 −3 ). Main disorders were endocrine (30.6%), inflammatory (18.5%), and bone-related (16.7%) disorders. The ratios of serum 1,25D/25D had significant negative correlations with femoral dual-energy X-ray absorptiometry % young adult mean (DEXA %YAM) ( R= −0.35) and lumbar DEXA %YAM ( R= −0.32). Significant correlations were found between the 1,25D/25D ratio and serum levels of inorganic phosphate (iP), parathyroid hormone, and alkaline phosphatase (ALP). The 1,25D/25D ratio had gender-specific characteristics: the ratio was significantly correlated with age in males ( R= −0.49), while it was significantly correlated with BMI in females ( R= 0.34). Conclusions The results of this study suggested that vitamin D activity is negatively correlated with bone mineral density, being reduced in aged males but enhanced in obese females.

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Serum vitamin D levels in relation to abdominal obesity: A systematic review and dose–response meta‐analysis of epidemiologic studies

Cited by 47 publications

References 84 publications

Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose–response meta‐analysis of epidemiologic studies

Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose–response meta‐analysis of epidemiologic studies

Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study

Gender-Dependent Characteristics of Serum 1,25-Dihydroxyvitamin D/25-Hydroxyvitamin D Ratio for the Assessment of Bone Metabolism

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