Serum Vitamin D Levels and Severity of Childhood Asthma in Costa Rica.

Brehm, John M.; Celedon, JC; Soto-Quirós, Manuel E.; Ávila, Lydiana; Hunninghake, G.M.; Forno, Erick; Laskey, Daniel; Sylvia, Jody S.; Hollis, Bruce W.; Weiss, Scott T.; Litonjua, Augusto A.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2530

Cited by 2 publications

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“…The degree of severity of asthma was inversely associated with lower Vitamin D levels (p<0.001) which is similar to that observed in a cross sectional study of 616 Costa Rican children. 26 Other studies failed to find a significant relation between Vitamin D levels and asthma severity and control in children. 27 The variation in the result amongst different studies may be due to various genetic and environmental factor.…”

Section: Discussionmentioning

confidence: 98%

Impact of serum vitamin D level on severity of asthma in children

Sachdeva¹,

Dutta²,

Joshi³

et al. 2021

Int J Res Med Sci

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Background: Asthma is the most common chronic respiratory disease among children characterized by reversible airway obstruction. Vitamin D plays an important role in many immune and allergic diseases and it may have a role in asthmatic patients, however this association yet remains uncertain. The present study was designed to assess the level of serum Vitamin D in patients with bronchial asthma and it’s correlation with disease severity.Methods: A prospective observational study was performed from April 2019 to February 2020 in the Paediatric OPD of LNMC and JK Hospital Bhopal. All 90 children with physician diagnosed bronchial asthma (mild, moderate and severe) aged 10 to 18 years of both genders who have come in the OPD (total enumeration sampling) during the above mentioned period were enrolled in to the study. The patients were grouped on the basis of Vitamin D sufficiency and Vitamin D levels were correlated with disease severity.Results: The study comprised 54 boys (60%) and 36 girls (40%) with mean age of 15.1±3.96. Out of 90 children enrolled, 46 had good control over asthma and 37 had uncontrolled asthma. As regards asthma control, 25-OH Vitamin D was lowest among patients with uncontrolled asthma.Conclusions: Vitamin D deficiency was highly prevalent in asthmatic patients and there was a direct and a significant relationship between serum Vitamin D levels, severity of asthma, control of asthma, serum IgE levels and blood eosinophils count. Thus, measuring serum levels of Vitamin D followed by supplementation could be considered in the routine assessment of patients with bronchial asthma.

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Section: Discussionmentioning

confidence: 98%

Impact of serum vitamin D level on severity of asthma in children

Sachdeva¹,

Dutta²,

Joshi³

et al. 2021

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…In various studies reduced serum levels of 25VD3 are found in serum of adult and young AD patients and were even partly inversely correlating with the disease status [12][13][14]. Unfortunately it is not clear if this phenomenon is due to reduced dietary vitamin D intakes, reduced UV skin exposure and/or targeted down-regulation of serum vitamin D homeostasis via vitamin D binding proteins [15,16], comparable to fatty acids and retinoids under inflammatory conditions, reviewed in Rühl [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Various studies postulate that due to reduced 25VD3 levels targeted vitamin D supplementation may be an optimal treatment strategy for improving AD conditions [23,24]. Unfortunately, just limited AD-relevant target organs like the skin and the immune system were examined for vitamin D-mediated signaling during allergic sensitization, chronic manifested atopic dermatitis and after vitamin D-supplementation studies [12][13][14]. These lacks of knowledge make it difficult to judge the potential positive and negative impact of vitamin D signaling and supplementation in AD.…”

Section: Introductionmentioning

confidence: 99%

Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients

Rühl

2020

JOJDC

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Vitamin D-mediated signalling is discussed controversial in regard of allergic sensitization and atopic dermatitis (AD). In this study we determined that in AD patients two main target genes of vitamin D-mediated signalling CYP24A1 (vitamin D 24-hydroxylase) and TSLP (thymic stromal lymphopoietin) are strongly upregulated in both affected as well as non-affected skin of AD patients vs healthy volunteers skin. We conclude that this increased local vitamin D-mediated signalling resulting is in a strong local pro-inflammatory and pro-allergic conditions present in the skin of AD patients with an impact on the systemic vitamin D-signalling and systemic allergic sensitization.

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Serum Vitamin D Levels and Severity of Childhood Asthma in Costa Rica.

Cited by 2 publications

References 0 publications

Impact of serum vitamin D level on severity of asthma in children

Impact of serum vitamin D level on severity of asthma in children

Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients

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