Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients

Abstract

Vitamin D-mediated signalling is discussed controversial in regard of allergic sensitization and atopic dermatitis (AD). In this study we determined that in AD patients two main target genes of vitamin D-mediated signalling CYP24A1 (vitamin D 24-hydroxylase) and TSLP (thymic stromal lymphopoietin) are strongly upregulated in both affected as well as non-affected skin of AD patients vs healthy volunteers skin. We conclude that this increased local vitamin D-mediated signalling resulting is in a strong local pro-inflammatory and pro-allergic conditions present in the skin of AD patients with an impact on the systemic vitamin D-signalling and systemic allergic sensitization.