Serum vitamin D level is associated with speed of processing in multiple sclerosis patients

Darwish, Hala; Farran, Natali; Hannoun, Salem; Tadros, Natalie; Yamout, Bassem; Ayoubi, Nabil K. El; Khoury, Samia J.

doi:10.1016/j.jsbmb.2020.105628

Cited by 7 publications

(7 citation statements)

References 60 publications

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“…Recently, Bäcker-Koduah et al reported that lower serum vitamin D levels were associated with an increased number of changes in T2-weighted MRI scans. However, the authors did not correlate low levels of vitamin D with a decline in grey matter, white matter and total brain volumes [18]. In other studies, no association between vitamin D levels and brain volume was observed [19,20].…”

Section: Vitamin D and Msmentioning

confidence: 82%

Correlation between vitamin D and alterations in MRI among patients with multiple sclerosis

Piędel¹,

Rocka²,

Piwek³

et al. 2021

Ann Agric Environ Med.

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Introduction. Multiple sclerosis (MS) is a disease of unknown etiology. Diagnosis of MS is primarily based on detection of myelin damage by magnetic resonance imaging (MRI) and classification of demyelination according to the McDonald Criteria. Cholecalciferol (vitamin D 3) has been shown to affect the onset and progression of MS via its immunomodulating properties. The role of vitamin D in MS pathogenesis and treatment deserves further investigation, as there is sufficient evidence to suggest a correlation between vitamin D blood level and brain MRI lesion load. State of knowledge. Elevated blood vitamin D concentration is linked with demyelination, as determined by T2-weighted and gadolinium-enhanced MRI. Blood vitamin D blood levels are affected by sun exposure, among other factors; however, there is no evident connection between abnormalities in myelination and seasonality. Vitamin D supplementation among MS patients has been associated with a lower probability of new lesions and loss of existing lesion volume, as observed seen in T1-weighted MRI scans (p=0.03). An increase in TGF-beta levels was noted among patients using vitamin D supplementation, which may suggest a mechanism by which cholecalciferol may improve MS prognosis. Patients with clinically isolated syndrome (CIS) exhibited an inverse correlation between vitamin D concentration and risk of new lesions as seen in T2-weighted MRI scans. Moreover, vitamin D intake among these patients lowered the risk of progression to clinically definite multiple sclerosis (CDMS). Daily intake of vitamin D during fingolimod treatment correlated strongly with lower numbers of new lesions. High dose vitamin D supplementation during interferon beta-1a treatment was linked to lower mean percentage of lesions compared with volume pre-treatment seen by T2-weighted MRI. Results. Recent findings advocate for the monitoring of vitamin D blood levels in MS patients. Vitamin D supplementation should be considered in both MS patients and patients with CIS, where other signs of disease may be delayed. Moreover, vitamin D supplementation appears to lower the likelihood of new demyelination changes apparent in MRI examinations.

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Section: Vitamin D and Msmentioning

confidence: 82%

Correlation between vitamin D and alterations in MRI among patients with multiple sclerosis

Piędel¹,

Rocka²,

Piwek³

et al. 2021

Ann Agric Environ Med.

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“…Patients were recruited in Lebanon with a mean disease duration of 6 years. Patients with deficient vitamin D had lower SDMT scores which improved as a function of vitamin D. Brain volume analysis showed significant changes over time only in patients with sufficient vitamin D [ 27 ]. Similarly, they demonstrated slower IPS in patients with vitamin D deficiency [ 27 ]; however, the disease duration and demographic characteristics were very different since we included Caucasian patients at diagnosis before the introduction of DMTs.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with deficient vitamin D had lower SDMT scores which improved as a function of vitamin D. Brain volume analysis showed significant changes over time only in patients with sufficient vitamin D [ 27 ]. Similarly, they demonstrated slower IPS in patients with vitamin D deficiency [ 27 ]; however, the disease duration and demographic characteristics were very different since we included Caucasian patients at diagnosis before the introduction of DMTs. Alhussain et al also explored cognition (using the Cambridge Neuropsychological Test Automated Battery to assess visuospatial and verbal memory, executive and attentive functions, decision making, and social cognition) in 39 Saudi MS patients in relation to vitamin D levels [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, several clinical trials failed to prove vitamin D as an effective add-on DMT [ 24 ], even though an increase in TGF-beta levels was noted among patients under supplementation, supporting the immunomodulatory effects on MS prognosis by promoting T-reg differentiation [ 25 ]. Few studies explored the possible correlation between CI and vitamin D in the MS population [ 27 , 28 , 29 ], and trials on vitamin D supplementation so far have not included cognitive evaluation [ 23 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Serum Vitamin D as a Marker of Impaired Information Processing Speed and Early Disability in Multiple Sclerosis Patients

et al. 2021

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Slowed information processing speed (IPS) is the hallmark and first cognitive domain to be altered in multiple sclerosis (MS) patients. Insufficient serum vitamin D was previously associated with disease development, relapses, and progression, but little is reported on cognition. However, vitamin D and cognitive impairment (CI) in other neurodegenerative diseases have already been linked. We explored the possible correlation between vitamin D and IPS at diagnosis and early disability at last follow-up in 81 MS patients. At diagnosis, we collected vitamin D levels and performed a Symbol Digit Modalities Test (SDMT). Raw scores were adjusted for age, gender, and educational level. Early disability was evaluated with MS severity score (MSSS) and age-related MSSS (ARMSS). A total of 71 patients (86.58%) showed hypovitaminosis D (19.71 ± 8.76 ng/mL) and 18 patients (21.95%) had CI. Patients with CI showed severe hypovitaminosis D (p = 0.004). No patients with sufficient vitamin D levels had CI. We found a positive correlation between vitamin D levels at diagnosis and (1) SDMT raw and z-score that persisted after correction for sunlight exposure and MRI baseline characteristics, and (2) EDSS, MSSS, and ARMSS after a mean 2 year follow-up. Low vitamin D levels may affect both cognition and early disability in newly diagnosed MS patients.

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“…Exercise, healthy diet, and social engagement are all linked to better cognitive performance among pwMS (Strober et al, 2018). Smoking and vitamin D deficiency, which are known risk factors for developing MS and accelerating disease progression, also negatively affect cognition in MS (Darwish et al, 2020;Özcan et al, 2014). The positive lifestyle activities mentioned are all critical recommendations for maximizing brain health.…”

Section: Lifestyle Factorsmentioning

confidence: 99%

Multiple sclerosis.

Chen¹,

Benedict²,

DeLuca³

2023

APA Handbook of Neuropsychology, Volume 1: Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions (Vol.

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Serum vitamin D level is associated with speed of processing in multiple sclerosis patients

Cited by 7 publications

References 60 publications

Correlation between vitamin D and alterations in MRI among patients with multiple sclerosis

Correlation between vitamin D and alterations in MRI among patients with multiple sclerosis

Serum Vitamin D as a Marker of Impaired Information Processing Speed and Early Disability in Multiple Sclerosis Patients

Multiple sclerosis.

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