Serum Vitamin D Level at ICU Admission and Mortality

Atalan, Hakan Korkut; Güçyetmez, Bülent

doi:10.5152/tjar.2017.60234

Cited by 11 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This relationship is commonly found in critically ill people [ 1 – 9 ]. The pleiotropic effects of vitamin D in immunity, endothelial and mucosal functions as well as glucose and calcium homeostasis, may be fundamental to common illnesses encountered by critically ill dogs as they are in humans [ 42 , 43 ]. More specifically, the role of vitamin D as a potent modulator of the immune system may best explain the increased risk of mortality in critically ill dogs and people.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D concentrations in hospitalized critically ill dogs

et al. 2018

View full text Add to dashboard Cite

Hypovitaminosis D has been extensively documented in critically ill humans. However, whether or not critically ill dogs have alterations in vitamin D concentrations remains unconfirmed. The primary aims of our study were to compare serum 25-hydroxycholecalciferol [25(OH)D] concentrations in critically ill dogs with healthy control dogs, determine the prognostic utility of serum 25(OH)D concentration as a biomarker in critically ill dogs, and to assess if serum 25(OH)D concentrations in critically ill dogs are associated with length of stay in the intensive care unit or illness severity. Serum concentrations of 25(OH)D together with a range of other clinical, biochemical, and hematological parameters, were measured in 99 dogs within 24 hours of admission to the Intensive Care Unit (ICU). Critically ill dogs (P = 0.001) and dogs with sepsis (P = 0.002) had significantly lower serum 25(OH)D concentrations compared to healthy control dogs. In addition, serum 25(OH)D concentration was an independent predictor of in-hospital and 30 day survival. Using a cut-off of 33 ng/mL, serum 25(OH)D concentrations had excellent sensitivity (0.94; 95% CI, 0.71–1.00), but poor specificity (0.41; 95% CI, 0.31–0.53) for detection of survival. Serum 25(OH)D concentrations were inversely associated with acute patient physiologic and laboratory evaluation (APPLE) fast score but were not associated with ICU length of stay. Hospitalized dogs with critical illness have decreased serum 25(OH)D concentrations compared to healthy dogs and can be used to predict survival in this cohort.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum vitamin D concentrations in hospitalized critically ill dogs

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Relation between Vit D deficiency and mortality in critically ill patients has been reported previously (10,11). In research investigating a relationship between the Vit D level and ICU mortality in Turkey Vit D level was measured at admission (12)(13)(14). Serially Vit D levels were measured in this study.…”

Section: Introductionmentioning

confidence: 80%

Vitamin D levels in critically ill patients on admission and during the intensive care unit stay and its association with short and long-term morbidity and mortality: A single center observational study

Gündoğan¹

2020

Erciyes Med J

View full text Add to dashboard Cite

Objective: The present study aims to evaluate vitamin D (Vit D) level in critically ill patients and to assess its level about morbidity and mortality. Materials and Methods: This study was conducted in an intensive care unit (ICU). Vit D level was measured on admission, third and seventh day. Results: Of the 62 patients, the median Vit D level at baseline and on the third and seventh days was 12.8 mcg/L, 8.35 mcg/L, and 9.30 mcg/L, respectively. Vitamin D level was low (<30 mcg/L) in 92% of patients at baseline and 97% on the third day. 23% of the studied patients developed a new site infection. No statistically difference in the Vit D level at baseline, or on the third or seventh day based on the presence of infection (p=0.556, p=0.404, p=0.439, respectively). The most commonly seen infections were ventilator-associated pneumonia (VAP) and catheter-related bloodstream infection (CRBSI). The growth of Acinetobacter baumannii was the most frequent. Vit D level (p>0.05) might not have a causal role in mortality (ICU, 30-day, and 6-month), and no correlation was found between them. Conclusion: The level of Vit D was low. Our study did not show any relationship between mortality rates and Vit D level, but VAP and CRBSI were observed.

show abstract

“…Atalan ve arkadaşlarının yoğun bakım girişindeki vitaminin D düzeylerinin mortalite ile ilişkisini değerlendirdikleri bir çalışmada, düşük serum vitamin D düzeylerinin yalnızca APACHE II skorunun artmasıyla ilişkili olabileceğini ve YBÜ girişindeki en kötü klinik durumdan sorumlu olabileceğini belirtmişlerdir. [29] Biz de mortalite-morbidite skoru açısından değerlendirdiğimizde kontrol grubunda GKS ve APACHE II değerleri daha iyi olmasına rağmen her iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı. Sadece T3 zamanında vitamin D ve diğer değişkenlere uygulanan korelasyon testinde APACHE II değerleri, MV gün, T3 albümin, T3 prealbümin ve T3 total proteinle istatistiki olarak anlamlı ilişki bulundu.…”

Section: Discussionunclassified

The effect of vitamin-d levels on prognosis of elderly patients treated in intensive care unit

Özay¹,

Mungan²,

Ercan³

et al. 2020

Journal of Contemporary Medicine

View full text Add to dashboard Cite

Amaç: Dünyada yaşlı nüfusun %50-60'ında vitamin D eksikliği vardır. Kritik hastalarda ise vitamin D eksikliğinin (25 (OH) D<20ng/ ml) prevalansı %70'i aşmaktadır. Bu çalışmada Yoğun Bakım Ünitesi (YBÜ)'nde takip ve tedavi edilen 65 yaş üstü; vitamin D verilen ve verilmeyen hastaların prognoz açısından karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Kasım 2014-Nisan 2015 tarihleri arası hastanemiz YBÜ 'de takip ve tedavi edilen hastaların kayıtları geriye dönük olarak incelendi. Enteral beslenen ve vitamin D desteği alan 20 hasta (Grup D), enteral beslenen ancak vitamin D desteği almayan 20 hasta (Grup K) arasında yoğun bakıma kabul sırasında (T1), 7. (T2) ve 15. (T3) günlerde ölçülen vitamin D, albümin, prealbumin, total lenfosit, CRP düzeyleri ve triceps kas kalınlığı açısından fark olup olmadığı değerlendirildi. Bulgular: İki grup demografik veriler açısından benzerdi. Grup D ile Grup K arasında T1,T2 ve T3 zamanlarında vitamin D düzeyleri, albüminprealbümin düzeyleri, enfeksiyon oranları, mekanik ventilasyon süreleri, yoğun bakım yatış günü ve mortalite açısından istatistiksel olarak anlamlı bir fark saptanmazken T1 ve T2 zamanında total lenfosit (TLS) düzeyleri (p<0,05) vitamin D grubunda istatistiksel olarak anlamlı yüksek idi. Hastaların sadece T3 zamanında vitamin D ve diğer değişkenler ele alındığında ise APACHE II değerleri, MV gün, T3 albümin, T3 prealbümin ve T3 total proteinle istatistiki olarak anlamlı ilişki gözlendi. Sonuç: Çalışmamızda vitamin D verilen grupla verilmeyen grup arasında bazı değişkenlerde anlamlı fark gözlenmesi, prospektif ve daha fazla sayıda hasta ile yapılacak çalışmalar açısından yol gösterici olacağını düşünmekteyiz.

show abstract

Serum Vitamin D Level at ICU Admission and Mortality

Cited by 11 publications

References 30 publications

Serum vitamin D concentrations in hospitalized critically ill dogs

Serum vitamin D concentrations in hospitalized critically ill dogs

Vitamin D levels in critically ill patients on admission and during the intensive care unit stay and its association with short and long-term morbidity and mortality: A single center observational study

The effect of vitamin-d levels on prognosis of elderly patients treated in intensive care unit

Contact Info

Product

Resources

About