Serum vitamin d inversely correlates with depression scores in people with multiple sclerosis

El‐Salem, Khalid; Khalil, Hanan; Al‐Sharman, Alham; Al-Mistarehi, Abdel-Hameed; Yassin, Ahmed; Al-Hayk, Kefah; Qawasmeh, Majdi Al; Bashayreh, Salma Y.; Kofahi, Raid; Obeidat, Ahmed Z.

doi:10.1016/j.msard.2020.102732

Cited by 13 publications

(13 citation statements)

References 48 publications

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“…Of the 37 studies that were screened for eligibility, only 11 were considered eligible and included. Among them, nine were full text articles, two were abstracts, seven were cross-sectional studies [ 26 , 43 , 44 , 45 , 46 , 47 , 48 ] one was a retrospective cohort study [ 49 ] and two were prospective longitudinal studies [ 50 , 51 ]. Only one study was a RCT [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similar results were reported by the studies of Knippenber et al [ 48 ] and Silva et al [ 45 ]. El Salem 2021 et al [ 26 ] found a significant correlation between serum vitamin D level and scores of depression scales in males but not in females. Other studies [ 44 , 46 ] did not find a significant association between vitamin D levels and depression.…”

Section: Resultsmentioning

confidence: 99%

“…They did not find any significant association between low vitamin D levels and depression. El Salem 2021 et al [ 26 ] observed a significant correlation between serum vitamin D levels and scores of depression scales in males but not in females. Taylor 2014 et al [ 47 ] studied the association between modifiable lifestyle factors and risk of depression in MS patients.…”

Section: Resultsmentioning

confidence: 99%

“…To our knowledge, this is the first review that has investigated the relationship between vitamin D and depressive symptoms in pwMS. Among the studies correlating vitamin D serum level with depressive symptoms, Ashtari et al [ 43 ], Knippenberg et al [ 48 ], Silva et al [ 45 ], and El Salem 2021 et al [ 26 ], found that low serum circulating levels of vitamin D were inversely associated with depression scale scores. The reported effect sizes ranged between small and medium values.…”

Section: Discussionmentioning

confidence: 99%

“…Among the CAM, attention has been given to vitamin D, a lipid-soluble vitamin mostly produced from exposure of the skin to sunlight; it is also acquired via dietary intake. The metabolite of vitamin D that is abundant in the circulation is 25-hydroxyvitamin D (25(OH)D); it is also considered to better describe vitamin D status [ 26 ].Vitamin D deficiency is currently considered to be one of the environmental risk factors for the pathogenesis and progression of MS [ 27 ]. Vitamin D presents an immune-modulatory effect able to induce an increase in anti-inflammatory cytokines and a decrease in pro-inflammatory cytokines [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

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et al. 2021

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Background. Vitamin D deficiency has been correlated with Multiple Sclerosis (MS) risk and disease activity. There is some controversy as to whether vitamin D could have an impact on depressive symptoms in people with MS (pwMS). The aim of this scoping review was to evaluate the association between vitamin D status and depressive symptoms in pwMS. Methods. We searched databases to include studies published up to March 2021 to provide an overview of the available evidence on the correlation between vitamin D status and depressive symptoms in pwMS. The eligibility criteria were as follows: studies evaluating the use of vitamin D measurement on depressive symptoms in patients suffering from MS, including randomized and non-randomized studies; studies written in English; and studies exploring an adult population over the age of 18. Results. Eleven studies met our inclusion criteria: two of them were abstracts only; the majority were cross-sectional studies; two were prospective longitudinal studies; one was a retrospective cohort study; and one was a randomized placebo-controlled trial (RCT). Of the eleven studies selected, seven showed a potential correlation between low vitamin D levels and depressive symptoms. Conclusion. Future RCT studies should include patients with greater severity of depressive symptoms and should consider confounding factors such as sun exposure and seasonal variation of vitamin D.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Concerto

Rodolico

Ciancio

et al. 2021

IJERPH

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SARS-CoV-2 infection in multiple sclerosis patients: interaction with treatments, adjuvant therapies, and vaccines against COVID-19

et al. 2022

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The SARS-CoV-2 pandemic has raised particular concern for people with Multiple Sclerosis, as these people are believed to be at increased risk of infection, especially those being treated with disease-modifying therapies. Therefore, the objective of this review was to describe how COVID-19 affects people who suffer from Multiple Sclerosis, evaluating the risk they have of suffering an infection by this virus, according to the therapy to which they are subjected as well as the immune response of these patients both to infection and vaccines and the neurological consequences that the virus can have in the long term. The results regarding the increased risk of infection due to treatment are contradictory. B-cell depletion therapies may cause patients to have a lower probability of generating a detectable neutralizing antibody titer. However, more studies are needed to help understand how this virus works, paying special attention to long COVID and the neurological symptoms that it causes.

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Depression and anxiety in multiple sclerosis. Review of a fatal combination

Jellinger

2024

J Neural Transm

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Serum vitamin d inversely correlates with depression scores in people with multiple sclerosis

Cited by 13 publications

References 48 publications

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

SARS-CoV-2 infection in multiple sclerosis patients: interaction with treatments, adjuvant therapies, and vaccines against COVID-19

Depression and anxiety in multiple sclerosis. Review of a fatal combination

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