Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Concerto, Carmen; Rodolico, Alessandro; Ciancio, Adriana; Messina, Christian; Natale, Antimo; Mineo, Ludovico; Battaglia, Fortunato; Aguglia, Eugenio

doi:10.3390/ijerph19010199

Cited by 5 publications

(3 citation statements)

References 67 publications

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“…Some limitations were also shown, i.e., a small number of included studies and publication bias. Researchers have shown that vitamin D supplementation supports the treatment of MS patients and reduces the appearance of depression symptoms [58][59][60][61], although studies on this issue are contradictory and inconclusive [62]. Future research on vitamin D and MS depression symptoms should include patients with actual depression symptoms at baseline and include confounders such as exposure to the sun.…”

Section: Vitamins Vitamin Dmentioning

confidence: 99%

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

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Purpose: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system in which multifocal damage to the brain and spinal cord occurs. The etiology of MS remains unclear but it is often recognized by researchers as a multifactorial disease that involves autoimmune and genetic predisposition combined with environmental influences (e.g., low vitamin D levels, smoking, obesity). An adequate and balanced diet can be extremely helpful in improving the condition of MS patients, effectively supporting pharmacological therapy. The purpose of the study was to investigate whether, and if so, to what extent, the intake of macronutrients, vitamins, and microelements may affect the course of MS. Views: The review presents data from studies published between 2017 and 2022. Conclusions: There are numerous studies on the role of specific dietary components in the treatment of MS, but the results are still limited. More work is needed to define the tools required for the assessment of patients' eating habits because dietary factors can affect the functioning and quality of life of MS patients and should therefore be evaluated to assist in comprehensive treatment and recovery.

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Section: Vitamins Vitamin Dmentioning

confidence: 99%

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

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“…Various factors such as sleep disturbances, endocrine dysfunction, and mood disorders can contribute to the development or exacerbation of fatigue, necessitating careful investigation for the potential underlying causes [ 45 ]. The association with anxiety and depression could be explained by the underlying pathogenic mechanisms such as alteration of HPA [ 46 ] and noradrenergic pathways as well as the involvement of pro-inflammatory cytokines [ 30 , 47 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

Ciancio

Moretti

Natale

et al. 2023

JCM

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(1) Background: Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease. Fatigue is a prevalent and debilitating symptom that significantly impacts the quality of life of these patients. A relationship between personality traits and fatigue in MS has been hypothesized but not clearly defined. (2) Methods: A literature search was carried out from databases up to April 2023 for studies correlating personality traits and fatigue in patients suffering from MS. (3) Results: A total of ten articles was included; most of the studies depict a neuroticism–fatigue correlation; however, they were not consistent in terms of the fatigue, personality, and covariate assessments. (4) Conclusions: The clinical and methodological heterogeneity of the included studies prevented us from drawing any firm conclusion on the link between personality traits and fatigue in MS. Several models of personality and different fatigue assessments have been found. Despite this, a common pathway shows that the neuroticism trait or similar personality patterns has a role in fatigue diagnosis. This may be a useful target to improve the quality of life and enhance the modification of the disease treatment results. Further homogeneous and longitudinal studies are needed.

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“…Intrathecal inflammation in people with MS (PwMS) and depression leads to increased neurodegeneration and thus progression of disability [2]. However, depression can also indicate inflammatory reactivation in MS [3].…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature

Goischke

2023

Explor Neurosci

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Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseases are characterized by an imbalance of proinflammatory and antiinflammatory cytokines, increased serum neurofilament light chains (sNfLs), disruption of the blood-brain barrier (BBB), abolition of the physiological function of the various types of microglia (MG), decreased calcidiol-serum levels, and disorders of the gut microbiome in combination with hyperactivity of the hypothalamic-pituitary-adrenal (HPA)-axis/microbiome-gut-brain-axis characterized. In depression, stress initiates cellular and molecular changes in the brain via increased cortisol release in the HPA-axis. Microglial activation and neuronal damage as well as dysregulation of neuroplastic and neurotrophic factors complete the spectrum of pathological damage. It is shown that gut dysbiosis leads to increased gut permeability, which favors endotoxemia and ultimately paves the way to systemic inflammation. A VitD supplementation could restore the balance of microorganisms in the intestine and reduce the inflammatory processes at various levels. VitD promotes regulatory T cell (Treg) proliferation, inhibits the expression of T helper 1 (Th1) cells and Th17 immune cells, and inhibits proinflammatory interleukin-17 (IL-17). 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] reduces also the secretion of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). Increased calcitriol levels lead to a reduction in MG activation, oxidative stress, and lower BBB permeability. An early, permanent, daily sufficient VitD supplementation as an add-on therapy under control of the serum 25-hydroxyvitamin D [s25(OH)D] levels is an essential therapeutic tool to slow down the disability caused by MS and thereby primarily prevent or reduce the stress and subsequently the manifestation of depression. Through the future continuous measurement of the biomarkers serum neurofilament ligth chains and glial fibrillary acidic proteins as well as the s25(OH)D level in MS and comorbidity depression, future therapy successes or failures can be avoided.

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Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Cited by 5 publications

References 67 publications

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature

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