Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes

Knekt, Paul; Laaksonen, Maarit A.; Mattila, Catharina; Härkänen, Tommi; Marniemi, Jukka; Heliövaara, Markku; Rissanen, Harri; Montonen, Jukka; Reunanen, Antti

doi:10.1097/ede.0b013e318176b8ad

Cited by 289 publications

(243 citation statements)

References 28 publications

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“…15 Recently, Anoop Shankar et al 16 studied the relationship between serum 25-hydroxyvitamin D levels and prediabetes in an American population, using data from NHANES III. The group with prediabetes comprised 42.9% females versus 55.6% in the non-prediabetes group.…”

Section: Discussionmentioning

confidence: 99%

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

et al. 2014

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CONTEXT AND OBJECTIVE: Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes. DESIGN AND SETTING: Cross-sectional study at a tertiary hospital. METHODS: Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m 2 ; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic). RESULTS: There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m 2 ). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl). CONCLUSION: There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed.RESUMO CONTEXTO E OBJETIVO: Vários estudos já avaliaram o papel da 25-hidroxivitamina D (25OHD3) na patogênese do diabetes tipo 2 (DM2) e apresentaram resultados controversos. Os processos metabólicos que culminam no DM2 se iniciam no pré-diabetes. Nosso objetivo foi analisar a associação da 25OHD3 com o metabolismo glicêmico em indivíduos sem diagnóstico mas com alto risco para diabetes. TIPO DE ESTUDO E LOCAL: Estudo transversal em hospital terciário. MÉTODOS:Medidas antropométricas e laboratoriais foram determinadas em pacientes com um ou mais dos fatores de risco: hipertensão; índice de massa corpórea (IMC) ≥ 25 kg/m 2 ; circunferência abdominal > 80 cm no sexo feminino e > 94 cm no sexo masculino; parentes de primeiro grau com diabetes; mulheres com filho nascido grande para idade gestacional ou com DM2 na gravidez; colesterol HDL (high density lipoprotein) < 35 mg/dl e triglicerídeo > 250 mg/dl. Os pacientes foram divididos em dois grupos: um com pré-diabetes (glicemia de jejum ou teste de tolerância oral à glicose alterados) e outro com glicose normal (euglicêmicos). RESULTADOS: Entre pré-diabéticos (n = 38) e euglicêmicos (n = 15) não houve diferença estatística na idade (66,4 ± 10,6 versus 62,6 ± 9,1 anos), gênero (52,6 versus 73,3% feminino) e IMC (30,1 ± 4,61 versus 27,9 ± 4,7 kg/m 2 ). Baixos niveis séricos de 25OHD3 foram encontrados nos dois grupos, sem diferença estatística entre eles (29,1 ± 11,8 versu...

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Section: Discussionmentioning

confidence: 99%

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

et al. 2014

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“…The level of education was classified into three categories based on the years of education. Venous blood samples were taken, and the sera were kept frozen at -20°C until 2003, when the serum 25-hydroxyvitamin D concentrations were determined using the radioimmunoassay (RIA, DiaSorin, MI) [22].…”

Section: Measurements and Definition Of Determinantsmentioning

confidence: 99%

Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up

et al. 2011

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Introduction Vertebral fractures predict mortality, but little is known about their associations with the causes of death. We studied vertebral fractures for prediction of cause-specific mortality. Material and methods A nationally representative sample of 3,210 men and 3,730 women participated Mini-Finland health survey in [1978][1979][1980]. Vertebral fractures at the Th1-Th12 levels were identified from chest radiographs at baseline. Cox's proportional hazard model was used to estimate the strength of association between vertebral fracture and mortality. Results The relative risk (95% confidence interval) of death from natural causes was 1.49 (0.89-2.48) in men and 0.89 (0.60-1.31) in women with vertebral fractures (adjusted for age, body mass index, serum 25-hydroxyvitamin D, educational level, smoking, alcohol intake, physical activity and self-rated general health). Among women the adjusted relative risk of an injury death was 8. 51 (3.48-20.77), whereas none of the men with vertebral fracture died due to an injury. Conclusion The patterns of mortality predicted by fracture in the thoracic spine differ between men and women.

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“…However, some studies assessed only dietary vitamin D intake [6,7], which does not include the major non-dietary component of vitamin D from sun exposure. Other studies measured circulating 25 (OH)D, the best indicator of vitamin D status [8], but had small sample sizes or a limited number of cases [9][10][11]. A recent study reported no association between 25(OH)D and risk of diabetes among older women [12].…”

Section: Introductionmentioning

confidence: 99%

Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies

et al. 2012

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Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes

Abstract: The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association.

Cited by 289 publications

References 28 publications

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up

Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies

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