No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

Giorelli, Guilherme de Vieira; Matos, Lívia Nascimento de; Saado, Amir; Soibelman, Vera Lúcia; Dias, Cristiane Bitencourt

doi:10.1590/1516-3180.2013.7180005

Cited by 11 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Already at the early stages of the disease, there were initial metabolic deregulations, evidenced by alterations in glucose tolerance during the GTT and ITT, as well as the glucose and insulin levels, indicative of insulin resistance, in agreement with other studies [18,26,27]. At this stage, although fasting glucose levels are maintained within normal values (normoglycemia), due to compensatory hyperinsulinemia, there is already some degree of glucose intolerance and peripheral insulin resistance, in agreement with other reports [18,28,29,30].…”

Section: Discussionsupporting

confidence: 91%

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet

et al. 2017

View full text Add to dashboard Cite

Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (n = 10)—received 35% of sucrose in drinking water; Control (n = 12)—received vehicle (water). Body weight, food, and beverage consumption were monitored and glucose, insulin, and lipid profiles were measured. Serum and liver triglyceride concentrations, as well as the expression of genes and proteins involved in lipid biosynthesis were assessed. The insulin-stimulated glucose uptake and isoproterenol-stimulated lipolysis were also measured in freshly isolated adipocytes. Even in the absence of obesity, this rat model already presented the main features of prediabetes, with fasting normoglycemia but reduced glucose tolerance, postprandial hyperglycemia, compensatory hyperinsulinemia, as well as decreased insulin sensitivity (resistance) and hypertriglyceridemia. In addition, impaired hepatic function, including altered gluconeogenic and lipogenic pathways, as well as increased expression of acetyl-coenzyme A carboxylase 1 and fatty acid synthase in the liver, were observed, suggesting that liver glucose and lipid dysmetabolism may play a major role at this stage of the disease.

show abstract

Section: Discussionsupporting

confidence: 91%

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The authors found no association between vitamin D deficiency and HbA1c levels 7 . In a smaller crosssectional study of Brazilian patients, Giorelli et al 8 found no association between vitamin D levels and the risk of prediabetes. The present findings are in accordance with those of Modi et al 7 and Giorelli et al 8 There are potential explanations for the discrepancies in the present study results, including the size of the effect.…”

Section: Discussionmentioning

confidence: 91%

“…There is a growing debate over the association between low 25hydroxyvitamin D (vitamin D) levels and the risk of diabetes mellitus/prediabetes development 1,2 . A large number of crosssectional studies [3][4][5] , but not all of them [6][7][8] , have shown an inverse association between vitamin D status and impaired glucose tolerance, insulin resistance or diabetes mellitus 9 . Reported data also suggest an association between low vitamin D levels with poor diabetes mellitus control 10,11 and diabetes mellitus related complications 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Although the relationship between vitamin D and insulin resistance is, relatively, better investigated in patients with diabetes mellitus, data from individuals with prediabetes are limited 3,4,7,8 . Some observational data have suggested that vitamin D levels are negatively correlated with the risk of prediabetes, and with hemoglobin A1c (HbA1c) levels in individuals with prediabetes 3,4 , particularly in obese individuals 15 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes. Materials and Methods We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University’s non‐communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed. Results In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants’ weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index. Conclusions Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels’ effect on the risk of prediabetes might be small compared with other well‐established risk factors, such as obesity.

show abstract

“…The inclusion of vitamin D blood dosage level in the habitual prenatal care could be an interesting action as rickets prophylaxis in newborns and for preeclampsia. We believe, that though this study was the first step, new aspects should be evaluated and addressed in the near future [27][28][29][30][31][32]. But now our results show that low blood levels of vitamin D in the first trimester are associated with pre-eclampsia, but not with birth weight.…”

Section: Discussionmentioning

confidence: 88%

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Ba¹,

Cac²,

Hsr³

et al. 2020

Asp Biomed Clin Case Rep

View full text Add to dashboard Cite

Objective: The present study aimed to evaluate the vitamin D blood dosage during the three gestational trimesters, while identifying the frequency of pregnant women in the normal range, the variance in the three periods and evaluate the association between vitamin D and the obstetric complications such as preeclampsia, diabetes, and weight of the newborn. Methods: This is a longitudinal study with pregnant and non-pregnant women, from which there was collected data of anamneses, physical exam, obstetric info, as well as milk consumption habits, sunscreen and sun exposure, and also the vitamin D blood dosage. Results: There were 91 Pregnant Women studied, from whom the comparison between the vitamin D dosages identified the absence of gestation as a protective factor for VDD; the tendency for lower levels of supplementations when the workplace is in an external environment; the association between vitamin D and pre-eclampsia in the first trimester. Conclusion: The most relevant consequences from VDD were pre-eclampsia in the first trimester, the absence of gestation as a protective factor for VDD, and the need to consider the workplace before supplementation.

show abstract

No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

Cited by 11 publications

References 28 publications

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Contact Info

Product

Resources

About