Serum vitamin B12, folate, ferritin, and iron levels in turkish patients with alopecia areata

Gönül, Müzeyyen; Çakmak, Seray Külcü; Soylu, Seçil; Kılıç, Arzu; Gül, Ülker

doi:10.4103/0378-6323.55430

Cited by 21 publications

(25 citation statements)

References 4 publications

(6 reference statements)

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“…Our data also showed that in AGA patients iron reservoirs were slightly diminished as evidenced by elevated TIBC. Our data in parallel with others' reports indicated that such a hidden iron deficiency could threaten normal hair growth and maintenance and lead to accelerated hair loss and baldness [18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 77%

“…iron deficiency leads to certain kinds of hair loss e.g. female pattern hair loss, telogen effluvium, alopecia areata, alopecia universal [12][13][14][15][16][17], however some researchers denied such claims [18][19][20][21][22]. Clinically iron deficiency is defined either as an increase in total iron binding capacity tion of ferritin under 40 ng/mL [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Dayer

Dehghani

Daer³

et al. 2017

Zahedan J Res Med Sci

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Background: Androgenetic alopecia is the main cause of hair loss and common baldness that affects psychological more than physiological aspects of people's lives. Studies have shown that this multi factorial disorder is initiated by androgens secretion in pubertal period, minerals limitations, autoimmunity, mental stress, genetic predisposition and some alterations in hematological factors. Objectives: The aim of this study was to evaluate the involvement of hematologic parameters in this disease using a case control study design. Methods: In this case-controlled study, two groups each of 80 individuals with androgenetic alopecia were voluntarily included in the study based on their medical histories and clinical examinations and subjected to blood tests for routine hematological parameters. The results were then compared and analyzed using SPSS version 16.0.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Dayer

Dehghani

Daer³

et al. 2017

Zahedan J Res Med Sci

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“…In addition to the studies in the Trost review [67], we identified five additional studies [57, 58, 72–74] examining iron status in patients with AA specifically. Only two of the eight total investigations (Table 4) [57, 58, 68, 70–74] supported an association between iron deficiency and AA.…”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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“…Similar inferences were drawn in other studies. [6][7][8] However there are studies which concluded that low serum ferritn/iron deficiency is strongly associated with hair loss. [1][2][3][4] The relationship between nonscarring scalp alopecia in women and iron deficiency continues to be a subject of debate, 10,11 and the differences in various studies may be due to different study designs, absence of randomized controlled protocols, studies with smaller number of patients, etc.…”

Section: Discussionmentioning

confidence: 99%

Role of Iron Deficiency in Chronic Diffuse Hair Loss

Shrivastava¹,

Sidhar²

2018

RAPL

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There are conflicting reports of association between iron deficiency and hair loss in the literature. So we conducted this study to evaluate the role of iron deficiency in chronic diffuse hair loss in women of reproductive age group. Serum ferritin, a marker of iron deficiency, was recorded in 150 consecutive patients of chronic diffuse hair loss (FPHL n=69, CTE n=81) and in healthy controls (n=100). The mean serum ferritin (SF) recorded was 9.87, 10.80, 10.30 and 11.20 ng/mL for FPHL, CTE, total patients (FPHL and CTE) and control group respectively, and it did not show any significant difference between these groups. Number of patients who recorded a serum ferritin label of less than 10 ng/mL (normal range 10-126ng/mL) were 48 (69.51%), 51 (62%), 99 (66%) and 63 (63%) for FPHL, CTE, total patients and controls respectively, and this also did not reveal any significant difference between the groups. We did not find any association between low serum ferritin (iron deficiency) and chronic diffuse hair loss in women of reproductive age group.

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Serum vitamin B12, folate, ferritin, and iron levels in turkish patients with alopecia areata

Cited by 21 publications

References 4 publications

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

The Role of Micronutrients in Alopecia Areata: A Review

Role of Iron Deficiency in Chronic Diffuse Hair Loss

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