Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis

Koçer, Bilge; Engür, Selin; Ak, Fikri; Yilmaz, Mehtap

doi:10.1016/j.jocn.2008.05.015

Cited by 56 publications

(43 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge there are no studies on the overall prevalence of anemia in MS although some papers indicate a high rate (39%) of iron deficiency anemia [15]. Other studies, which were aimed at analyzing the association between anemia and symptoms such as fatigue and restless leg syndrome, have reported similar rates of anemia (18-30%) in small groups of MS patients [5,18,19]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Anemia and Multiple Sclerosis

et al. 2015

View full text Add to dashboard Cite

Background/Aims: The relationship between multiple sclerosis (MS) and anemia has not been clarified sufficiently. In this retrospective, cross-sectional, case-control study we evaluated in MS patients: (1) prevalence of anemia relative to sex- and age-matched controls; (2) relationships between patients' demographic, clinical and drug-related characteristics and anemia; (3) effect of anemia on the risk of developing MS. Methods: 187 consecutive MS patients (51 males, mean age (±SD) 44.5 ± 10.7 years) and 200 controls (56 males, mean age 45.5 ± 12 years) were included in the study. Anemia was defined as hemoglobin <12 g/dl for females and <13 g/dl for males. Results: There was a significant difference in the prevalence of anemia between MS patients and controls (35 (18.7%) and 19 (9.5%), respectively, p = 0.009). We did not find any association between patients' characteristics and anemia. The occurrence of anemia increased more than twice the risk of developing MS (odds ratio: 2.19, 95% confidence interval 1.19-4.0). Conclusion: Our study showed a consistent association between anemia and MS.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Among the various conditions suspected to be associated with MS, vitamin B12 deficiency and pernicious anemia have been extensively studied, confirming essentially their comorbidity [2,3,4,5]. Several case reports regarding drug-related hemolytic anemia in MS patients have also been described in the literature [6,7,8,9,10,11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Association between Anemia and Multiple Sclerosis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Interestingly, changes in concentrations of methionine, homocysteine, and vitamin B 12 have been reported in sera and plasma in subsets of MS patients (Reynolds et al, 1992;Kocer et al, 2009;Zhu et al, 2011;Gardner et al, 2013), but changes in CNS tissue have not been investigated. In the current study, we investigated the relationship between changes in methionine cycle metabolites, histone H3 methylation, and mitochondria in gray matter from MS and control postmortem cortical tissue samples and in human SH-SY5Y neuroblastoma cells.…”

Section: Introductionmentioning

confidence: 99%

Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis

Singhal¹,

Arning

et al. 2015

J. Neurosci.

View full text Add to dashboard Cite

Mitochondrial changes, including decreased expression of electron transport chain subunit genes and impaired energetic, have been reported in multiple sclerosis (MS), but the mechanisms involved in these changes are not clear. To determine whether epigenetic mechanisms are involved, we measured the concentrations of methionine metabolites by liquid chromatography tandem mass spectrometry, histone H3 methylation patterns, and markers of mitochondrial respiration in gray matter from postmortem MS and control cortical samples. We found decreases in respiratory markers as well as decreased concentrations of the methionine metabolites S-adenosylmethionine, betaine, and cystathionine in MS gray matter. We also found expression of the enzyme betaine homocysteine methyltransferase in cortical neurons. This enzyme catalyzes the remethylation of homocysteine to methionine, with betaine as the methyl donor, and has previously been thought to be restricted to liver and kidney in the adult human. Decreases in the concentration of the methyl donor betaine were correlated with decreases in histone H3 trimethylation (H3K4me3) in NeuNϩ neuronal nuclei in MS cortex compared with controls. Mechanistic studies demonstrated that H3K4me3 levels and mitochondrial respiration were reduced in SH-SY5Y cells after exposure to the nitric oxide donor sodium nitroprusside, and betaine was able to rescue H3K4me3 levels and respiratory capacity in these cells. Chromatin immunoprecipitation experiments showed that betaine regulates metabolic genes in human SH-SY5Y neuroblastoma cells. These data suggest that changes to methionine metabolism may be mechanistically linked to changes in neuronal energetics in MS cortex.

show abstract

“…In 35 MS patients during an acute attack, lower levels of serum vitamin B12 were noted compared to 30 healthy controls [60]. Likewise, in 75 patients with RRMS, serum B12 levels were significantly lower compared to 75 healthy controls [61].…”

Section: Vitamin B12 Deficiencymentioning

confidence: 88%

Is there a Link between Vitamin B and Multiple Sclerosis?

Nemazannikova

Mikkelsen

Stojanovska

et al. 2018

View full text Add to dashboard Cite

Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiency results in severe myelin degeneration that leads to loss in neuronal signal transmission. Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has triggered an increased attention for its role in the methylation process, involvement in myelination and remyelination and reversal of MS symptoms. Here we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in MS. The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising, although with limited clinical studies. Hence, there is an urgent need for larger scope studies to determine the role of vitamin B supplementation alone, or in combination with other therapeutic agents, in prevention or reversal of MS and aid in improved quality of life of MS patients.

show abstract

Serum vitamin B12, folate, and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis

Cited by 56 publications

References 25 publications

Association between Anemia and Multiple Sclerosis

Association between Anemia and Multiple Sclerosis

Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis

Is there a Link between Vitamin B and Multiple Sclerosis?

Contact Info

Product

Resources

About