Serum Vitamin B12 and Folate Concentrations and the Effect of the Mediterranean Diet on Vulnerable Populations

Balcı, Yasemin Işık; Ergin, Ahmet; Karabulut, Aysun Bay; Polat, Azız; Doğan, Mustafa; Küçüktaşçi, Kazım

doi:10.3109/08880018.2013.829894

Cited by 30 publications

(23 citation statements)

References 22 publications

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“…An additional striking finding was the pooled insufficiency rate of 65% (I 2 = 95%) ( Figure 4) (28,52,65,77,93) from the 5 studies in the Eastern Mediterranean region. On the contrary, insufficiency rates of ,8% were found in 2 studies conducted in Thailand and Sudan, where the authors attributed the low rates of insufficiency to the consumption of fish and animal/fermented products, respectively (although details of dietary intake were not provided) (49,50).…”

Section: Prevalence Of Vitamin B-12 Insufficiency In Pregnancymentioning

confidence: 97%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

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Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these populations, the relation between vitamin B-12 and birth weight (BW) elsewhere is unknown. Objectives: We performed a systematic review to assess 1) the worldwide prevalence of vitamin B-12 insufficiency in pregnancy and 2) its association with BW. Design: A search of 5 electronic databases was performed to identify eligible articles. Random-effects meta-analysis was conducted according to geographic regions and pregnancy trimesters for the prevalence subreview and by categorical measures of BW. Results: A total of 57 and 23 articles were included for the prevalence and BW subreviews, respectively. The pooled estimates of vitamin B-12 insufficiency were 21%, 19%, and 29% in the first, second, and third trimesters, respectively, with high rates for the Indian subcontinent and the Eastern Mediterranean. The large heterogeneity between studies was partially addressed by creating a standardized score for each study (mean vitamin B-12 insufficiency O cutoff value), which internally corrected for geographic region, trimester, and assay type. Twelve of the 13 longitudinal studies included showed a decrease in mean or median vitamin B-12 across trimesters. Pooled analysis showed nonsignificantly lower maternal vitamin B-12 concentrations in LBW than in normal-BW infants and higher odds of LBW with lower vitamin B-12 values (adjusted OR: 1.70; 95% CI: 1.16, 2.50), but studies from India largely contributed to the latter. Conclusions: Our review indicates that vitamin B-12 insufficiency during pregnancy is common even in nonvegetarian populations and that concentrations of vitamin B-12 decrease from the first to the third trimester. There is no consistent association between vitamin B-12 insufficiency and LBW. However, given the long-term risks of LBW, this observation warrants further cohort studies and randomized controlled trials.Am J Clin Nutr 2016;103:1232-51.

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Section: Prevalence Of Vitamin B-12 Insufficiency In Pregnancymentioning

confidence: 97%

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Sukumar

Rafnsson

Kandala

et al. 2016

The American Journal of Clinical Nutrition

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“…Vitamin B12 crosses the placenta during pregnancy and is present in breast milk. Pregnant and lactating women with depleted vitamin B12 stores and their breastfed infants may have very limited reserves of vitamin B12 and such infants can develop vitamin B12 deficiency within months of birth (24,25). Undetected and untreated vitamin B12 deficiency not only increases the risk of NTDs, but it may also result in severe and permanent neurological damage in infants (26).…”

Section: Discussionmentioning

confidence: 99%

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Karabulut¹,

Güler²,

Karahan³

et al. 2015

Turk J Med Sci

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Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods:The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of <12 µg/L, vitamin B12 of <200 pg/mL, and folate of <4 ng/mL were accepted as deficiencies. Hemoglobin level of <12 g/dL was classified as anemia.Results: Polymenorrhea was present in 11.7% and hypermenorrhea in 24.8% of women. Anemia was detected in 24.9% and thalassemia trait in 3.0% of women. Low ferritin levels were observed in 46.1%, vitamin B12 in 21.6%, and folate in 3.4% of women. In the group with low vitamin B12, decreased meat consumption was more prevalent (27.5% vs. 16.9%; P = 0.019). Conclusion:Vitamin B12 and iron are the main micronutrients depleted in our community. This necessitates implementing a public health program for women consuming a Mediterranean diet.

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“…Pregnant women with low vitamin B12 stores can give birth to vitamin B12-deficient neonates 3 , and maternal vitamin B12 stores are thought to be the main determinant of neonatal vitamin B12 status. In addition, if the mother does not consume vitamin B12-containing products adequately after birth or has a disorder causing vitamin B12 deficiency like pernicious anemia, vitamin B12 content of her breast milk will be low, which will further aggrevate the deficiency in the infant if exclusively breast-fed.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Samsun ve Çevresindeki Gebelerde B12 Vitamini Eksikliğinin Sıklığı

Keskin¹,

Demir²,

İğde³

et al. 2014

Cukurova Medical Journal

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Purpose: Vitamin B12 deficiency in infancy can cause severe demyelinating central nervous system disorder. Most cases are exclusively breast-fed infants born to mothers with deficient vitamin B12 stores. As maternal vitamin B12 stores are the main determinant of neonatal vitamin B12 status, we aimed to determine the vitamin B12 status of pregnant women at term in our region. Material and Methods: Serum vitamin B12, folate and plasma homocysteine concentrations in addition to routine testings were measured 1-24 hour(s) before delivery in 62 pregnant women. Besides, infants born to mothers with laboratory evidence of vitamin B12 deficiency were referred to pediatric hematology unit for evaluation. Results: Thirty-six (58.1%) women had a low serum vitamin B12 level (<200 pg/ml). The mean plasma homocysteine was found as 6.82 ± 2.38 µmol/L. Among the 36 neonates whose mothers had a low serum vitamin B12 before delivery, 20 were admitted for examination. Plasma hcy level was not available in four infants. In the remaining 16, 13 (81.3%) had both a decreased vitamin B12 level (<259 pg/ml), and an elevated homocysteine concentration (>9.99 µmol/L). All of the 20 infants examined had normal neurodevelopmental findings. Vitamin B12 supplementation resulted in normalization of vitamin B12 and homocysteine levels in all the cases. Conclusion: The frequency of neonatal vitamin B12 deficiency secondary to maternal deficiency may be higher than thought in Samsun province of Turkey. Large-scale screening studies may reveal its prevalence more accurately, and may help in taking preventive measurements more effectively. Key Words: neonatal, vitamin B12, homocysteine, pregnancy, maternal ÖZET Amaç: B12 vitamini eksikliği, süt çocukluğu döneminde ağır demiyelinizan santral sinir sistemi bozukluğuna neden olabilir. Olguların çoğu, B12 vitamini depoları yetersiz annelerden doğan ve sadece anne sütü ile beslenen bebeklerdir. Yenidoğan bebeklerde, B12 vitamini durumunun temel belirleyicisi, annenini B12 depolarıdır. Bu nedenle, çalışmamızda, bölgemizdeki term gebelerde B12 vitamini durumunu değerlendirmeyi amaçladık. Materyal ve Metod: Toplam 62 gebe kadında, doğumdan 1-24 sa önce rutin tetkiklere ek olarak serum B12, folat ve plazma homosistein değerleri ölçüldü. Ayrıca, B12 eksikliği bulgusu olan annelerin yenidoğan bebekleri değerlendirilmek üzere çocuk hematolojisi polikliniğine yönlendirildi. Bulgular: 36 (%58,1) gebe kadının serum B12 değeri düşük (<200 pg/ml) bulundu. Plazma homosistein (ortalama ± SD) 6,82 ± 2,38 µmol/L olarak hesaplandı. Annesinin serum B12 değeri doğum öncesinde düşük bulunan 36 yenidoğandan 20'si değerlendirildi. 4 bebekte plazma homosistein ölçülemedi. Kalan 16 yenidoğan bebeğin 13'ünde, düşük serum B12 (<259 pg/ml) ve yüksek plazma homosistein ( B12 Deficiency in Pregnancy yenidoğanın tamamının fizik muayene bulguları normaldi. B12 replasmanı sonrasında tüm olgularda serum B12 ve plazma homosistein değerleri normal olarak bulundu. Sonuç: Samsun ve çevresindeki yenidoğanlarda, annedeki eksikliğe ik...

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Serum Vitamin B12 and Folate Concentrations and the Effect of the Mediterranean Diet on Vulnerable Populations

Cited by 30 publications

References 22 publications

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Samsun ve Çevresindeki Gebelerde B12 Vitamini Eksikliğinin Sıklığı

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