Serum Visfatin, Fetuin‐A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity

Okan, Gökhan; Baki, Adile Merve; Yorulmaz, Eda; Doğru‐Abbasoğlu, Semra; Vural, Pervin

doi:10.1002/jcla.21850

Cited by 32 publications

(50 citation statements)

References 33 publications

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“…As alluded to above, epidemiological studies have revealed a positive correlation between psoriasis disease severity and risk of developing T2D . In five of the HOMA‐IR studies mentioned above, the mean PASI of the included patients was high (> 8), reflecting severe disease . These studies all found some sign of impaired glucose metabolism, albeit of differing character.…”

Section: Overview Of the Clinical Studiesmentioning

confidence: 85%

“…These studies all found some sign of impaired glucose metabolism, albeit of differing character. Two studies found a significantly higher HOMA‐IR in the patients with psoriasis than in controls . Two studies showed higher fasting plasma insulin levels or HOMA‐B value but no difference in HOMA‐IR.…”

Section: Overview Of the Clinical Studiesmentioning

confidence: 96%

“…One study even reported a significantly decreased HOMA‐IR in the patient group . Interestingly, only three of eight studies matching for BMI showed significantly increased insulin resistance.…”

Section: Overview Of the Clinical Studiesmentioning

confidence: 99%

“…In total, 17 studies have investigated insulin resistance in patients with psoriasis compared with controls using HOMA‐IR (Table S1; see Supporting Information) . Eight studies found a higher degree of insulin resistance in patients with psoriasis than in controls . Two studies showed inconclusive results (marked with a ‘?’ in Table S1) and six studies found no difference between groups .…”

Section: Overview Of the Clinical Studiesmentioning

confidence: 99%

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Glucose metabolism in patients with psoriasis

et al. 2018

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Summary Background Epidemiological studies strongly suggest that psoriasis predisposes to type 2 diabetes. Several theories have been proposed to explain how these disease entities might be pathophysiologically connected. Objectives Our primary objective was to elucidate whether clinical data support the notion of common pathophysiological denominators in patients with psoriasis and type 2 diabetes, and thus to delineate the association between the two conditions that has arisen on the basis of epidemiological studies. Methods We reviewed clinical studies investigating parameters of glucose metabolism in patients with psoriasis. The PubMed and Embase databases were searched for studies investigating glucose metabolism in adult patients with psoriasis as a primary or secondary end point. Studies had to include a relevant control group. Results Twenty‐six clinical studies reporting on insulin resistance, glucose tolerance or insulin secretion were eligible for review. The results were widely conflicting, with less than half of the studies showing results suggestive of defective glucose metabolism in patients with psoriasis. In general, the studies suffered from a lack of information regarding possible confounders and patient characteristics. Furthermore, the research methods varied, and in all but one study they might not have been appropriate to detect early and subtle defects in glucose metabolism. Conclusions The available literature does not unequivocally support common pathophysiological denominators in psoriasis and type 2 diabetes. Well‐designed clinical studies are needed to expose potential diabetogenic defects in the glucose metabolism in patients with psoriasis.

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Section: Overview Of the Clinical Studiesmentioning

confidence: 85%

Section: Overview Of the Clinical Studiesmentioning

confidence: 96%

Section: Overview Of the Clinical Studiesmentioning

confidence: 99%

Section: Overview Of the Clinical Studiesmentioning

confidence: 99%

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Glucose metabolism in patients with psoriasis

et al. 2018

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“…stwierdzili zwiększone stężenie PTX3 u osób z łuszczycą i sugerują, że może to odzwierciedlać obecny w łuszczycy stan zapalny i insulinooporność [60]. Podobnych spostrzeżeń dokonali także Ctirad i wsp., badając stężenie PTX3 u pacjentów z łuszczycą leczonych miejscowo dziegciami w połą-czeniu z naświetlaniami UV [61].…”

Section: Pentraksynaunclassified