Serum uric acid levels in patients with Parkinson’s disease: A meta-analysis

Wen, Min; Zhou, Bo; Chen, Yunhua; Ma, Zhao-Lei; Gou, Yun; Zhang, Chunlin; Yu, Wenbin; Jiao, Lei

doi:10.1371/journal.pone.0173731

Cited by 90 publications

(73 citation statements)

References 43 publications

(35 reference statements)

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“…Our findings in plasma are consistent with past literature in other neurodegenerative disorders, where lower blood and brain levels of UA have been reported in PD, ALS, and Alzheimer's disease patients (Church and Ward, 1994;Constantinescu and Zetterberg, 2011;Chen et al, 2012;Crotty et al, 2017). In PD, correlations were observed between higher serum levels of UA and not only a lower risk of developing the disease but also a slower rate of disease progression (Schlesinger and Schlesinger, 2008;Paganoni and Schwarzschild, 2017;Wen et al, 2017). Interestingly, studies in PD have also reported differences in men and women, with one study showing correlations between serum UA levels and disease duration in patients with PD only in men (Andreadou et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…Since these early observations, accumulating epidemiological studies, laboratory data, preclinical models, and early clinical trial results have provided substantial support for a neuroprotective role for UA and its potential as a disease biomarker for PD (Constantinescu and Zetterberg, 2011;Chen et al, 2012;Crotty et al, 2017). In particular, UA has been suggested as a promising biomarker of reduced risk and milder progression in PD (Schlesinger and Schlesinger, 2008;Paganoni and Schwarzschild, 2017;Wen et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

et al. 2020

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Oxidative stress has long been implicated in the pathophysiology and progression of Huntington's disease (HD). Uric acid (UA) is a naturally occurring antioxidant that is present in the brain and periphery. Growing evidence has implicated UA as a molecular biomarker for several neurodegenerative diseases, most notably Parkinson's disease (PD). In this study, we investigated UA levels in clinical samples from HD patients and normal controls (NCs) and assessed potential relationships between UA levels and disease and clinical data. UA levels were measured in plasma (n = 107) and saliva (n = 178) samples from premanifest (pre-HD) and manifest HD patients and control subjects. Gender effects of UA levels were observed in both biofluids, with male patients showing higher UA levels compared to female patients. Comparisons of UA levels across diagnostic groups, separated by gender, revealed that both plasma and salivary UA levels were significantly lower in female pre-HD and manifest HD patients compared to NCs. Salivary levels of UA were also significantly lower in male manifest HD patients versus controls, but not in plasma. Correlations of peripheral UA levels to clinical data also showed differences according to gender. In male HD patients, both plasma and salivary UA levels were significantly negatively correlated with total functional capacity (TFC), while positive correlations were observed with total motor score (TMS). Female HD patients showed a significant positive correlation between plasma UA levels and TMS, while salivary UA levels from female patients were significantly correlated to disease burden. Finally, in a separate cohort, we show that UA levels are decreased in postmortem prefrontal cortical samples (n = 20) from HD subjects compared to matched controls. These findings suggest that decreased levels of UA in the brains of HD patients can be reflected in peripheral fluids, with salivary measures of UA particularly offering significant promise as a potentially relevant, non-invasive biomarker of disease symptoms and burden. Our findings further highlight the impact of sexual dimorphism in HD pathophysiology.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients

et al. 2020

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“…Serum uric acid was found to be significantly lower in PD patients compared to controls. No difference was found between the East and West cohorts …”

Section: Analytical Epidemiologymentioning

confidence: 82%

Epidemiology of Parkinson's Disease—East Versus West

Abbas

Tan

2017

Movement Disord Clin Pract

128

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Background: The cause of PD at present remains unknown. A number of epidemiological studies have been conducted across the globe to ascertain the disease burden and the possible risk factors. In this review, we analyze the various studies from East and West with an aim to observe the important similarities and differences in the disease occurrence and risk factor profile. Methods: A comprehensive search of descriptive and analytical epidemiological studies was undertaken. The descriptive studies and meta-analysis providing the standardised population rates were selected. The demographics, ethnicity and geographical differences between East and West were analysed. In analytical epidemiology, more established and well-studied non-genetic risk factors for PD were reviewed utilising the prospective cohort studies, case control studies and meta-analysis where available. Results and Conclusion: PD is more common with increasing age and shows male predominance, which is more obvious in Western studies. The PD prevalence and incidence rates are slightly lower in the East compared to the West. Incidence studies on different ethnic populations in the same country have also found a lower occurrence of PD amongst Easterners compared to Westerners. Setting methodological differences aside, studies from East and West suggest a role for both environmental and genetic risk factors in PD causation. Smoking, caffeine intake and pesticide exposure are well-established risk factors across regions. There is a robust data for dairy product consumption, urate levels and physical activity in the West while studies on certain risk factors like head injury and alcohol show conflicting and mixed results.Parkinson's disease (PD) is the second most common neurodegenerative disorder and in the majority of cases, its cause remains unknown. Epidemiology refers to the study of distribution and determinants of health related events and their application in the control of diseases. 1In descriptive epidemiology, time, place, and person define the health events; while analytical epidemiology helps to identify and quantify the relationship between exposure and a particular health outcome. 1The epidemiological studies determining race and ethnicity help us to understand the roles of, and interaction between, genetic and environmental factors in disease causation. 2In the present review, we analyze the epidemiological features of PD patients between Western and Eastern countries. The division of East and West is not clear, as the definition varies depending on whether historical, geographical, economic, cultural, or political factors are considered. In this review, we have adopted the cultural definition that considers Asia, and the Middle East as "Eastern" countries; Russia, Europe, the Americas, Australia, and New Zealand as "Western" countries. West studies. In addition, the results of relevant meta-analysis were also discussed.There are a number of PD descriptive epidemiology studies in the literature. The comparison of these studies rem...

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“…Проте сучасні дослідження демонструють, що сечова кислота може діяти як антиоксидант при хворобі Паркінсона (ХП) та інших нейродегенеративних захворюваннях [2]. Вона здійснює нейропротекторну дію за допомогою ефективної нетралізації радикалів кисню та азоту в сироватці крові та клітинах мозку [3]. За даними проспективних досліджень виявлено, що високий вміст сечової кислоти у сироватці крові знижував ризик розвитку ХП [4].…”

Section: вступunclassified