Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: A meta-analysis of cohort studies

Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome: Results from Fangchenggang Area Male Health and Examination Survey in China

“…A metaanalysis of cohort studies indicated that SUA concentrations were positively associated with incidence of impaired fasting glucose and type 2 diabetes [20]. However, the present study showed that increased concentrations of SUA did not lead to the increased glucose concentration (HR = 1.34, 95% CI, 0.93-1.95, P = NS).…”

Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

“…Some genes associated such as the SLC2A9 gene [encodes uric acid and glocose transporter] [11] and Uric acid-associated genes have an impact on the risk of T2D, glucose metabolism, insulin secretion and metabolic syndrome [12,13]. Additionally to genetic findings some studies have emphasized that elevated serum uric acid [SUA] levels are positively associated with the development of type 2 diabetes itself [17], impaired fasting glucose [18] and 2-hour postload glucose [19]. Elevated SUA stated as an independent predictor of vascular complications and mortality in type 2 diabetes mellitus patients [14] and is associated with excess risk for development of the disease [15,16].…”

Behavior of the total antioxidant status in a group of subjects with metabolic syndrome

“…A relationship between hyperuricemia and various MS components (hypertension, obesity, diabetes mellitus) has been demonstrated [36][37][38][39] and serum uric acid levels seem to be clearly associated with the prevalence of MS [36] and the incidence of DM [40]. In addition, in type 2 diabetic subjects hyperuricemia is correlated with the vascular complications, such as retinopathy, cerebrovascular and coronary artery diseases, and nephropathy [41].…”

“…In the last years a paradoxal role of uric acid has been hypothesized as it could act as an antioxidant in plasma and extracellular environment and as a pro-oxidant within the cells [40,42]; it is not possible to exclude that MS subjects with type 2 diabetes mellitus were hyperuricemic but we know the serum uric acid levels of a small group of MS subjects (data not shown).…”