Behavior of the total antioxidant status in a group of subjects with metabolic syndrome

Hopps, Eugenia; Canino, Baldassare; Montana, M.; Presti, Rosalia Lo; Averna, Maurizio; Caimi, Gregorio

doi:10.1016/j.dsx.2014.04.013

Cited by 7 publications

(4 citation statements)

References 46 publications

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“…In studies made with commercial kits based on the method of Miller et al, Glantzounis et al [ 34 ] and Zulfikaroglu et al [ 35 ] observed significant decreased TAC values in human patients submitted to laparoscopic cholecystectomy. Patients with metabolic syndrome [ 36 ] and with prediabetes [ 37 ] showed TAC values significantly lower than healthy subjects. In addition, non-surviving septic patients had higher serum TAC levels than surviving ones [ 38 ].…”

Section: Teac Assaymentioning

confidence: 99%

Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update

et al. 2016

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The aim of this review is to study the main spectrophotometric methods used to evaluate total antioxidant capacity (TAC) in serum samples of dogs. Total antioxidant capacity (TAC) is an analyte frequently used to assess the antioxidant status of biological samples and can evaluate the antioxidant response against the free radicals produced in a given disease. Trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), and cupric reducing antioxidant capacity (CUPRAC) are different assays described to determine TAC of a sample. This review explains the basis of each assay and their application in the determination of TAC in dogs, and also provides selected information about reports in humans for comparative purposes. It is concluded that, ideally, various different assays integrated in a panel should be used for TAC evaluation, since depending on the assay performed TAC results can be markedly different.

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Section: Teac Assaymentioning

confidence: 99%

Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update

et al. 2016

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“…While some articles stated that TAC decreased in T2D, another reported that they observed an increase [6,9,17,18]. In a study of patients with Metabolic Syndrome (MS), they found a significant reduction in TAC in MS compared to normal subjects, but this decrease was not seen among normal and diabetic subjects with MS [19]. However, there have been some arguing that OS contributes to the formation of atherosclerotic plaques and the increased risk of Cardiovascular Disease (CVD) in diabetic patients [20].…”

Section: Discussionmentioning

confidence: 98%

Is Oxidative Stress a Consequence of Hyperglycemia? Or is Hyperglycemia the Consequence of Oxidative Stress? Or are Both Caused by Insulin Resistance?

Boyacı¹,

Türkan²,

Handan³

2021

Int Arch Endocrinol Clin Res

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“…The brain content of advanced glycation end products (AGEs) and protein carbonyl group (PCG) were determined according to Koschinsky et al and Hopps et al [23,24]…”

Section: Biochemical Analysismentioning

confidence: 99%

Comparative Study between Saffron (Crocus sativus L.) and / or Turmeric (Curcuma longa L.) Extracts on D-galactose Deleterious Brain Effects in Rats

Ahmed

Baker

Gabal

2021

JPRI

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Aims: This study was designed to investigate the active chemical constituents and antioxidant capacities of saffron stigmas and turmeric rhizomes ethanolic extracts (ESE and ETE) respectively. D- galactose deleterious brain effects as well as the role of ESE and ETE supplementation against D-galactose intoxication were evaluated on male rat’s brain. Place of study: Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams University. Methodology: Fifty adult male Sprague-Dawley rats were divided into 5 groups; 10 rats each. Group (1): Healthy control; group (2): D-galactose control; rats were intoxicated with D-galactose (250mg/kg body weight /day/subcutaneously); group (3-5): D-galactose intoxicated rats and supplemented with (30mg /kg body weight /daily orally) of ESE, ETE and (15mg /kg body weight /daily orally) from each extract respectively for six weeks. Results: Research results revealed that saffron and turmeric ethanolic extracts contain active chemical constituents including polyphenols and flavonoids that possess high antioxidant activity. Biochemical analysis of brain tissues documented that injection with D-galactose caused significant increase (p≤0.05) in oxidative stress parameters including [advanced glycation end products (AGEs), protein carbonyl group (PCG), malondialdehyde (MDA) and nitric oxide (NO) Levels], pro-inflammatory markers like [tumor necrosis factor alpha (TNF-α) and interleukin -6 (IL-6) levels] , epigenetic marker [p16INK4a content] as well as neural cell markers [metallothoenins (MTs) and serotonin (5-HT) levels].On the other hand D-galactose intoxication caused significant decrease (p≤0.05) in brain antioxidants as [total antioxidant capacity (TAC), reduced glutathione (GSH) level and catalase (CAT) activity] as well as brain acetylcholinesterase (AChE) activity. All these results were proved by the microscopic examination and apoptotic markers immunohistochemical analysis of brain tissues that revealed degenerative changes in cerebral cortex and hippocampus. Oral administration of saffron and turmeric ethanolic extracts alone or in combination decreased brain oxidants, pro-inflammatory markers, epigenetic marker and neural cell markers levels while increased the levels and activities of antioxidants as well as AChE activity associated with an improvement of brain microscopic examination and immunohistochemical analysis. The most significant improvements (p≤0.05) were recorded in the group that supplemented with both extracts. Conclusion: Study results proved that saffron and turmeric ethanolic extracts active components were able to correct deleterious brain effects induced by D-galactose and using their mixture was more efficient in ameliorating brain toxicity than using each extract alone evidenced by biochemical analysis, microscopic examination as well as immunohistochemical determination of apoptotic markers in bmrain tissues. It is advised to add saffron and turmeric to human foods and to prepare their ethanolic extracts to be available for human beings due to their ability to preserve brain functions and structure as well as their potential to inhibit and retard brain aging and neuro-degeneration.

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Behavior of the total antioxidant status in a group of subjects with metabolic syndrome

Cited by 7 publications

References 46 publications

Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update

Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update

Is Oxidative Stress a Consequence of Hyperglycemia? Or is Hyperglycemia the Consequence of Oxidative Stress? Or are Both Caused by Insulin Resistance?

Comparative Study between Saffron (Crocus sativus L.) and / or Turmeric (Curcuma longa L.) Extracts on D-galactose Deleterious Brain Effects in Rats

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