Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study

Atar, Asli; Yılmaz, Ömer; Akın, Kayıhan; Selçoki, Yusuf; Er, Okan; Eryonucu, Beyhan

doi:10.5152/akd.2013.039

Cited by 16 publications

(39 citation statements)

References 35 publications

(42 reference statements)

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“…Clinical research has also shown that correlations between the higher serum uric acid levels and calcification of the coronary artery [17], the decreased flow-mediated dilation, which indicates the vascular endothelial function [18] and higher pulse wave velocity [19], suggest that hyperuricemia is associated with arteriosclerosis. It is almost certain that hyperuricemia induces arteriosclerosis and hypertension.…”

Section: Hyperuricemia and Hypertensionmentioning

confidence: 99%

Hyperuricemia, Cardiovascular Disease, and Hypertension

Kuwabara¹

2015

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128

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In recent years, there has been an increase in the prevalence of hyperuricemia, and the latter has attracted attention as an adult lifestyle-associated disease, together with hypertension, diabetes, and dyslipidemia. Although hyperuricemia is known to be an independent risk factor for hypertension, whether it is an independent risk factor for cardiovascular disease remains controversial. Recently, some small-scale interventional studies on antihyperuricemic medications showed that the latter improved angina symptoms and prevented cardiovascular disease. Here, we will mainly explain the cause of hyperuricemia and the associations between hyperuricemia, hypertension, and cardiovascular disease based on the latest published evidence.

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Section: Hyperuricemia and Hypertensionmentioning

confidence: 99%

Hyperuricemia, Cardiovascular Disease, and Hypertension

Kuwabara¹

2015

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128

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“…The average age of participants ranged from 36.5 to 84.5 . There are one case control, three cohorts, and seven cross‐sectional studies in total. Of these studies, nine included both genders, one included only men, and one included only women .…”

Section: Resultsmentioning

confidence: 99%

“…Three cohort studies reported the association between hyperuricemia and CAC progression. All of the selected studies were assessed as high quality according to the NOS scale (10 studies have NOS scores as 9 and 1 study as 8). See Table .…”

Section: Resultsmentioning

confidence: 99%

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta‐analysis

Liang

Hou

Bainey

et al. 2019

Clinical Cardiology

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Hyperuricemia coincides with coronary artery calcification (CAC) development, but the role of serum uric acid (SUA) as a risk factor for CAC remains unclear. The objective of this study was to gain an insight into the association between SUA and CAC in adults by performing a meta‐analysis. MEDLINE, EMBASE, the Cochrane Library, and EBSCO (CINAHL) were searched for relevant observational studies published until 2 June 2019. Studies were included only if they reported data on CAC presence (Agatston score > 0) or progression related to hyperuricemia in subclinical adult patients. The pooled estimates of crude and adjusted odds ratios (ORs) and 95% confidence interval (CI) were calculated to evaluate the association between CAC presence or progression and hyperuricemia. A total of 11 studies were identified involving 11 108 adults. The pooled OR based on the frequency of CAC presence showed that patients in the high SUA group had 1.806‐fold risk for developing CAC (95% CI: 1.491‐2.186) under the minimal threshold of hyperuricemia (more than 6 mg/dL or 357 μmoL/L). When SUA levels were analyzed as categorical variables, the pooled estimate of adjusted ORs was 1.48 (95% CI: 1.23‐1.79) for CAC presence. Additionally, for each increase of 1 mg/dL of SUA level, the risk of CAC progression was increased by 31% (95% CI: 1.15‐1.49) with an average follow‐up duration ranged from 4.6 to 6.1 years. Hyperuricemia is closely associated with increased risk of CAC development and CAC progression in asymptomatic patients.

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“…Serum UA was found to be an independent risk factor for the presence of CAC in a group of 442 patients who were evaluated for suspected CHD …”

Section: Discussionmentioning

confidence: 98%

“…Several studies have demonstrated a relationship between serum UA levels and CAC score, but other studies do not support these findings …”

mentioning

confidence: 88%

Serum Uric Acid Is Associated With Coronary Artery Calcification

Grossman

Shemesh

Koren‐Morag

et al. 2014

J of Clinical Hypertension

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Uric acid (UA) is associated with atherosclerosis, and coronary artery calcium (CAC) is a marker of atherosclerosis. The authors studied the association between UA and CAC. A total of 663 asymptomatic patients (564 men; mean age, 55±7 years) were evaluated for the presence of CAC. The study population was divided into three tertiles according to their UA levels, and the prevalence of CAC was compared between the tertiles. CAC was detected in 349 (53%) patients. Levels of UA were significantly higher in those with CAC than in those without CAC (5.6+1.2 vs 5.3+1.3; P=.003). The odds ratio for the presence of CAC in the highest vs lowest UA tertile was 1.72 (95% confidence interval, 1.17–2.51). The highest UA tertile remained associated with the presence of CAC after adjustment for known cardiovascular risk factors. The results show that high serum UA levels are associated with the presence of CAC.

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Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study

Cited by 16 publications

References 35 publications

Hyperuricemia, Cardiovascular Disease, and Hypertension

Hyperuricemia, Cardiovascular Disease, and Hypertension

The association between hyperuricemia and coronary artery calcification development: A systematic review and meta‐analysis

Serum Uric Acid Is Associated With Coronary Artery Calcification

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