The association between hyperuricemia and coronary artery calcification development: A systematic review and meta‐analysis

Liang, Ling; Hou, Xianghua; Bainey, Kevin R.; Zhang, Yanlin; Tymchak, Wayne; Qi, Zhongquan; Li, Weihua; Banh, Hoan Linh

doi:10.1002/clc.23266

Cited by 22 publications

(14 citation statements)

References 40 publications

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“…This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [ 19 ]. A protocol was not registered, since it is not mandatory, as per several recommendations [ 20 , 21 ]. On 26 July 2022, PubMed, Scopus, Web of Science, and Google Scholar were searched for articles that report the presentation of EES in the pediatric population (children and young adolescents <21 years of age).…”

Section: Methodsmentioning

confidence: 99%

Extraosseous Ewing Sarcoma in Children: A Systematic Review and Meta-Analysis of Clinicodemographic Characteristics

Ghandour

Lehner

Klotz³

et al. 2022

Children

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Background: We conducted this systematic review to provide comprehensive evidence on the prevalence, clinical features and outcomes of young extraosseous Ewing sarcoma (EES) cases. Methods: PubMed, Scopus, Web of Science, and Google Scholar were searched for articles reporting the occurrence of EES among children and adolescents (<21 years). The primary outcome included the rate of occurrence of EES among children and adolescents, while the secondary outcomes included the descriptive analyses of the demographic characteristics, tumor characteristics, and clinical outcomes of the affected cases. The data are reported as the effect size (ES) and its corresponding 95% confidence interval (CI). Results: A total of 29 studies were included. Twenty-four reported instances of childhood disease among all the EES cases [ES = 30%; 95%CI: 29–31%], while five studies reported extraosseous cases among the pediatric EES cases [ES = 22%; 95%CI: 13–31%]. The thorax is the most common location of childhood EES [33%; 95%CI: 20–46%] followed by the extremities [31%; 95%CI: 22–40%]. Concurrent chemotherapy and radiotherapy [57%; 95% CI: 25–84%] was the most commonly implemented management protocol in the pediatric EES cases. The rate of no evidence of disease and 5-year overall survival was 69% for both outcomes. Mortality occurred in 29% of cases, while recurrence and secondary metastasis occurred in 35% and 16% of cases, respectively. Conclusions: Our findings provide insight into the clinical features and outcomes of EES among children and adolescents.

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Section: Methodsmentioning

confidence: 99%

Extraosseous Ewing Sarcoma in Children: A Systematic Review and Meta-Analysis of Clinicodemographic Characteristics

Ghandour

Lehner

Klotz³

et al. 2022

Children

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“…Previous meta-analyses have identified a correlation between uric acid levels and a variety of CHD outcomes. Previous research by 5 revealed a correlation between uric acid levels and the risk of poor clinical outcomes in the form of coronary artery calcification in the CHD patient population; with every 1 mg/dl uric acid increase, the risk of CAC increased by 31%. Furthermore, the study by 12 found a correlation between uric acid levels and the prognosis of CHD mortality; with every 1 mg/dl uric acid increase, mortality increased by 9%, but the missing adjustment needed for diuretic use and renal functioning was identified as a shortcoming in their meta-analysis.…”

Section: Discussionmentioning

confidence: 96%

“…It is not clear how uric acid is correlated with CHD, but several studies suggest that elevated uric acid, also known as hyperuricemia, increases CHD risk by inducing endothelial dysfunction, oxidative stress, and interconnected inflammatory mechanisms. 5 , 6 The clinical manifestations of CHD contribute to increased circulating uric acid levels in the arterial tissue, including coronary arteries. 7 Impaired tissue reperfusion due to CHD activates circulating xanthine oxidase enzymes in the endothelium, leading to an increase in uric acid levels and, as a result, endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Maulana¹,

Nuraeni²,

Nugraha³

2022

JMDH

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Background This study sought to determine whether uric acid levels have a relationship with and can potentially be used as a prognosis for coronary heart disease (CHD) biomarkers using a scoping review. Methods This study was conducted following Arksey and O’Malley’s scoping review framework. It was reported as obeying the Preferred Reporting Item for Systematic Review and Meta-analysis for Scoping Review (PRISMA-ScR). The subject was extensively searched for in PubMed, CINAHL, and ScienceDirect. The inclusion criteria in the study were that the sources were journal articles written in English and were available in full text. The age of the subject in the item is the elderly population to capture the relationship between uric acid levels and the prognosis of CHD. The publication time limit was 2010 to 2020. The study was analyzed using thematic analysis. Results We identified 592 studies in our initial search, and 21 studies with a cohort design were included in this study’s analysis. The majority of the evidence suggests an independent correlation with a poor prognosis of CHD in the elderly population. The prognosis of gout includes the prognosis of clinical outcome, severity, and mortality, all of which influence the prognosis value, which becomes a marker. Conclusion Uric acid levels have been identified as a potential biomarker for poor CHD prognosis. Nurses and other healthcare workers should learn how to control poor CHD prognosis.

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“…Another study was found a positive relationship between serum UA and CAC in 663 asymptomatic middle-aged patients 12 . A recent systematic review and meta-analysis reported that serum UA is associated with increased risk of CAC development and progression in asymptomatic subjects [1,28] and is an independent predictor for the development of moderate CAC in subjects with no or minimal CAC [29]. Although the molecular mechanism is not fully understood, it is suggested that UA as pro-oxidant may stimulate VSMC production of superoxide radical by COX-2 and thus contribute to atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Hyperuricemia as a Potential Metabolic Risk Factor for Coronary Artery Calcification in Patients With Atrial Fibrillation or Heart Failure

Pasheva¹,

Yotov²,

Nikolova³

et al. 2021

JofIMAB

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Purpose: To assess the role of asymptomatic hyperuricemia for the presence and severity of coronary arterial calcium (CAC) in adults with different cardiovascular (CV) pathology and its association with conventional CV risk factors. Material/Methods: Adults (n=81) of both genders were divided into controls: with moderate- to high risk without known CVD; AF-group: CVD-patients with paroxysmal or persistent atrial fibrillation in sinus rhythm, HF–group: heart failure subjects with preserved ejection fraction. A structured interview was performed at admittance for evaluation of the classical CVD risk factors. CAC score (CACS) was determined by multislice computed tomography. Routine laboratory parameters, including uric acid (UA), were extracted from medical documentation. Descriptive statistics, Mann-Whitney U-test, one-way ANOVA, chi-square test, Spearman's correlation, and multiple linear regression analysis were applied. The predictive power of serum UA was evaluated using receiver operating characteristic (ROC) analysis. Statistical significance was considered at p<0.05. Results: Serum UA was significantly higher in subjects with CACS=1-99AU (p=0.030), and with CACS≥100AU (p=0.067) vs. patients without CACS. Within the UA tertiles, highest CACS was found in the tertile with highest serum UA. UA revealed positive relation with CACS (r=0.35, p=0.002), age (r=0.25, p=0.027), body mass index (0.27, p=0.017), waist circumference (r=0.44, p<0.0001), triglycerides (r=0.29, p=0.001), and creatinine (r=0.54, p<0.0001). Multiple linear regression analysis revealed significant association between UA as dependent variable and waist circumference (β=0.63, p=0.061), serum triglycerides (β=0.37, p=0.028), creatinine levels (β=0.45, p<0.0001). Conclusions: Asymptomatic hyperuricaemia could be an important metabolic factor negatively affecting the chronic cardio-vascular pathology besides the conventional risk factors.

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The association between hyperuricemia and coronary artery calcification development: A systematic review and meta‐analysis

Cited by 22 publications

References 40 publications

Extraosseous Ewing Sarcoma in Children: A Systematic Review and Meta-Analysis of Clinicodemographic Characteristics

Extraosseous Ewing Sarcoma in Children: A Systematic Review and Meta-Analysis of Clinicodemographic Characteristics

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Asymptomatic Hyperuricemia as a Potential Metabolic Risk Factor for Coronary Artery Calcification in Patients With Atrial Fibrillation or Heart Failure

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