Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study

Huang, Xinxin; Ng, Samuel Yong‐Ern; Chia, Nicole Shuang Yu; Acharyya, Sanchalika; Setiawan, Fiona; Lu, Zejun; Ng, Ebonne Yulin; Tay, Kay Yaw; Au, Wing Lok; Tan, Eng‐King; Tan, Louis C.S.

doi:10.1016/j.parkreldis.2018.05.010

Cited by 58 publications

(72 citation statements)

References 26 publications

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“…In one study, it was observed that there was an improvement in neurologic deficit when albumin was administered following acute intracortical hematoma (36). In various studies, serum albumin concentrations were found to be significantly reduced as the disease progressed (22). Similarly, the data of our study showed that serum albumin concentrations in patients with IPD decreased significantly in parallel with the increase in the disease stage.…”

Section: Discussionsupporting

confidence: 70%

“…Homocysteine, uric acid (UA), albumin, and bilirubin are defined as laboratory parameters associated with oxidative stress. Low UA, albumin, and bilirubin concentrations were associated with many neurodegenerative diseases, including PD, but these changes in their concentrations as oxidative stress markers were not clarified as to whether they caused neurodegenerative diseases or they were results of the underlying process in the literature (7,17,18,19,20,21,22). Several studies showed that there was a correlation between hypoalbuminemia and increased CRP concentrations and other acute phase proteins (34).…”

Section: Discussionmentioning

confidence: 99%

“…toxins, free radicals, dysfunctions in the ubiquitin/proteasome system) can lead dopaminergic cells to undergo apoptotic death (8,9). Serum C-reactive protein (CRP) and albumin concentrations have recently been used as markers of systemic inflammation and oxidative stress in different diseases (7,10,11,12,13,14,15,16,17,18,19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Yazar¹,

Yazar²

2019

tnd

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Objective: Identification of serum C-reactive protein (CRP)/albumin ratio according to disease stage in idiopathic Parkinson's disease (IPD) with the aim of collecting data about the role of inflammation and oxidative stress in etiopathogenesis and about CRP/albumin ratio's possible effects on disease progression. Materials and Methods: The study was completed with 151 patients being staged according to the Modified Hoehn and Yahr (H&Y) criteria and 150 healthy volunteers in the same age interval with patients. In our retrospective study, the Unified Parkinson disease rating scale (UPDRS) and H&Y scales were applied to the patients with IPD diagnosed according to the diagnostic criteria of the "United Kingdom Parkinson Disease Society Brain Bank". Patient and control groups had venous blood samples taken for biochemical study after 12-14 hours of fasting. Results: The serum albumin levels were lower, while serum CRP levels and CRP/albumin ratios were higher in the IPD group (p<0.05) than in the control group. Serum levels of CRP/albumin ratio significantly increased in parallel with the progression of disease stage (p<0.05). Conclusion: Our study supports the hypothesis that serum CRP/albumin ratio may be associated with the etiopathogenetic process of IPD as a biomarker of inflammation and oxidative stress. In order to detect chronic and progressive diseases such as IPD in the initial stages and to take precautions, it is important to evaluate the changes in easily accessible, cost-effective parameters such as serum CRP/albumin ratio.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Yazar¹,

Yazar²

2019

tnd

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“…One hundred sixty early PD patients (63.56 ± 8.73 years old; 58.8% male) with disease duration less than 2 years were recruited as per PALS (Early Parkinson's Disease Longitudinal Singapore) study protocol …”

Section: Serum Tg Level and Its Associations With Pd‐mci As Well As Cmentioning

confidence: 99%

Higher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment

Huang

Chia

et al. 2018

Movement Disorders

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“…Serum uric acid (SUA) is a purine metabolism product. Some studies have shown that SUA may be an important biomarker for specific motor features (7). Its association with diabetic peripheral neuropathy (8), cardiovascular diseases (9,10), ischemic stroke (11) and many other clinical syndromes was reported.…”

Section: Introductionmentioning

confidence: 99%

Predictive Values of Serum Uric Acid, Mean Platelet Volume and Plateletcrit on Benign Paroxysmal Positional Vertigo

Evrın¹,

Katipoğlu²

2019

Eurasian J Emerg Med

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Aim: There are conflicting study results on correlation of serum uric acid (SUA) with benign paroxysmal positional vertigo (BPPV). In this study, it was aimed to evaluate predictive values of SUA, mean platelet volume (MPV) and plateletcrit (PTC) on BPPV. Materials and Methods: After the approval of the ethics committee, the files of all patients with BPPV who were admitted to the Emergency Department of Ufuk University between 01.01.2015 and 01.01.2016 were examined retrospectively. White blood cell, MPV, PTC and SUA levels of patients were evaluated. Results: There was no statistically significant difference between the groups in terms of gender distribution (p>0.05). The mean age of the control group (31.25±11.46 years) was lower than the vertigo group (44.71±19.38 years), but this difference was not statistically significant (p>0.05). The difference between two groups in terms of MPV, PTC and SUA parameters was statistically significant (p<0.05). The sensitivity was found to be 92.1% and the specificity was 47.8%. For a PTC value of 0.224%, the sensitivity was 23.7% and the specificity was 87%. For SUA, area under curve was 71.6% indicating that SUA had a predictive value for peripheral vertigo (p<0.01). The sensitivity of SUA was 55.3% and the specificity was 21.7% for a SUA value of 4.1. The sensitivity of SUA was 15.8 and the specificity was 87% for a SUA value of 6.55. Conclusion: Analysis results were in accordance with volume ure in which SUA is suspected in idiopathic BPPV. In addition, PTC was also correlated with BPPV.

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Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study

Cited by 58 publications

References 26 publications

Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Evaluation of C-reactive Protein/Albumin Ratio According to Stage in Patients with Idiopathic Parkinson Disease

Higher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment

Predictive Values of Serum Uric Acid, Mean Platelet Volume and Plateletcrit on Benign Paroxysmal Positional Vertigo

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