Serum uric acid in hypertensive patients with and without peripheral arterial disease

Langlois, Michel; Bacquer, Dirk De; Duprez, Daniel; Buyzere, Marc De; Delanghe, Joris; Blaton, V.

doi:10.1016/s0021-9150(03)00093-5

Cited by 51 publications

(39 citation statements)

References 33 publications

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“…association between mild hyperuricemia and TOD 11,26,27 have been scanty. To our knowledge, the present study is the first to systematically investigate the relationship between SUA and cardiovascular and renal abnormalities, ie, LVH, carotid atherosclerosis, and microalbuminuria in patients with primary hypertension.…”

Section: Viazzi Et Al Serum Uric Acid and Hypertensive Organ Damagementioning

confidence: 99%

“…14 -16 Several pathophysiological mechanisms linking SUA to cardiovascular damage at the cellular and tissue level have been proposed, including proliferation of vascular smooth muscle cells, 17 stimulation of the inflammatory pathway, 18 and possible prothrombotic effects mediated by platelet activation. 19 In addition, uric acid has proved to be an excellent marker for tissue ischemia and endothelial dysfunction, 11,20 and it has been shown to play a role in the development of atherosclerotic lesions. 21 The presence of subclinical hypertensive organ damage signals a condition of increased risk for cardiovascular and renal morbidity and mortality.…”

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Serum Uric Acid and Target Organ Damage in Primary Hypertension

et al. 2005

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Abstract-The role of serum uric acid as an independent risk factor for cardiovascular and renal morbidity is controversial.A better understanding of its relationship with preclinical organ damage may help clarify the mechanism(s) implicated in the development of early cardiovascular disease. We evaluated the association between uric acid and the presence and degree of target organ damage in 425 (265 males, 160 females) middle-aged, untreated patients with essential hypertension. Left ventricular mass index and carotid intima-media thickness were assessed by ultrasound scan. Albuminuria was measured as the albumin to creatinine ratio in 3 nonconsecutive first morning urine samples. Overall, patients with target organ damage had significantly higher levels of serum uric acid as compared with those without it (presence versus absence of left ventricular hypertrophy, Pϭ0.04; carotid abnormalities, PϽ0.05; microalbuminuria, PϽ0.004; and at least 1 versus no organ damage, PϽ0.03). In women, the occurrence and severity of each target organ damage we examined increased progressively from the lower to the upper serum uric acid tertiles (PϽ0.01). After adjustment for body mass index, age, creatinine clearance, and high-density lipoprotein cholesterol, each standard deviation increase in serum uric acid entailed a 75% higher risk of having cardiac hypertrophy and a 2-times greater risk of having carotid abnormalities. These results support the role of serum uric acid as an independent, modifiable marker of cardiovascular damage.

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Section: Viazzi Et Al Serum Uric Acid and Hypertensive Organ Damagementioning

confidence: 99%

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confidence: 99%

Serum Uric Acid and Target Organ Damage in Primary Hypertension

et al. 2005

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“…1) is the final oxidation product of purine metabolism in humans and other higher primates. The concentration levels of uric acid in serum and urine are associated with various diseases, such as cardiovascular disease, renal disease, diabetes, and hypertension, [1][2][3][4][5][6][7][8][9] and are routinely determined especially in clinical and biomedical laboratories. Creatinine ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Creatinine and Uric Acid in Human Urine by High-Performance Liquid Chromatography

et al. 2008

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An environmentally friendly reversed-phase HPLC method for simultaneous determination of creatinine and uric acid in human urine samples has been developed. Human urine samples were pretreated by dilution, protein precipitation, centrifugation and filtration, followed by HPLC separations using a reversed-phase C18 column with an aqueous mobile phase of phosphate buffer. The retention loss of a C18 column when using the highly aqueous mobile phases was avoided by employing a gradient elution using a small volume (<0.23 mL) of acetonitrile and phosphate buffer at pH 4.75. This developed method provides a simple, rapid separation and sensitive detection for the species of interest in 10 min with UV detection at 205 nm. Quantitation was carried out by relating the peak areas of the identified compounds to that of hypoxanthine as an internal standard. The detection limits for creatinine and uric acid were 0.045 and 0.062 mg mL -1 , respectively. The recoveries of the standards added to urine samples were 87.3 -102.2% for creatinine and 97.3 -108.6% for uric acid, and the relative standard deviation for both analytes was less than 1.0%. This method has been successfully applied to estimating of creatinine and uric acid in human urine.

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“…Diversos estudios clínicos y epidemiológicos han comprobado la relación entre los niveles de ácido úrico y varias enfermedades cardiovasculares, como la hipertensión arterial 51,52 , síndrome metabólico 53,54 , enfermedad coronaria 55,56 , preeclampsia 57 , enfermedad renal 58,59 e insuficiencia cardiaca aguda 17 y crónica 13,[16][17][18]60 . al respecto, la relación entre ácido úrico e insuficiencia cardiaca ha sido observada a partir de niveles plasmáticos relativamente normales de ácido úrico (> 5,2 mg/dL) y no sólo en aquellos pacientes con hiperuricemia reconocida (niveles de ácido úrico > 6 mg/dL en mujeres y > 7 mg/dL en hombres).…”

Section: Estudios Clínicos Y Epidemiológicosunclassified

Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca

et al. 2011

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[1][2][3] . actualmente, la insuficiencia cardiaca (Ic) se entiende como un proceso clínico muy complejo, caracterizado por un inadecuado funcionamiento ventricular y una serie de alteraciones neurohormonales que impiden al corazón suplir las necesidades metabólicas mínimas de los tejidos periféricos, traduciéndose en el establecimiento de estrés oxidativo e inflamación 4 . Sólo en los últimos años se ha estudiado la importancia pronóstica y terapéutica de los trastornos metabólicos a nivel cardiovascular [5][6][7] . Entre éstos, ha adquirido alto interés el estudio de las alteraciones del metabolismo del ácido úrico 8,9 . Hasta la fecha, no existe un consenso acerca del papel del ácido úrico en la Ic. Por una parte, diversos estudios básicos y clínicos sugieren que participa activamente en su génesis y progresión [10][11][12][13][14][15][16][17][18] , mientras otras investigaciones postulan una acción beneficiosa del ácido úrico a través de una actividad antioxidante [19][20][21][22][23][24][25] . Esta revisión discute cómo esta molécula puede ser tanto deletérea como benéfica. Para ello, se describirá la biología del ácido úrico, se presentarán y analizarán sus efectos deletéreos y beneficiosos y, finalmente, se sugieren algunos mecanismos que permiten explicar su acción paradójica en el sistema cardiovascular.

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Serum uric acid in hypertensive patients with and without peripheral arterial disease

Cited by 51 publications

References 33 publications

Serum Uric Acid and Target Organ Damage in Primary Hypertension

Serum Uric Acid and Target Organ Damage in Primary Hypertension

Simultaneous Determination of Creatinine and Uric Acid in Human Urine by High-Performance Liquid Chromatography

Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca

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