Serum uric acid and metabolic syndrome in Taiwanese adults

Liu, Pei-Wen; Chang, Tsui-Yen; Chen, Jong-Dar

doi:10.1016/j.metabol.2009.09.027

Cited by 60 publications

(42 citation statements)

References 28 publications

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“…Therefore, most physicians believe that asymptomatic hyperuricemia does not need any treatments. However, since hyperuricemia is considered a risk factor for cardiovascular disease (9,10,38), and it has been associated with metabolic syndrome components including obesity, diabetes mellitus, lipid abnormalities, and hypertension in some studies (12,(39)(40)(41)(42)(43), prevention should be prioritized. The current study suggested that it is important to prevent asymptomatic hyperuricemia through dietary pattern modifi cations to reduce the risk of related diseases or serious consequences such as cardiovascular disease and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Major Dietary Patterns and Risk of Asymptomatic Hyperuricemia in Chinese Adults

Zhang

Chang

Gao

et al. 2012

J Nutr Sci Vitaminol

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SummaryIn this study, we conducted a case-control study to evaluate the association of major dietary patterns and asymptomatic hyperuricemia taking account of blood lipids in Chinese adults. 187 cases with confi rmed asymptomatic hyperuricemia and 187 controls were frequency matched on age, gender and area of residence. We conducted factor analysis using dietary information from a validated food frequency questionnaire to derive dietary patterns. The association between major dietary patterns and asymptomatic hyperuricemia was assessed by logistic regression analysis. Three major dietary patterns were found: 1) "animal products and fried food," 2) "western," 3) "soybean products and fruit." In multivariate analyses the "animal products and fried food" pattern score was associated with an odds ratio (OR) of 2.15 (95% CI, 1.22-3.76) compared with the lowest tertile. The OR for the top tertile of score for "soybean products and fruit" pattern was 0.32 (95% CI, 0.19-0.57) compared with the lowest tertile of "soybean products and fruit" pattern score. The significant association of these two patterns and asymptomatic hyperuricemia persisted after further adjusting for blood lipids. On the other hand, the "western" pattern was not associated with asymptomatic hyperuricemia. We observed a positive relationship between the "animal products and fried food" pattern and asymptomatic hyperuricemia, and a negative relationship between the "soybean products and fruit" pattern and asymptomatic hyperuricemia, independent of blood lipids.

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Section: Discussionmentioning

confidence: 99%

Major Dietary Patterns and Risk of Asymptomatic Hyperuricemia in Chinese Adults

Zhang

Chang

Gao

et al. 2012

J Nutr Sci Vitaminol

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“…In a Korean population, Yoo et al found that SUA independently correlated with all the MS components [8]. In a Taiwan study, Liu et al observed that the influence of hypertriglyceridemia was greater on SUA, followed by low HDL and Hypertension, but did not find an association with glucose intolerance or abdominal obesity [9].…”

Section: Discussionmentioning

confidence: 99%

Association of Metabolic Syndrome with Asymptomatic Hyperuricemia in a Georgian Population

Mamatsashvili

Svanidze²,

Saralidze³

et al. 2018

IAM

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Aim: The prevalence of hyperuricemia has been increased in recent years. The metabolic syndrome (MS), which consists of multiple interrelated conditions, increases the risk for atherosclerosis, cardiovascular diseases and type 2 diabetes, as well as mortality from cardiovascular diseases and all causes [1]. Several studies have found an association between hyperuricemia and metabolic syndrome, moreover, several authors have suggested that serum uric acid (SUA) levels should be included in the definition of metabolic syndrome, as increased serum uric acid levels are independently associated with a higher risk of cardiovascular mortality. The aim of the present study was to analyze the association of hyperuricemia and metabolic syndrome and its several components in a Georgian population. The study includes 83 patients with MS and hyperuricemia (51 males and 32 females), aged 61±9 years, who have addressed to The First University Clinic of Tbilisi State Medical University from January 2017 to December 2017. All patients had asymptomatic hyperuricemia. 55 patients without MS constituted the control group. Biochemical parameters: glucose, Total-Cholesterol, HDL-cholesterol, LDL-cholesterol, Triglycerides, Creatinine, Uric acid, Creactive protein (CRP) were obtained with routine technique. Hyperuricemia was defined as SUA level ≥7.0 mg/dL in men and ≥6.0mg/dL in women. Waist circumference (cm) was measured and body mass index (BMI) was calculated (kg/m2). Results: The result of our study shows, that patients with MS show higher risk of hyperuricemia than those without MS -7.8 ±2.1 vs 5.9±1.3. Hyperuricemia was associated with a higher risk of presenting all the MS components, except hypertension and HDL. Conclusion: In the present study carried out in a Georgian population, we have found an association between SUA levels and MS, especially with Glucose intolerance, abdominal obesity and hypertriglyceridemia.

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“…Although serum UA is not included in the diagnostic criteria for MetS, epidemiological studies have established a close relationship between elevated serum UA levels and the increasing prevalence of MetS [9,10,19] . Serum UA, a weak acid, may also affect urine pH.…”

Section: Discussionmentioning

confidence: 99%

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

Shimodaira

Okaniwa²,

Nakayama³

2017

Med Princ Pract

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across urine pH categories. Path analysis was used to determine the relationship between MetS and urine pH. Results: Subjects with MetS had significantly lower urine pH (5.9 ± 0.7) than those without MetS (6.0 ± 0.7) ( p < 0.001). Partial correlation analysis showed that systolic and diastolic blood pressure, and triglyceride and fasting plasma glucose levels were negatively correlated with urine pH, while high-density lipoprotein cholesterol was positively correlated with urine pH. Analysis of covariance indicated that urine pH decreased with an increasing number of metabolic abnormalities. Adjusted ORs (95% CI) for the presence of MetS in subjects with urine pH 5.5-6.0 and pH <5.5 were 1.34 (1.04-1.73) and 1.52 (1.09-2.13), respectively (reference: subjects with a urine pH >6.0). Conclusion: The MetS and its components were independently associated with lower urine pH. AbstractObjective: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components, while controlling for covariates. Subjects and Methods: This crosssectional study was conducted on 5,430 Japanese subjects (4,691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of covariance were used for controlling confounding parameters (age, gender, levels of serum uric acid and high-sensitivity C-reactive protein, estimated glomerular filtration rate, and smoking and drinking status). Using multiple logistic regression analyses, adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for MetS incidence were calculated Significance of the Study• In this study, a significant, inverse relationship between urine pH and metabolic syndrome and the number of its components were identified after controlling for confounding factors, including serum uric acid levels. The examination of urine pH could be a practical screening tool for metabolic syndrome.

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Serum uric acid and metabolic syndrome in Taiwanese adults

Cited by 60 publications

References 28 publications

Major Dietary Patterns and Risk of Asymptomatic Hyperuricemia in Chinese Adults

Major Dietary Patterns and Risk of Asymptomatic Hyperuricemia in Chinese Adults

Association of Metabolic Syndrome with Asymptomatic Hyperuricemia in a Georgian Population

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

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