Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing. The PRC-USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology

Li, Y; Stamler, Jeremiah; Xiao, Zhu; Folsom, Aaron R.; Sui, Tao; Zhang, H

doi:10.1093/ije/26.2.288

Cited by 53 publications

(24 citation statements)

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“…Furthermore, SUA is independently related to BMI, serum lipids, particularly TG, and to serum glucose. While some of the relation of SUA to BP is apparently due to the strong relation of BMI to both SUA and BP, a low order significant relation between SUA and BP remains after controlling for BMI (26). In our study, those risk factors were also associated with a higher SUA level.…”

Section: Discussioncontrasting

confidence: 47%

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

et al. 2005

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Objective Several cohort studies have shown a link between serum uric acid (SUA) and subsequent cardiovascular disease. However, such an association did not remain significant after adjusting for concomitant risk factors for atherosclerosis in some studies. Thus, the role of SUA as an independent risk factor remains controversial. We therefore investigated the association between SUA and sclerotic lesions of common carotid atherosclerosis.Patients and Methods We evaluated sclerotic lesions of the common carotid arterial intima-media thickness (IMT) by ultrasonography in 398 men aged 74±8 (range, 60-97) years and 521 women aged 75±8 (range, 60-104) years. To investigate the relation between SUA and various factors, all subjects were divided into three groups based on the tertile of SUA.Results Stepwise multiple linear regression analysis using IMT as an objective variable, adjusted by various risk factors as explanatory variables showed that SUA [B, 0.0099; 95% confidence interval (CI), 0.0022-0.0175] was a significant independent contributing factor along with known risk factors such as age, sex, smoking status, systolic blood pressure, diastolic blood pressure, antihypertensive drug use, HDL-cholesterol, and LDLcholesterol. Multiple logistic regression analysis for carotid IMT as a tertile of SUA and dependent variables showed that the adjusted odds ratio was 1.25 (95% CI, 0.87-1.78) for those in the middle tertile (4.2-5.5 mg/dl), and 1.66 (95% CI, 1.16-2.39) for those in the highest tertile (5.6-14.1 mg/dl) compared to that for subjects in the lowest tertile of SUA levels (0.51-4.1 mg/dl).Conclusion We suggest that SUA is a risk factor or marker for ultrasonographically determined IMT.

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Section: Discussioncontrasting

confidence: 47%

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

et al. 2005

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“…Recent findings show that the occurrence of gout is increasing in China [27], possibly due to changes in dietary habits. The treatment of gout entails the use of several classes of therapeutic agents such as xanthine oxidase inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis

Kong

Zhang

Pan

et al. 2000

CMLS, Cell. Mol. Life Sci.

144

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The methanol extract of the stem of Sinofranchetia inhibited the activity of xanthine oxidase in vitro. Bioassay-guided purification led to the isolation ofliquiritigenin and isoliquiritigenin as the main xanthine oxidase inhibitors. This inhibition of enzyme activity was found to be dose dependent, with an IC50 value of approximately 49.3 microM for liquiritigenin and 55.8 microM for isoliquiritigenin. Lineweaver-Burk transformation of the inhibition data indicated that the inhibition was of a mixed type for both liquiritigenin and isoliquiritigenin. For liquiritigenin, the Ki and K(I) were determined to be 14.0 microM and 151.6 microM, respectively. For isoliquiritigenin, the Ki and K(I) were determined to be 17.4 microM and 81.9 microM, respectively. These results suggest that these natural products could be used to treat conditions where the inhibition of xanthine oxidase is warranted.

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“…Recent epidemiologic data indicated that the incidence of primary gout has increased by 2-fold over the past 20 years (Arromdee et al, 2002). This disease is also rapidly rising in China (Li et al, 1997), due probably to recent changes in dietary habits. Hyperuricemia is a hallmark of gout (Rott and Agudelo, 2003).…”

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confidence: 99%

The Dual Actions of Morin (3,5,7,2′,4′-Pentahydroxyflavone) as a Hypouricemic Agent: Uricosuric Effect and Xanthine Oxidase Inhibitory Activity

Yu¹,

Fong²,

Chen³

2005

J Pharmacol Exp Ther

107

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Hyperuricemia is associated with a number of pathological conditions such as gout. Lowering of elevated uric acid level in the blood could be achieved by xanthine oxidase inhibitors and inhibitors of renal urate reabsorption. Some natural compounds isolated from herbs used in traditional Chinese medicine have been previously demonstrated to possess xanthine oxidase inhibitory activities. In the present investigation, morin (3,5,7,2Ј,4Ј-pentahydroxyflavone), which occurs in the twigs of Morus alba L. documented in traditional Chinese medicinal literature to treat conditions akin to gout, was demonstrated to exert potent inhibitory action on urate uptake in rat renal brushborder membrane vesicles, indicating that this compound acts on the kidney to inhibit urate reabsorption. Lineweaver-Burk transformation of the inhibition kinetics data demonstrated that the inhibition of urate uptake was of a competitive type, with a K i value of 17.4 M. In addition, morin was also demonstrated to be an inhibitor of xanthine oxidase. Lineweaver-Burk analysis of the enzyme kinetics indicated that the mode of inhibition was of a mixed type, with K i and K ies values being 7.9 and 35.1 M, respectively. Using an oxonate-induced hyperuricemic rat model, morin was indeed shown to exhibit an in vivo uricosuric action, which could explain, in part at least, the observed hypouricemic effect of morin in these rats. The potential application of this compound in the treatment of conditions associated with hyperuricemia was discussed.

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Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing. The PRC-USA Collaborative Study in Cardiovascular and Cardiopulmonary Epidemiology

Cited by 53 publications

References 0 publications

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis

The Dual Actions of Morin (3,5,7,2′,4′-Pentahydroxyflavone) as a Hypouricemic Agent: Uricosuric Effect and Xanthine Oxidase Inhibitory Activity

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