Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing

Xiu, Shuangling; Zhang, Zheng; Guan, Shaochen; Zhang, Jin; Ma, Jinghong; Chan, Piu

doi:10.1016/j.neulet.2016.11.013

Cited by 29 publications

(27 citation statements)

References 44 publications

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“…The data for this article were obtained from the Beijing Longitudinal Study of Aging II study, which was initiated in 2009 10. A multistage cluster random sampling method was performed to select a representative community cohort.…”

Section: Methodsmentioning

confidence: 99%

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

Xiu

Zhang

Liao

et al. 2019

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AimThe aim of this study was to investigate whether elderly people with impaired fasting glucose (IFG) or diabetes mellitus (DM) share the common risk factors for cognitive impairment as compared to normal blood glucose population.MethodsThis cross-sectional study assessed 10,039 community-dwelling participants aged ≥ 55 years in Beijing, China. According to the glycemic status, subjects were classified into three groups: normal fasting plasma glucose (NG, n=6399), impaired fasting glucose (IFG, n=873) and DM (n=2626). The Mini-Mental State Examination (MMSE) was applied to evaluate the cognitive function status of the study population. Potential demographic, clinical, and genetic risk factors for cognitive impairment were collected and compared across the three groups. Multivariate logistic regression model was performed to explore the risk factors associated with cognitive impairment.ResultsEducation-modified MMSE scores in the participants with NG, IFG, and DM were 26.91±3.94, 26.67±4.00, and 26.58±4.11, respectively (P=0.0008). In the age- and sex-adjusted comparisons, the MMSE scores in subjects with DM and IFG were significantly lower than that in subjects with normal glucose (P=0.01 and P=0.02, respectively). The logistic regression analysis showed that risk factors only in the NG population were older age, female, apoEε4 carrier, normal or lower uric acid (UA) levels. Hypertension was an independent risk factor only in IFG group, and the history of stroke and depression were the risk factors associated with cognitive impairment only in the DM group.ConclusionSubjects with DM or IFG had a lower performance on the MMSE test compared with subjects who had normal blood glucose. The elderly with diabetes and IFG have some different risk factors for cognitive impairment as compared to those with normal blood glucose.

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Section: Methodsmentioning

confidence: 99%

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

Xiu

Zhang

Liao

et al. 2019

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“…However, several studies have reported results in contrast to our current study. Some cross-sectional studies have suggested that higher uric acid levels are a protective factor for cognitive impairment in the elderly [19,50,51]. Moreover, serum UA levels have been found to be low in subjects with established AD or vascular cognitive impairment [52,53].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, evidence has consistently shown that the level of serum UA is associated with cognitive function, but this relationship remains controversial. Some studies have indicated that the higher level of serum UA is associated with better cognitive performance owing to the antioxidant property of serum UA [18][19][20][21][22][23]. Specifically, a retrospective study including 1374 elderly showed that higher levels of serum UA were related to better cognitive function after controlling for cardiovascular risk factors [18].…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, a retrospective study including 1374 elderly showed that higher levels of serum UA were related to better cognitive function after controlling for cardiovascular risk factors [18]. A large cross-sectional study consisting of 10,039 Chinese community-dwelling participants aged ≥55 years indicated that high serum UA was associated with a decreased risk of cognitive impairment after adjusting for age, sex, lifestyle, relevant diseases and the apolipoprotein E (APOE) ε4 allele [19]. A prospective cohort study found that elevated serum UA predicted a decreased risk of dementia after adjusting for several cardiovascular risk factors among 4618 participants aged ≥55 years and that higher serum UA at baseline predicted better cognitive performance later in life in the absence of cardiovascular risk factors among 1724 participants who remained free of dementia during follow-up [21].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between serum uric acid and cognitive function in patients with chronic heart failure

Niu

Yang

2020

BMC Cardiovasc Disord

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Background: Evidence has shown that serum uric acid (UA) is associated with cognitive function, but this finding remains debatable. Serum UA is commonly elevated in patients with chronic heart failure (CHF), especially in men. However, the relationship between serum UA and cognitive function in CHF populations and stratified by sex are unclear. We aimed to examine whether serum UA was independently associated with cognitive function in CHF populations after controlling for demographic, medical and psychological variables and whether there was a sex difference in the association between serum UA and cognitive function among male and female CHF patients. Methods: One hundred ninety-two hospitalized patients with CHF underwent an assessment of cognitive function using the Montreal Cognitive Assessment (MoCA) and the determination of serum UA. Hyperuricemia was defined as serum UA ≥7 mg/dl in men and ≥ 6 mg/dl in women. Multiple linear hierarchical regression analyses were conducted to examine the independent association between serum UA and cognitive function in CHF populations and stratified by sex. Results: The mean serum UA concentration of participants was 7.3 ± 2.6 mg/dL. The prevalence of hyperuricemia was 54.7% (105 of 192) in CHF patients, 52.9% (64 of 121) in men, and 57.7% (41 of 71) in women. In the total sample, higher serum UA was associated with poorer cognitive function independent of demographic, medical and psychological variables (β = − 0.130, ΔR 2 = 0.014, p = 0.015). In sex-stratified groups, elevated serum UA was independently associated with worse cognitive function in men (β = − 0.247, ΔR 2 = 0.049, p = 0.001) but not in women (β = − 0.005, ΔR 2 = 0.000, p = 0.955). Conclusions: Higher serum UA is independently associated with poorer cognitive function in CHF populations after adjusting for confounding variables. Furthermore, elevated serum UA is independently related to worse performance on cognitive function in men but not in women. More longitudinal studies are needed to examine the association between serum UA and cognitive function in CHF populations and stratified by sex.

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“…The MMSE scale has a sensitivity above 88.3% and a specificity of 87% with a cut-off point of 24 for detecting cognitive impairment in patients with neurodegeneration [20,21]. In this study, cognitive impairment was defined as: a score ≤17 for illiterates; a score ≤20 for primary school graduates (≥6 years of education); and a score ≤24 for junior school graduates or above (≥9 years of education) [22,23].…”

Section: Viewpoints Research Themementioning

confidence: 99%

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Ding¹,

Zhao²,

Wang³

et al. 2020

Journal of Global Health

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Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing

Cited by 29 publications

References 44 publications

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

The relationship between serum uric acid and cognitive function in patients with chronic heart failure

Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

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