Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Ding, Guoyong; Zhao, Xuan; Wang, Youxin; Song, Daiyu; Chen, Dongzhen; Deng, Yang; Xing, Weijia; Dong, Hualei; Zhou, Yong; Dong, Li; Hou, Haifeng

doi:10.7189/jogh.10.010804

Cited by 17 publications

(9 citation statements)

References 57 publications

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“…Kolmogorov-Smirnov tests were used to test the normality of the continuous variables. Continuous variables are presented as the mean with standard deviation and were compared using the independent-sample t test; meanwhile, variables with a skewed distribution are presented as the median [interquartile range ( 22 )]; Categorical variables were compared using the chi‐square test. Spearman correlation was used to explore the separate correlation between GGT, TBIL and inflammatory and immunological indexes.…”

Section: Participants and Methodsmentioning

confidence: 99%

Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women

et al. 2021

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BackgroundSystemic lupus erythematosus (SLE) affects many organs and systems of the human organism, at present, its specific pathogenesis is not completely clear, but inflammation is considered to be an important factor involved in the pathogenesis and progression of SLE. Gamma-glutamyl transpeptidase (GGT) and total bilirubin (TBIL) have different effects on inflammation: GGT has pro-inflammatory effects, on the contrary, TBIL has anti-inflammatory effects. Study has found that GGT and TBIL play opposite roles in metabolic diseases. However, the roles of them in SLE are unknown. Meanwhile, the relationship between GGT and SLE also remains unexplored.MethodWe recruited 341 SLE patients and 332 healthy individuals in Liaocheng People’s Hospital from August 2018 to May 2019. We diagnosed SLE using 2019 revised American College of Rheumatology (ACR) SLE criteria, and modeled the study outcomes using logistic regression to explore the respective relationship between GGT, TBIL and SLE. We also analyzed the interaction of GGT and TBIL in the progression of SLE.ResultsWe found that the levels of CRP, IL-6 and TNF-α in the aggravated group were significantly higher than those in the unaggravated group, the levels of C3 and C4 in the aggravated group were significantly lower than those in the unaggravated group. According to Spearman correlation analysis, GGT is proportional to CRP (rs=0.417) and IL-6 (rs=0.412), inversely proportional to C3 (rs=-0.177) and C4 (rs=0.-132). TBIL was inversely proportional to CRP (rs=-0.328) and TNF(rs=-0.360), and positively proportional to C3 (rs=0.174) and C4 (rs=0.172). In the fully adjusted model, compared to the lowest quartile, the highest quartile of GGT exhibited a positive association with the risk of SLE aggravation (OR=2.99, 95% CI: 1.42–6.31, P<0.001). At the same time, compared to the highest quartile, the quartile lowest of TBIL exhibited a positive association with the risk of SLE aggravation (OR=2.66, 95% CI: 1.27–5.59, P<0.001) in the fully adjusted model. Through interaction analysis, we found that women with high GGT levels had an increased risk of SLE aggravation when they had a low level of TBIL (OR=3.68, 95% CI: 1.51–9.01, for women with Q1 TBIL and Q4 GGT compared to women with Q2-Q4 TBIL and Q1-Q3 GGT, P for interaction <0.001), the combined AUC value (AUCCOMBINED=0.711) of high GGT level and TBIL were higher than their respective values (AUCGGT=0.612, AUCTBIL=0.614).ConclusionWe found that the effects of GGT and TBIL in the progression of SLE are opposite. High GGT level might be a risk factor for SLE aggravation, as GGT levels increased, so did the risk of SLE aggravation. At the same time, we found that low TBIL level might be a risk factor for SLE aggravation. Moreover, high GGT level and low TBIL level had a subadditive effect on the increased risk of SLE aggravation.

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Section: Participants and Methodsmentioning

confidence: 99%

Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women

et al. 2021

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“…With the prescriptions from the ancient classis and the management through the right food structure with specific intake amount and order, the very severe conditions of heart troubles can be handled with just two doses of one prescription for enhancing the innate capability of the spleen and stomach to produce and move the blood, while reducing the heat already accumulated in the chest. For those still at work or in the condition of suboptimal health status (SHS), they have no time to stay in the hospital and doctors have no way to change their unhealthy lifestyles [16,17,18]. On the contrary, it doesn't need to keep anyone in the hospital when the right prescription is given and the medicine is taken at home, which is true for the treatment for all diseases by TCM.…”

Section: The Advantages Of Tcm In Mhmtmentioning

confidence: 99%

The Medical & Health Maintenance Tourism and Ecosystem of Industries around TCM Services

Liu

Zhang

et al. 2021

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Background: Medical and health maintenance tourism (MHMT) is rising fast in our aging society with the largest population in the world. At the very core of its development, medical services are crucial for driving the development of the related industries that can develop into an ecosystem for sustainability. Methods: Through the market analysis, it is made very clear that the diversified demands can only be met by the medical services around TCM with its various advantages, which are proven in the example of the success of Mt. Qingcheng as Tianfu Qingcheng Resort for MHMT. Results: With TCM services as the driving force, the local hospitals, tertiary industry, transportation and logistics, and the R&D of new medicine grow into an ecosystem. Conclusions: The green ecosystem will enable the sustainable development of MHMT.

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“…Accumulating evidences suggests that SHS is associated with mental health disorders [ 13 ], psychosocial stress [ 14 ], cognitive disorders [ 15 ]. Psychosocial or psychological factor(s) is defined as one of the four categories of fundamental factors influencing health, others including chemical, physical and biological factors [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: a cross-sectional study of suboptimal health status

et al. 2020

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Background Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the feasibility of improving health status and preventing diseases according to PPPM concepts in Chinese nurses. Methods A cross-sectional study was conducted with the cluster sampling method among 9793 registered nurses in Foshan city, China. SHS was evaluated with the Suboptimal Health Status Questionnaire-25 (SHSQ-25). Meanwhile, the PS of depression and anxiety were evaluated with Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) self-assessment questionnaires. The relationship between PS and SHS in Chinese nurses was subsequently analyzed. Results Among the 9793 participants, 6107 nurses were included in the final analysis. The prevalence of SHS in the participants was 74.21% (4532/6107) while the symptoms of depression and anxiety were 47.62% (2908/6107) and 24.59% (1502/6107) respectively. The prevalence of SHS in the participants with depression and anxiety was significantly higher than those without the symptoms of depression (83.3% vs 16.7%, P < 0.001) and anxiety (94.2% vs 5.8%, P < 0.0001). The ratio of exercise habit was significantly lower than that of non-exercise habit (68.8% vs 78.4%, P < 0.001) in SHS group. Conclusions There is a high prevalence of SHS and PS in Chinese nurses. PS in Chinese nurses are associated with SHS. Physical exercise is a protective factor for SHS and PS so that the exercise should be strongly recommended as a valuable preventive measure well in the agreement with PPPM philosophy. Along with SDS and SAS, SHSQ-25 should also be highly recommended and applied as a novel predictive/preventive tool for the health measures from the perspectives of PPPM in view of susceptible population and individual screening, the predisposition to chronic disease preventing, personalization of intervention, and the ideal health state restoring.

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Evaluation of the relationship between cognitive impairment and suboptimal health status in a northern Chinese population: a cross-sectional study

Cited by 17 publications

References 57 publications

Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women

Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women

The Medical & Health Maintenance Tourism and Ecosystem of Industries around TCM Services

Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: a cross-sectional study of suboptimal health status

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