Serum unconjugated estriol concentrations before and after the oxytocin challenge test: An index of fetal well-being

London, Robert S.; Vallejos, J.; Baer, Darius; Strummer, Deli; Reynolds, Monica; Goldstein, Phillip J.

doi:10.1016/0002-9378(83)91003-7

American Journal of Obstetrics and Gynecology

1983

DOI: 10.1016/0002-9378(83)91003-7

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Serum unconjugated estriol concentrations before and after the oxytocin challenge test: An index of fetal well-being

Robert S. London

J. Vallejos

Darius Baer

et al.

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Cited by 3 publications

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“…Measurements of urinary oestrogen and of plasma unconjugated and total oestriol (E3) levels are widely used in the assessment of fetoplacental wellbeing. They have been shown to be mainly of value in the diagnosis of intrauterine growth retardation and in the management of the high risk and post-term fetus, particularly when the results are interpreted along with other indices of fetal wellbeing (Allen & Lachelin 1978;Goebelsmann 1979;O'Herlihy & Martin 1980;Khouzami et al 1981;Chard & Klopper 1982;London et al 1983).…”

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confidence: 99%

A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout normal pregnancy

Lachelin

Mcgarrigle

1984

BJOG

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Saliva unconjugated, plasma unconjugated and plasma total oestriol (E3) levels were measured longitudinally, by radioimmunoassay, in 25 normal women from 13 weeks gestation until delivery. The increase in salivary unconjugated oestriol closely paralleled that of plasma unconjugated oestriol and to a lesser extent that of plasma total oestriol. In each patient the percentage value of salivary E3/plasma unconjugated E3 x 100 was virtually constant throughout pregnancy but this percentage varied from one patient to another (mean 14.4%). The overall correlation coefficient (r) for salivary and plasma unconjugated E3 was 0.90. The variability in salivary levels in samples collected at daily, hourly, 15 min and 5 min intervals (12.7, 13.4, 10.1 and 9.3%) was similar to that previously described for plasma unconjugated E3. There was no distinct pattern in diurnal variation. It seems probable that measurement of salivary E3 could adequately replace that of plasma unconjugated E3 in the assessment of fetoplacental function.

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confidence: 99%

A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout normal pregnancy

Lachelin

Mcgarrigle

1984

BJOG

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Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small-for-gestational-age infants

Heazell

Hayes

Whitworth

et al. 2019

Cochrane Database of Systematic Reviews

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Fetal and maternal endocrine responses to reduced uteroplacental blood flow.

Shepherd

Stanczyk

Bethea

et al. 1992

The Journal of Clinical Endocrinology & Metabolism

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In clinical practice, falling or reduced maternal estrogen levels are commonly regarded as indicators of fetal distress. However, experimental studies in primate animal models demonstrate that changes in maternal estradiol concentrations vary in response to reduced uteroplacental blood flow and are elevated during fetal hypoxemic stress, suggesting an increase in fetal adrenal precursor steroids. We studied the effects of graded reductions in maternal distal aortic blood flow (Qda) on the fetal MCR of dehydroepiandrosterone (D; MCR-D), the fetal production rate of D (PR-D), and changes in maternal and fetal plasma concentrations of D, D sulfate, cortisol, androstenedione, estrone (E1), and estradiol (E2) and in fetal plasma ACTH, PRL, and LH. A continuous i.v. infusion of [7-3H]D was administered to fetuses in five pregnant baboons (Papio anubis) at 155-165 days gestation (term, 184 days) for 270 min. A 50% reduction in mean distal aortic blood flow was imposed after 60 min by means of partial occlusion of the aorta with a snare device, which was released at 180 min. Maternal and fetal blood samples were collected at 10-min intervals from 30-60, 120-180, and 240-270 min. Equilibrium concentrations of [3H]D in fetal plasma were determined, and the MCR-D and PR-D were calculated for each of the three levels of Qda corresponding to the control, occlusion, and release intervals. Concentrations of steroid and peptide hormones in maternal and fetal plasma were determined by RIA, and arterial blood pH, pO2, and pCO2 were measured. Control fetal PR-D (mean +/- SE, 4.4 +/- 2.0 mg/day) rose significantly during aortic occlusion accompanied by fetal hypoxemia (11.8 +/- 3.1 mg/day; P less than 0.05) and remained elevated with release of the aortic constriction (13.8 +/- 2.9 mg/day). Changes in fetal MCR-D were variable and not statistically significant. Among the maternal plasma steroids, only E1 and E2 increased significantly, doubling from control values during aortic occlusion and increasing by another 50% after release (P less than 0.05). There was a significant correlation between fetal PR-D and maternal plasma E2 and E1 concentrations (r2 = 0.76 and 0.71, respectively; P less than 0.01). Fetal hypoxemia was associated with dramatic increases in fetal plasma D, D sulfate, androstenedione, E1, and E2. No significant change occurred in fetal plasma cortisol, which tended to decline throughout the study. We observed a dramatic and sustained increase in fetal plasma ACTH during the period of reduced Qda and for 90 min thereafter, but no change in PRL or LH.(ABSTRACT TRUNCATED AT 400 WORDS)

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Serum unconjugated estriol concentrations before and after the oxytocin challenge test: An index of fetal well-being

Cited by 3 publications

References 10 publications

A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout normal pregnancy

A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout normal pregnancy

Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small-for-gestational-age infants

Fetal and maternal endocrine responses to reduced uteroplacental blood flow.

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