Serum type I collagen and N-terminal peptide of type III procollagen in chronic hepatitis

Bilić

et al. 2003

Wien Klin Wochenschr

Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Predictive role of serum procollagen III peptide and Knodell’s index in survival prognosis of patients with hepatitis B virus liver cirrhosis

Bilić

et al. 2003

Wien Klin Wochenschr

“…Several serum markers of liver fibrosis, such as type IV collagen, laminin, and procollagen III peptide, are elevated in the presence of various kinds of chronic liver damage [1][2][3][4][5]. Among these markers, type IV collagen has proved to be an important substance in the formation of the basement membrane-like structure in Disse's spaces in the cirrhotic liver [6,7].…”

mentioning

confidence: 99%

Significance of Serum Type IV Collagen Level of Hepatectomized Patients with Chronic Liver Damage

et al. 2002

Type IV collagen, one of the serum markers for hepatic fibrosis, was measured perioperatively in patients with and without chronic liver damage to investigate whether this parameter changes in response to acute stress to the liver and can predict the surgical risk of hepatic resection. The serum type IV collagen level was significantly elevated in patients with liver cirrhosis. There were significant correlations between serum type IV collagen levels and the indocyanine green clearance test and cholinesterase activity, although the correlation coefficients were not high. The size of the resected hepatic mass was not the primary factor to influence the postoperative serum type IV collagen level. In patients with liver cirrhosis, the postoperative serum type IV collagen level increased significantly compared to that in patients with normal liver or chronic hepatitis. Postoperative liver failure occurred in 0%, 11.6%, and 44.4% of patients with preoperative serum type IV collagen levels of <150, < or = 150 to 300, and > or = 300 ng/ml, respectively. In those with postoperative liver failure, the serum type IV collagen levels were significantly higher both pre- and postoperatively compared to those in patients with uneventful courses. Several preoperative liver function tests indicated that type IV collagen is an independent risk factor for postoperative liver failure. Thus perioperative measurement of the serum type IV collagen levels seemed to be useful for predicting the risk of hepatic resection in patients with chronic liver damage.

“…PCICP is the main component of connective tissue[ 25 ]. The upper limit of normal values is 202 and 170 µg in males and females, respectively[ 26 - 28 ]. It is increased in cirrhosis progression.…”

Section: Biological Approachmentioning

confidence: 99%

Potential role of noninvasive biomarkers during liver fibrosis

Kaur¹,

Goyal²,

Garg³

et al. 2021

WJH

Various types of liver disease exist, such as hepatitis and alcoholic liver disease. These liver diseases can result in scarring of liver tissue, cirrhosis, and finally liver failure. During liver fibrosis, there is an excess and disorganized accumulation of extracellular matrix (ECM) components which cause the loss of normal liver cell functions. For patients with chronic liver disease, fibrosis prediction is an essential part of the assessment and management. To diagnose liver fibrosis, several invasive and noninvasive markers have been proposed. However, the adoption of invasive markers remains limited due to their inherent characteristics and poor patient acceptance rate. In contrast, noninvasive markers can expedite the clinical decision through informed judgment about disease stage and prognosis. These noninvasive markers are classified into two types: Imaging techniques and serum biomarkers. However, the diagnostic values of biomarkers associated with liver fibrosis have also been analyzed. For example, the serum levels of ECM proteins can react to either matrix accumulation or degradation. During virus-host interactions, several regulatory steps take place to control gene expression, such as the change in cellular microRNA expression profiles. MicroRNAs are a class of non-coding RNAs (18-20 long nucleotides) that function by post-transcriptional regulation of gene expression. Although various noninvasive markers have been suggested in recent years, certain limitations have restricted their clinical applications. Understanding the potential of non-invasive biomarkers as a therapeutic option to treat liver fibrosis is still in progress.