Predictive role of serum procollagen III peptide and Knodell’s index in survival prognosis of patients with hepatitis B virus liver cirrhosis

Babić, Žarko; Bilić, Ante; Babić, Dobroslav; Jagić, Vjekoslav; Nikolić, Branko; Sunić, Martina

doi:10.1007/bf03040336

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…[11–13] El-Mezayen et al [11] combined serum IVC and LN levels with liver biochemical indexes to develop a fibrosis discriminant scoring system and found that the scoring system estimated significant liver fibrosis with 79% sensitivity and 88% specificity in patients with chronic hepatitis C. Incorporation of serum levels of PIIINP into conventional assessment approaches, such as the Knodell index, has been found to improve the accuracy of prediction of the survival prognosis in patients with hepatitis B virus liver cirrhosis. [12] In addition, serum HA has also been tested as a biomarker to evaluate the severity of liver fibrosis. [13] …”

Section: Introductionmentioning

confidence: 99%

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

et al. 2017

Medicine

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Noninvasive and convenient tests to assess pulmonary fibrosis and disease progression in interstitial lung diseases (ILDs) are currently unavailable. The extracellular matrix molecules, laminin (LN), type IV collagen (IVC), procollagen III N-terminal peptide (PIIINP), and hyaluronic acid (HA) are involved in ILD development and progression. This study aims to investigate the association of disease progression and serum levels of LN, IVC, PIIINP, and HA in patients with ILD. This retrospective study included 323 patients (162 cases of idiopathic pulmonary fibrosis [IPF] and 161 cases of connective tissue diseases ILD [CTD-ILD]) treated in Shanghai Pulmonary Hospital between January 2013 and January 2015 and 160 healthy controls. Serum LN, IVC, PIIINP, and HA were analyzed by radioimmunoassay. Data of the percentage of forced vital capacity in the prediction value (FVC%pred), the percentage of diffusing capacity of the lung for carbon monoxide in the prediction value (DLCO%pred), high resolution computed tomography (HRCT) score, and patient mortality were collected. Serum LN, IVC, PIIINP, and HA were significantly increased in the patients with IPF or CTD-ILD compared with the healthy controls (all P < .05) and were further elevated in the acute exacerbation cases (all P < .05). Serum LN, IVC, PIIINP, and HA positively correlated with HRCT score and negatively correlated with FVC%pred and DLCO%pred significantly in the patients (all P < .05). The survived patients had significantly lower serum LN, IVC, PIIINP, and HA than the dead patients (all P < .05). Serum levels of LN, IVC, PIIINP, and HA may reflect ILD progression and may be indicators for the severity of ILDs.

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Section: Introductionmentioning

confidence: 99%

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

et al. 2017

Medicine

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“…This study draws parallels from liver fibrosis researches, where ECM serum levels, alongside liver biochemistry markers, have facilitated pulmonary fibrosis assessment and prognosis ( El-Mezayen et al, 2015 ; Babic et al, 2003 ; Neuman et al, 2016 ). By analyzing serum levels of LN, IV COL, PIIINP, and HA in PC19-PF patients against pulmonary function tests and high-resolution computed tomography (HRCT) scores, this research seeks to elucidate their relationship with disease severity and survival prognosis in PC19-PF.…”

Section: Introductionmentioning

confidence: 99%

“…In the past, the serum levels of four ECM molecules have been tested as biological markers for assessing liver fibrosis and predicting the prognosis of patients with liver diseases ( El-Mezayen et al, 2015 ; Babic et al, 2003 ; Neuman et al, 2016 ). Additionally, patients with pulmonary function deterioration and radiographic progression exhibited higher PIIINP and HA levels than those with stable disease ( Bjermer et al, 1989 ).…”

Section: Introductionmentioning

confidence: 99%

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

Yu,

Yin,

Lei

et al. 2024

Front. Cell Dev. Biol.

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COVID-19 patients often suffer from post-COVID-19 acute sequelae (PASC). Pulmonary fibrosis has the most significant long-term impact on the respiratory health of patients, known as post-COVID-19 pulmonary fibrosis (PC19-PF). PC19-PF can be caused by acute respiratory distress syndrome (ARDS) or COVID-19-induced pneumonia. Individuals who experience COVID-19 pneumonia symptoms (including cough, shortness of breath, dyspnea on exertion, and desaturation) for at least 12 weeks after diagnosis, almost all develop PC19-PF. Extracellular matrix molecules: laminin (LN), type IV collagen (IV Col), procollagen III N-terminal peptide (PIIINP), and hyaluronic acid (HA) are involved in the development and progression of PC19-PF. This study aimed to investigate the relationship between the progression of PC19-PF and serum levels of laminin, IV COL, PIIINP, and hyaluronic acid. This retrospective study included 162 PC19-PF patients treated and 160 healthy controls who received treatment at Shenzhen Longgang District Third People’s Hospital, Hebei PetroChina Central Hospital and Changzhi People’s Hospital from January 2021 to December 2023. Serum levels of LN, IV COL, PIIINP, and HA were detected by chemiluminescence immunoassay using commercial kits. Predicted forced vital capacity percentage (FVC% pred), predicted carbon monoxide lung diffusion capacity percentage (DLCO% pred), high-resolution computed tomography (HRCT) scores were assessed, and patient mortality was compared with healthy controls. Serum levels of LN, IV Col, PIIINP, and HA were significantly higher in PC19-PF or CTD-ILD patients than in healthy controls (all p < 0.05), and they were further elevated in acute exacerbation cases (all p < 0.01). In patients, HA was positively associated with HRCT scores and negatively associated with FVC% pred and DLCO% pred (all p < 0.05). Serum levels of LN, IV COL, PIIINP, and HA were significantly lower in surviving patients than in those who deceased (all p > 0.05). Serum levels of LN, IV C, PIIINP, and HA may affect the progression of PC19-PF and may serve as indicators of PC19-PF severity.

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Serum analyses for protein, albumin and IL-1-RA serve as reliable predictors for seroma formation after incisional hernia repair

Klink

Binnebösel

Lucas

et al. 2010

Hernia

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Predictive role of serum procollagen III peptide and Knodell’s index in survival prognosis of patients with hepatitis B virus liver cirrhosis

Abstract: Combining PIIIP and KI with other prognostic parameters is useful in achieving a better precision of survival prognosis in patients with HBV liver cirrhosis.

Cited by 3 publications

References 27 publications

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

Serum analyses for protein, albumin and IL-1-RA serve as reliable predictors for seroma formation after incisional hernia repair

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