Serum tumor necrosis factor‐α, interleukin‐1β, interleukin‐6, and interleukin‐17 relate to anxiety and depression risks to some extent in non‐small cell lung cancer survivor

Liu, Meifang; Yao, Li; Liu, Xuesong

doi:10.1111/crj.13457

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…Twelve studies were in the survivorship setting with 9 studies involving patients with breast cancer, [46][47][48][49][50][51][52][53][54] in addition to other studies of testicular, hepatobiliary, and nonsmall cell lung cancers. 23,55,56 Seven of 12 studies (58%)…”

Section: Survivorshipmentioning

confidence: 99%

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

McFarland

Doherty

Atkinson

et al. 2022

Cancer

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Background Depressive symptoms in patients with cancer are associated with poor quality of life and decreased survival. Although inflammation is reliably associated with depression in otherwise healthy individuals, the association in patients with cancer remains unclear. Given the high prevalence of cancer‐related inflammation, the authors aimed to establish the relationship between inflammation and depression in cancer patients based on extant literature. Methods A systematic review and meta‐analysis was performed using Preferred Reporting Items for Systematic Reviews and Meta‐Analyses 2020 guidelines and registered under Prospero ID CRD42021226743. Three databases were searched including PubMed, the Cochrane Library, and PsycINFO using the following criteria for inclusion: 1) measurement of a peripheral inflammatory marker, 2) use of a validated tool/scale to measure depression, and 3) a cancer diagnosis. Risk of publication bias was assessed by Funnel plot and Egger test. Results Seventy‐three studies were included in the systematic review and 54 studies (n = 5017) were included in meta‐analyses. Associations with depressive symptoms were significant for peripheral blood interleukin (IL)‐6 (standardized mean difference [SMD] = 0.59; 95% confidence interval [CI], 0.35‐0.82), I2 = 57.9%; tumor necrosis factor (TNF) (SMD = 0.73; 95% CI, 0.35‐1.11), I2 = 74.1%; and C‐reactive protein (CRP) (SMD = 0.57; 95% CI, 0.27‐0.87), I2 = 0%. IL‐5, IL‐13, albumin, and neutrophil‐to‐lymphocyte ratio were associated with depressive symptoms but based on fewer studies. Most cancer settings were represented; the number of studies per inflammatory marker varied from 1 to 52. Conclusions Although peripheral inflammatory markers were unevenly studied, the most studied markers (IL‐6, TNF, and CRP) were associated with depressive symptoms in cancer patients and may be useful for management of depressive symptoms in the cancer setting. Lay Summary Peripheral blood inflammatory markers (IL‐6, TNF, and CRP) were associated with depressive symptoms in various cancer settings. Although further studies are warranted, these findings may help identify and manage depressive symptoms in patients with cancer.

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Section: Survivorshipmentioning

confidence: 99%

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

McFarland

Doherty

Atkinson

et al. 2022

Cancer

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“…Regarding cognitive impairment, a study claims that increases in Th17 and interleukin (IL)-17A reduces nitric oxide production, thereby facilitating cognitive dysfunction in mice fed with excess dietary salt (15). Clinically, the relationship between Th-cell-secreted cytokines and anxiety, depression, and cognitive impairment in cancer patients has also been revealed by several previous studies (17,18). For instance, elevated tumor necrosis factor-α and IL-17 indicate enhanced anxiety and depression risks in non-small cell lung cancer (NSCLC) patients (17).…”

Section: Introductionmentioning

confidence: 73%

“…Clinically, the relationship between Th-cell-secreted cytokines and anxiety, depression, and cognitive impairment in cancer patients has also been revealed by several previous studies (17,18). For instance, elevated tumor necrosis factor-α and IL-17 indicate enhanced anxiety and depression risks in non-small cell lung cancer (NSCLC) patients (17). Moreover, IL-4 is increased in breast cancer patients with cognitive impairment (18).…”

Section: Introductionmentioning

confidence: 73%

Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Zhou

2022

Front. Surg.

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ObjectiveT helper (Th) cells modulate the stress response, oxidative stress, and neuroinflammation to mediate anxiety, depression, and cognitive impairment. This study intended to explore the association between Th cells and anxiety, depression, and cognitive impairment in elderly gastric cancer patients.MethodsTotally, 176 elderly gastric cancer patients were enrolled in this study. Peripheral blood samples were collected. Th1, Th2, and Th17 cells were detected by flow cytometry; their corresponding cytokines were examined by ELISA. The Hospital Anxiety and Depression Scale (HADS) and Mini-Mental State Examination (MMSE) were assessed.ResultsIn total, 42.0%, 33.0%, and 19.9% of elderly gastric cancer patients presented anxiety, depression, and cognitive impairment, respectively. Th1 (P = 0.016), Th17 (P = 0.009), and IL-17A (P = 0.001) were positively associated with the HADS-A score. Th17 (P = 0.003) and IL-17A (P = 0.009) levels were increased in patients with anxiety compared with those without anxiety. Concurrently, a positive association was observed for Th1 (P = 0.027), Th17 (P = 0.014), and IFN-γ (P = 0.049) with the HADS-D score. Th1 (P = 0.017) and Th17 (P = 0.049) levels were increased in patients with depression than in those without depression. Moreover, Th1 (P = 0.003), Th17 (P < 0.001), IFN-γ (P = 0.014), and IL-17A (P < 0.001) were inversely related to MMSE scores, but only Th17 (P < 0.001) and IL-17A (P < 0.001) were increased in patients with cognitive impairment compared with those without cognitive impairment.ConclusionTh1 and Th17 cells reflect anxiety, depression, and cognitive impairment risk to a certain extent in elderly gastric cancer patients, implying their involvement in the pathology of the abovementioned psychological and cognitive issues. However, further validation is needed.

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“…The abnormal differentiation of T cells plays a crucial clinical role in anxiety and depression by dysregulating the immune system 11–15 . For instance, the T‐helper 1 (Th1)/Th2 cells ratio is elevated in people with depression 13 ; moreover, it also has been reported that Th17 cells are increased in people with depression 16 ; furthermore, another interesting study also presents that Th17 cell‐secreted cytokine (interleukin‐17 [IL‐17]) are positively correlated with the severity of anxiety and depression among lung cancer survivors 15 . Notably, accumulating studies have shown that Th1, Th2, and Th17 cells are abnormally regulated during the postpartum period 17,18 .…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15] For instance, the T-helper 1 (Th1)/Th2 cells ratio is elevated in people with depression 13 ; moreover, it also has been reported that Th17 cells are increased in people with depression 16 ; furthermore, another interesting study also presents that Th17 cell-secreted cytokine (interleukin-17 ) are positively correlated with the severity of anxiety and depression among lung cancer survivors. 15 Notably, accumulating studies have shown that Th1, Th2, and Th17 cells are abnormally regulated during the postpartum period. 17,18 Taken together, we deduced that Th1, Th2, and Th17 might play an important clinical role in PPD and PPA, while related information is scarce.…”

mentioning

confidence: 99%

Blood T‐helper 17 cells and interleukin‐17A correlate with the elevated risk of postpartum depression and anxiety

Min

Ying

2022

Clinical Laboratory Analysis

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The transition of motherhood is a challenge for women, which results in not only a physical burden but also mental disorders. [1][2][3][4] Postpartum depression (PPD) and postpartum anxiety (PPA) are common psychological problems that occur in up to approximately 20% of women, which result in detrimental effects on postpartum women 5,6 ; the common symptoms include insomnia, mood swings, loss of appetite, irritability, and even thoughts of self-harm and suicide. 7,8 In addition, PPD and PPA also have an adverse effect on the neurodevelopment of children, subsequently resulting in physical and psychological problems among children of women with PPD and

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Serum tumor necrosis factor‐α, interleukin‐1β, interleukin‐6, and interleukin‐17 relate to anxiety and depression risks to some extent in non‐small cell lung cancer survivor

Cited by 13 publications

References 30 publications

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

Cancer‐related inflammation and depressive symptoms: Systematic review and meta‐analysis

Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Blood T‐helper 17 cells and interleukin‐17A correlate with the elevated risk of postpartum depression and anxiety

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