Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Zhou, Yanxia; Yu, Ke

doi:10.3389/fsurg.2022.996680

Cited by 14 publications

(10 citation statements)

References 39 publications

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“…Immune checkpoint analysis demonstrated high expression of the most relevant immune checkpoints in the high‐risk group, suggesting that the immune microenvironment in patients with high‐risk gastric cancer was in a suppressed state [33]. These findings emphasize the complexity of the immune microenvironment in gastric cancer and highlight the interplay between different immune cell types and signaling pathways that regulate tumor progression [34]. In summary, mast and Th2 cells play a crucial role in influencing the tumor microenvironment and regulating gastric cancer progression.…”

Section: Discussionmentioning

confidence: 99%

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

Sun,

Ning,

Jia

et al. 2024

Quant. Biol.

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To investigate the impact of hyperglycemia on the prognosis of patients with gastric cancer and identify key molecules associated with high glucose levels in gastric cancer development, RNA sequencing data and clinical features of gastric cancer patients were obtained from The Cancer Genome Atlas (TCGA) database. High glucose‐related genes strongly associated with gastric cancer were identified using weighted gene co‐expression network and differential analyses. A gastric cancer prognosis signature was constructed based on these genes and patients were categorized into high‐ and low‐risk groups. The immune statuses of the two patient groups were compared. ATP citrate lyase (ACLY), a gene significantly related to the prognosis, was found to be upregulated upon high‐glucose stimulation. Immunohistochemistry and molecular analyses confirmed high ACLY expression in gastric cancer tissues and cells. Gene Set Enrichment Analysis (GSEA) revealed the involvement of ACLY in cell cycle and DNA replication processes. Inhibition of ACLY affected the proliferation and migration of gastric cancer cells induced by high glucose levels. These findings suggest that ACLY, as a high glucose‐related gene, plays a critical role in gastric cancer progression.

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Section: Discussionmentioning

confidence: 99%

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

Sun,

Ning,

Jia

et al. 2024

Quant. Biol.

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“…Th cells have been shown to reflect cognition impairment in some studies ( 25 - 27 ). For example, one study indicates that Th17 cells can estimate the progression of cognition impairment in stroke patients ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Serum autophagy-related gene 5 level in stroke patients: correlation with CD4+ T cells and cognition impairment during a 3-year follow-up

Qu,

Wu,

Zhang

et al. 2024

Braz J Med Biol Res

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Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4 + T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4 + T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients. Serum ATG5 was also measured in 50 healthy controls (HCs). Serum ATG5 was elevated in stroke patients compared to HCs (P<0.001) and was positively correlated to Th2 cells (P=0.022), Th17 cells (P<0.001), and Th17/Treg ratio (P<0.001) in stroke patients but not correlated with Th1 cells, Th1/Th2 ratio, or Treg cells (all P>0.050). Serum ATG5 (P=0.037), Th1 cells (P=0.022), Th17 cells (P=0.002), and Th17/Treg ratio (P=0.018) were elevated in stroke patients with MMSE score-identified cognition impairment vs those without cognition impairment, whereas Th2 cells, Th1/Th2 ratio, and Treg cells were not different between them (all P>0.050). Importantly, serum ATG5 was negatively linked with MMSE score at enrollment (P=0.004), Y1 (P=0.002), Y2 (P=0.014), and Y3 (P=0.001); moreover, it was positively related to 2-year (P=0.024) and 3-year (P=0.012) MMSE score decline in stroke patients. Serum ATG5 was positively correlated with Th2 and Th17 cells and estimated cognitive function decline in stroke patients.

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“…T helper (Th) cells modulate the stress response, oxidative stress, and neuroinflammation, potentially participating in the pathogenesis of anxiety, depression, and cognitive impairment. Th1 ( P = 0.017) and Th17 ( P = 0.049) levels were found to be elevated in patients with depression compared to those without depression[ 13 ].…”

Section: Role Of Depression In Gastric Cancer Developmentmentioning

confidence: 99%

Double role of depression in gastric cancer: As a causative factor and as consequence

Christodoulidis,

Konstantinos-Eleftherios,

Marina-Nektaria

2024

World J Gastroenterol

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In this editorial we comment on the article “Hotspots and frontiers of the relationship between gastric cancer and depression: A bibliometric study”. Gastric cancer (GC) is a common malignancy in the digestive system with increased mortality and morbidity rates globally. Standard treatments, such as gastrectomy, negatively impact patients' quality of life and beyond the physical strain, GC patients face psychological challenges, including anxiety and depression. The prevalence of depression can be as high as 57%, among gastrointestinal cancer patients. Due to the advancements in treatment effectiveness and increased 5-year overall survival rates, attention has shifted to managing psychological effects. However, the significance of managing the depression doesn’t lie solely in the need for a better psychological status. Depression leads to chronic stress activating the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, leading release of catecholamines inducing tumor proliferation, migration, and metastasis, contributing to GC progression. The dysregulation of neurotransmitters and the involvement of various signaling pathways underscore the complex interplay between depression and GC. Comprehensive strategies are required to address the psychological aspects of GC, including region-specific interventions and increased monitoring for depression. Understanding the intricate relationship between depression and GC progression is essential for developing effective therapeutic strategies and improving overall outcomes for patients facing this complex disease. In this Editorial we delve into double role of depression in the pathogenesis of GC and as a complication of it.

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Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Cited by 14 publications

References 39 publications

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

Serum autophagy-related gene 5 level in stroke patients: correlation with CD4+ T cells and cognition impairment during a 3-year follow-up

Double role of depression in gastric cancer: As a causative factor and as consequence

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