Serum transferrin receptor levels in Friedreich’s and other degenerative ataxias

The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study

“…A constant relationship has been reported between total TfR and the concentration of sTfR. Thus, the concentration of sTfR is an indirect measure of total TfR [13].…”

Olfactory dysfunction in degenerative ataxias

“…19 One group consisted of the 23 FRDA patients. This group contained 11 men and 12 women (mean (SD) age: 20.46 (12.78) and 35.92 (13.15) years, respectively).…”

Recombinant human erythropoietin: effects on frataxin expression in vitro

“…Clinically there is an intramitochondrial iron accumulation in heart, liver, nervous system and spleen of FRDA‐patients, as well as a reduction of mitochondrial DNA, the FeS cluster‐containing subunits of the mitochondrial electron transport chain (complex I–III) and of the enzyme aconitase [9,10]. The presence of increased levels of soluble transferrin receptor as indicator for cytosolic iron deficiency is controversial [11–13] but in general FRDA patients have normal serum iron and ferritin concentrations [14].…”