Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease

Impaired Systemic Iron Homeostasis and Parkinson's Disease

“…Few studies partly explain such variations. In study by Hedge et al [10] serum iron levels showed decreasing trend with the severity of PD and found 14 % fall in iron concentration in early PD as compared to 30 % in sever PD as compared to controls. Furthermore, Pichler et al [4] demonstrated protective role played by increased serum iron levels in PD suggesting that with every 10µg/dl increase in iron in serum, there is 3 % decrease in risk of PD.…”

Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron

“…2B). These metals are essential for humans and other mammals (3,42). AlCl 3 (500 nM) also inhibited NEIL1 and NEIL2, in the order, CuCl 2 Ͼ FeCl 3 Ͼ FeSO 4 Ͼ AlCl 3 , at equimolar level, whereas MgCl 2 and ZnCl 2 did not affect the activity.…”

Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease

“…On the one hand, element-to-element ratios can provide additional information about metal homeostasis in the organism, given that it has been demonstrated that there is a complex interdependency between the levels of elements in living systems in order to maintain a proper equilibrium [89]. Thus, the effect of changes in a single element concentration could be not restricted to this element alone, but the total element distribution pattern in the system could be affected, as previously described in other works dealing with Parkinson's disease [90], bipolar mood disorders [91] or prostatic cancer [92]. On the other hand, interfraction correlations can also be computed in order to investigate possible imbalances in metabolism of single elements regarding their distribution across different species (i.e., HMM and LMM).…”