Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study

Cui, Renzhe; Moriyama, Yuri; Koike, Kazuko; Date, Chigusa; Kikuchi, Shogo; Tamakoshi, Akiko; Iso, Hiroyasu

doi:10.1016/j.atherosclerosis.2007.09.029

Cited by 52 publications

(53 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Through the initial literature search, a total of 960 potentially relevant publications were identified. After screening the abstracts or titles and reviewing the full texts, 12 studies (Stehouwer et al, 1998;Kark et al, 1999;Hoogeveen et al, 2000;Vollset et al, 2001;Blacher et al, 2002;de Bree et al, 2003;Gonzalez et al, 2007;Cui et al, 2008;Dangour et al, 2008;Swart et al, 2012;Waśkiewicz et al, 2012;Wong et al, 2012) met our inclusion criteria.…”

Section: Literature Searchmentioning

confidence: 99%

“…The prevalence estimates of hyperhomocysteinemia (>14 mmol/L) vary between 5% and 30% in the general population (Selhub et al, 1993;Nygård et al, 1995). Some epidemiologic studies (Hoogeveen et al, 2000;Vollset et al, 2001;Blacher et al, 2002;Gonzalez et al, 2007;Cui et al, 2008;Dangour et al, 2008;Waśkiewicz et al, 2012;Wong et al, 2012) but not all (Stehouwer et al, 1998;Kark et al, 1999;de Bree et al, 2003;Swart et al, 2012) indicated that the elevated Hcy represents a risk factor for total death, CHD death, or cardiovascular mortality in the general population; additionally, this incremental increase in risk was pronounced in high risk subjects (Nygård et al, 1997;Zylberstein et al, 2004;Rossi et al, 2006;Naess et al, 2013). Furthermore, two conducted studies (Bostom et al, 1999;Colon Lopez et al, 2008) were difficult to compare because the Hcy cut-off values varied.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Peng

Man

et al. 2015

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: To investigate whether elevated homocysteine levels were a predictor of subsequent coronary heart disease (CHD) mortality, cardiovascular mortality or all-cause mortality in the general population by a metaanalysis. Methods: In a systematic search conducted in the databases of PubMed and Embase prior to October 2013, we identified relevant prospective observational studies evaluating the association between baseline homocysteine levels and CHD mortality, cardiovascular or all-cause mortality in the general population. Pooled adjust risk ratio (RR) and corresponding 95% confidence interval (CI) were calculated separately for categorical risk estimates and continuous risk estimates. Results: Twelve studies with 23 623 subjects were included in the meta-analysis. Comparing the highest to lowest homocysteine level categories, CHD mortality increased by 66% (RR 1.66; 95% CI 1.12-2.47; P=0.012), cardiovascular mortality increased by 68% (RR 1.68; 95% CI 1.04-2.70; P=0.033), and all-cause mortality increased by 93% (RR 1.93; 95% CI 1.54-2.43; P<0.001). Moreover, for each 5 μmol/L homocysteine increment, the pooled RR was 1.52 (95% CI 1.26-1.84; P<0.001) for CHD mortality, 1.32 (95% CI 1.08-1.61; P=0.006) for cardiovascular mortality, and 1.27 (95% CI 1.03-1.55; P=0.023) for all-cause mortality. Conclusions: Elevated homocysteine levels are an independent predictor for subsequent cardiovascular mortality or all-cause mortality, and the risks were more pronounced among elderly persons.

show abstract

Section: Literature Searchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Peng

Man

et al. 2015

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…Similarly, in Japan, plasma homocysteine seems to be an independent risk factor for atherosclerotic cardiovascular disease (13). Additionally, a nested case-control study as part of the Japan Collaborative Cohort (JACC) Study confirmed that high serum homocysteine levels were associated with increased mortality from ischemic stroke, CAD and total cardiovascular disease among Japanese individuals (14). In China, the prevalence of HHcy is high, reaching 27.5%, which is similar to the incidence reported in Brazil and Lebanon, but higher than the incidence reported in Switzerland, Costa Rica, and Korea, and lower than the incidence reported in Iran, Algeria, and coastal West Africa (15).…”

Section: Discussionmentioning

confidence: 86%

Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

Ren

Zhang

et al. 2016

Intern. Med.

View full text Add to dashboard Cite

Acute myocardial infarction, hyperhomocysteinemia and pulmonary tuberculosis (PTB) are rare in individuals under the age of 30 years. We herein report the case of a 27-year-old man who presented with intermittent chest pain, elevated homosysteine level, and PTB. The patient was treated successfully with a combination of medications and percutaneous coronary intervention. This uncommon case highlights that homocysteine, folate and B vitamins levels should be regularly evaluated, and that chest X-rays or thoracic computed tomography should be ordered routinely to exclude PTB in patients under the age of 30 years who present acute myocardial infarction and lack the traditional risk factors.

show abstract

“…В настоящее время показано, что повышенный уровень ГЦ связан со вторичными сосудистыми событиями и повы-шенной смертностью после инсульта [58,59]. По данным Shi Z. с соавт.…”

unclassified

“…R. Cui с соавт. [59] также сообщили, что у пациентов с самым высоким квартилем ГГЦ значительно повышен риск смертности при ИИ (ОР 4,35, 95% ДИ, 1,12-16,9) по сравне-нию с пациентами с нижнем квартилем.…”

unclassified

Hyperhomocysteinemia and Ischemic Stroke

Пизова¹,

Пизов²

2017

Med. sov.

View full text Add to dashboard Cite

Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study

Cited by 52 publications

References 28 publications

Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

Hyperhomocysteinemia and Ischemic Stroke

Contact Info

Product

Resources

About