Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

Ren, Manyi; Zhang, Chunsheng; Zhang, Xiaojuan; Zhong, Jian

doi:10.2169/internalmedicine.55.4565

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Among these may be drug abuse, congenital coronary abnormalities, coronary spasm, trauma, systemic vasculitis, and hematologic disease [1]. Acute myopericarditis, one of the myocardial involvements in young adults, manifests itself with chest pain, increased cardiac biomarkers, and ST-segment elevation, ST-T changes in electrocardiography [2–4].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of myocardial involvement in acute myopericarditis in young adults

Sarıçam

Saglam

Hazırolan

2017

BMC Cardiovasc Disord

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BackgroundMyocardial involvement in young adults has various causes. Acute myopericarditis is one of the myocardial involvements in young adults. It is easy to confuse with acute ST-elevation myocardial infarction because of the electrocardiographic features. This study aims to investigate a number of imaging techniques and clinical features for acute myopericarditis in young adults (<30 years of age).MethodsThis retrospective study included 147 patients selected from the 2147 patients at the age of <30 with acute chest pain admitted into emergency service between 2010 and 2016. Of 147 patients, 77 patients were diagnosed with acute myopericarditis (group I) (between 18 and 30 aged) and 70 patients had ST-elevation myocardial infarction (group II). The echocardiographic pictures and information of the patients in both groups were rechecked in terms of impaired segmental wall-motion abnormalities, pericardial effusion, and additional features.ResultsThe patients in group I had focal echobright, which was defined as myocardial brightness in the left ventricle regions, especially in posterior and lateral wall. Focal echobright was observed in the 75 of 77 cases of acute myopericarditis in transthoracic echocardiogram. This sign was confirmed by cardiac magnetic resonance imaging. Focal echobright sensitivity was 95%; its specificity was 93%; its predictive was 95.2%. Pericardial effusion (83%) was observed in group I behind posterior wall. Its specificity was 81%; its sensitivity was 65%; predictivity was 73%.ConclusionsPericardial effusion and myocardial focal echobright in echocardiography can be quite sensitive indicators for acute myopericarditis in young adults.

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Section: Introductionmentioning

confidence: 99%

Clinical evaluation of myocardial involvement in acute myopericarditis in young adults

Sarıçam

Saglam

Hazırolan

2017

BMC Cardiovasc Disord

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“…Antitubercular therapy is associated with homocysteinemia [ 12 , 60 , 61 ]. Proteins involved in homocysteine metabolism were affected by antitubercular therapy in our analysis ( Supplementary Table S10 ).…”

Section: Resultsmentioning

confidence: 99%

“…Patients with tuberculosis are at an increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), and ischemic stroke [ 76 , 77 , 78 ], and antitubercular therapy may increase these risks, in addition to increased myocardial infarction risk [ 11 , 12 , 13 , 60 ]. Additionally, antitubercular therapy may cause homocysteinemia, which increases coagulability [ 12 , 60 , 61 ]. We found decreased cystathionine β-synthase in all treatment groups in an hPXR -independent manner.…”

Section: Discussionmentioning

confidence: 99%

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid

Brewer

Kodali

et al. 2020

Cells

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Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of hPXR-mediated hepatotoxicity and the systemic toxicity of antitubercular drugs. The antitubercular drug isoniazid plays a role in such pathologic states as acute intermittent porphyria, anemia, hepatotoxicity, hypercoagulable states (deep vein thrombosis, pulmonary embolism, or ischemic stroke), pellagra (vitamin B3 deficiency), peripheral neuropathy, and vitamin B6 deficiency. However, the mechanisms by which isoniazid administration leads to these states are unclear. To elucidate the mechanism of rifampicin- and isoniazid-induced liver and systemic injury, we performed tandem mass tag mass spectrometry-based proteomic screening of mPxr–/– and hPXR mice treated with combinations of rifampicin and isoniazid. Proteomic profiling analysis suggested that the hPXR liver proteome is affected by antitubercular therapy to disrupt [Fe–S] cluster assembly machinery, [2Fe–2S] cluster-containing proteins, cytochrome P450 enzymes, heme biosynthesis, homocysteine catabolism, oxidative stress responses, vitamin B3 metabolism, and vitamin B6 metabolism. These novel findings provide insight into the etiology of some of these processes and potential targets for subsequent investigations. Data are available via ProteomeXchange with identifier PXD019505.

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Inducible nitric oxide synthase: Good or bad?

Lind

Hayes

Čaprnda

et al. 2017

Biomedicine & Pharmacotherapy

172

116

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Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

Cited by 4 publications

References 43 publications

Clinical evaluation of myocardial involvement in acute myopericarditis in young adults

Clinical evaluation of myocardial involvement in acute myopericarditis in young adults

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid

Inducible nitric oxide synthase: Good or bad?

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