The present study describes the case of a 39-year-old man who had acute retrosternal pain, history of upper tract infection and low-grade fever 3 days prior to presentation, elevated cardiac markers and electrocardiographic ST-T changes, which led to an original suspicion of acute myocarditis. The patient underwent coronary angiography after 36 hours to rule out coronary artery disease, which revealed normal coronary arteries. Finally, the diagnosis of viral myocarditis was confirmed on consideration of his normal coronary angiography, fever, history of upper tract infection and other auxiliary examination results obtained in the following days, which were supportive of the diagnosis. The patient was managed using NSAID, colchicine, betablocker and angiotensin converting enzymes inhibitors and was discharged 4 days later. Viral myocarditis is a common disease with a variable natural history. It remains challenging for doctors to differentiate between acute myocarditis and myocardial infarction, particularly in the early stages. A diagnosis of myocarditis should be made on the basis of synthetic evaluation of the evidence, including medical history, clinical presentation and results of the available auxiliary tests, in order to provide guidelines for treatment.A series of investigations were subsequently performed in the ER. The results of the cardiac enzyme tests disclosed that the troponin I (TnI) level was significantly elevated, up to 583.2 pg/ml and CPK 523 IU/L and CPK-MB 17.47 ng/ml. Of note were the signs of ST-segment elevations in leads V2, V3 and V4 on the electrocardiogram (ECG) (Figure 1). A chest X-ray showed a normal heart size and mild markings in the lungs, with no clear indication of substantive lesion. An echocardiogram showed that the patient's heart functioned normally with an ejection fraction of