Serum total antioxidant capacity in patients with multiple sclerosis

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). It is characterized by loss of myelin, the fatty tissue that surrounds and protects nerve fibres allowing them to conduct electrical impulses. Recent data indicate that oxidative stress (OS) plays a major role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to estimate level of serum total antioxidative capacity in patients with multiple sclerosis. Our cross-sectional study included 33 patients with MS and 24 age and sex matched control subjects. All our patients had a Poser criteria for definite diagnostic categories of multiple sclerosis. Serum total antioxidant capacity (TAC) was measured by quantitative colorimetric determination, using Total antioxidant Capacity-QuantiCromAntioxidant Assay Kit (BioAssay systems, USA; DTAC-100). Mean serum TAC in multiple sclerosis group of patients was 119.2 mM Trolox equivalents and was significantly lower (p<0.001) compared to the control group of subjects (167.1 mM Trolox equivalents). Our results showed that oxidative stress plays an important role in pathogenesis of multiple sclerosis. This finding, also, suggests the importance of antioxidants in diet and therapy of MS patients.

Peripheral oxidative stress in relapsing–remitting multiple sclerosis

“…In this line, similar findings are reported in other studies highlighting the presence of oxidative damage both in blood and nerve tissue samples from patients with MS and in experimental autoimmune encephalitis (EAE) models [18][19][20][21][22].…”

Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients

“…ICU patients are at risk for oxidative damage and, even if they have regular administration of a full dose of recommended vitamin supplementation [33], they present TAC values lower than reported in the literature [34]. As observed in other diseases [35], melatonin seems to be effective in increasing the protection against the total antioxidant damage, by normalizing TAC values. The association between TAC and circulating melatonin suggests that only pharmacological levels influence antioxidant values in a significant manner.…”

Association of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism with Multiple Sclerosis in Turkish Patients

“…Excess reactive oxygen species cause damage at the level of cellular components such as lipids, nucleic acids, and proteins, resulting in cell death. 26 …”