Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis

Wang, Chenyang; Zhao, Liang; Hong, Yupu; Mei, Fangchao; Zhou, Yu; Shi, Qiao; W, Guo; Deng, Wen-feng; Chen, Chen; Yu, Jie-Ping; Wang, Weixing

doi:10.1016/j.bbrc.2018.09.180

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Studies have demonstrated that multiple indicators play crucial roles in detecting patients at risk for SAP and the development of complications. These indicators include serum amylase (AMY) [8], lipase (LIP) [9], low serum ionized calcium (Ca 2+ ) [10], high-sensitivity C-reactive protein (hsCRP) [11], neutrophil-lymphocyte ratio (NLR) [12,13], and BMI [14][15][16]. However, to the best of our knowledge, the changes in these clinic parameters in patients with HTGP have not been previously reported.…”

Section: Introductionmentioning

confidence: 99%

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Jin

et al. 2019

Med Sci Monit

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Background To investigate the clinical characteristics of hypertriglyceridemia pancreatitis (HTGP) and evaluate the correlative risk factors for severe acute pancreatitis (SAP) in HTGP patients. Material/Methods A total of 1005 patients with acute pancreatitis (AP) admitted to Peking Union Medical College Hospital (PUMCH) from 1 Jan 2013 to 1 Aug 2018 were retrospectively reviewed. After screening, we enrolled 159 patients with HTGP and 172 with non-hypertriglyceridemia pancreatitis (NHTGP). We gathered and assessed demographic and blood biochemical information and analyzed the risk factors for SAP. Results Age, serum amylase (AMY), lipase (LIP), and serum ionized calcium (Ca 2+ ) in the HTGP group were lower than in the NHTGP group ( P <0.05), while high-sensitivity C-reactive protein (hsCRP), neutrophil–lymphocyte ratio (NLR), and body mass index (BMI) in the HTGP group were higher than in the NHTGP group ( P <0.05). Among the HTGP patients, the results indicated that Ca 2+ (OR=0.018, P <0.001, 95%CI: 0.002–0.129) was an independent protective factor for SAP, while higher CRP (OR=1.008, P =0.004, 95%CI: 1.003–1.013), NLR (OR=1.314, P <0.001, 95%CI: 1.161–1.488), and BMI (OR=1.597, P =0.002, 95%CI: 1.195–2.314) were independent risk factors for SAP. Conclusions Patients with HTGP had lower serum Ca 2+ and higher hsCRP, NLR, and BMI, and these were associated with higher risk of developing SAP.

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Section: Introductionmentioning

confidence: 99%

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Jin

et al. 2019

Med Sci Monit

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“…What's more, we wanted to look into the effects of LMWH in different stages of SAP. According to our experience and other experiment results, 24,45 we then thought an inflammatory reaction of pancreatic tissue occurred 1 h after the induction of pancreatitis and could be regarded as the initial stage of SAP; 6 h after the induction of pancreatitis could be considered as the development stage of SAP; 12 h after the induction of pancreatitis was the most severe. Moreover, 6 h and 12 h were the generally accepted time points for performing experiments of SAP.…”

Section: Discussionmentioning

confidence: 77%

Prophylactic low-molecular-weight heparin administration protected against severe acute pancreatitis partially by VEGF/Flt-1 signaling in a rat model

Zhang

et al. 2020

Hum Exp Toxicol

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Background: The present study was aimed to explore the effects and the underlying mechanism of prophylactic low-molecular-weight heparin (LMWH) treatment on taurocholate-induced severe acute pancreatitis (SAP) in a rat model. Methods: Rat SAP model was induced by injection of 4% sodium taurocholate into the pancreatic duct. LMWH was applied half an hour before the induction of pancreatitis at the dose of 200 IU/kg subcutaneous injection. The rats were euthanized at 1 h, 6 h, and 12 h after taurocholate-induced SAP. The inflammatory and oxidative response markers were assessed. And the vascular endothelial growth factor (VEGF) and Fms-related tyrosine kinase 1 (Flt-1) expression were evaluated by immunohistochemistry (IHC) and western blot methods. Results: The expression of inflammatory and oxidative response markers increased after induction of SAP. IHC and western blot results showed the VEGF and Flt-1 expression were increased in SAP group. Prophylactic LMWH administration reduced the inflammatory and oxidative response markers expression and decreased the expression of VEGF and Flt-1. Conclusions: This study suggested that prophylactic LMWH treatment mitigated the severity of pancreatitis in rat SAP model by anti-inflammation and oxidative response. The underlying mechanism may result from downregulating VEGF/Flt-1 signaling of LMWH in SAP rat model.

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Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

Chen

Wang

Zhao

et al. 2020

International Immunopharmacology

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Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis

Cited by 3 publications

References 30 publications

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Low Serum Ionized Calcium, Elevated High-Sensitivity C-Reactive Protein, Neutrophil-Lymphocyte Ratio, and Body Mass Index (BMI) Are Risk Factors for Severe Acute Pancreatitis in Patients with Hypertriglyceridemia Pancreatitis

Prophylactic low-molecular-weight heparin administration protected against severe acute pancreatitis partially by VEGF/Flt-1 signaling in a rat model

Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

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