Serum thyroglobulin (Tg) concentration in healthy subjects: Absence of age- and sex-related differences.

Nakamura, Shigenori; Sakata, Shigeki; Minamori, Yoshiaki; Komaki, Takashi; Kojima, Naoto; Kamikubo, Keita; Miura, Kiyoshi

doi:10.1507/endocrj1954.31.93

Cited by 9 publications

(12 citation statements)

References 16 publications

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“…This suggests that there may be little independent effect of age, but that the agerelated increase in serum Tg may simply be reflecting the increase in thyroid abnormalities. It is consistent with the reports of no age-related differences in serum Tg in iodinesufficient areas (39), where the prevalence of goitre is relatively constant with age.…”

Section: Discussionsupporting

confidence: 92%

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Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Knudsen

Bülow

Jørgensen

et al. 2001

The Journal of Clinical Endocrinology & Metabolism

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Serum Tg is widely used in the control of thyroid cancer but also in the diagnosis of certain other thyroid diseases. Serum Tg may be useful in the characterization of the iodine status of a population, but little is known about determinants of serum Tg levels. We examined a random selection of 4,649 subjects from 2 regions in Denmark with different iodine status. Thyroid volume and structure were determined with ultrasonography, and thyroid function tests and Tg analysis were performed. The factor with the closest association with serum Tg levels was thyroid volume at ultrasonography (P < 0.001). Also thyroid nodularity (P < 0.001) and iodine excretion (P < 0.001) had close associations to serum Tg, even after adjusting for the influence of the other parameters. Thyroid dysfunction had a less pronounced but still highly significant association with serum Tg (P < 0.001), but no relation was found to serum TSH in general. The association with age seemed to rely on differences in the prevalence of thyroid abnormalities, and men had lower Tg levels than women of the same age. There was a marked difference in serum Tg between the two regions with slightly different iodine excretion also after adjusting for the other factors. In conclusion, serum Tg reflects thyroid abnormalities and thyroid function and is a sensitive marker of iodine deficiency in a population.

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Section: Discussionsupporting

confidence: 92%

“…Controversy exists about the influence of age and gender on serum Tg, as discussed by Feldt-Rasmussen (36,38,39). We found clearly lower levels of serum Tg in men, also after correcting for the difference in thyroid abnormalities.…”

Section: Discussionmentioning

confidence: 44%

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Knudsen

Bülow

Jørgensen

et al. 2001

The Journal of Clinical Endocrinology & Metabolism

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“…In iodine deficiency, an increased amount of Tg is released into the blood (20), which is positively correlated with thyroid volume (21). For example, healthy adults have a mean Tg concentration ranging from 5 to 14 lg/L (22)(23)(24)(25)(26)(27). In contrast, adults with endemic goiter have a mean Tg ranging from 94 to 208 lg/L (28)(29)(30).…”

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confidence: 99%

Thyroglobulin as a Biomarker of Iodine Deficiency: A Review

Feei

Skeaff²

2014

Thyroid

135

113

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Background: Thyroglobulin, produced exclusively by the thyroid gland, has been proposed to be a more sensitive biomarker of iodine status than thyrotropin or the thyroid hormones triiodothyronine and thyroxine. However, evidence on the usefulness of thyroglobulin (Tg) to assess iodine status has not been extensively reviewed, particularly in pregnant women and adults. Summary: An electronic literature search was conducted using the Cochrane CENTRAL, Web of Science, PubMed, and Medline to locate relevant studies on Tg as a biomarker of iodine status. Since urinary iodine concentration (UIC) is the recommended method to assess iodine status in populations, only studies that clearly reported both Tg and UIC were included. For the purpose of this review, a median Tg <13 lg/L and a median UIC ‡100 lg/L (UIC ‡150 lg/L for pregnant women) were used to indicate adequate iodine status. We excluded studies conducted in subjects with either known thyroid disease or those with thyroglobulin antibodies. The search strategy and selection criteria yielded 34 articles of which nine were intervention studies. The majority of studies (six of eight) reported that iodine-deficient pregnant women had a median Tg ‡13 lg/L. However, large observational studies of pregnant women, including women with adequate and inadequate iodine status, as well as well-designed intervention trials that include both Tg and UIC, are needed. In adults, the results were equivocal because iodine-deficient adults were reported to have median Tg values of either <13 or ‡13 lg/L. Only studies in school-aged children showed that iodine-sufficient children typically had a median Tg <13 lg/L. Some of the inconsistent results may be partially explained by the use of different methodological assays and failure to assess assay accuracy using a certified reference material. Conclusions: These data suggest that Tg does hold promise as a biomarker of iodine deficiency. However, it is associated with limitations. A median Tg cutoff of 13 lg/L warrants further investigation, particularly in adults or pregnant women, as there is a lack of both observational and intervention studies in these groups.

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“…Therefore, it is not clear whether the levels of serum Tg in pregnant women can be used in the assessment of the clinical states of thyroidal disorders. subjects showed an approximately normal distribution in the logarithmic scale (Van Herle et al, 1976;Nakamura et al, 1984). The Mann and Whitney U test was per formed using the native values for Tg (Pezzino et.…”

mentioning

confidence: 99%

“…The Mann and Whitney U test was per formed using the native values for Tg (Pezzino et. al., 1977;Nakamura et al, 1984). Differences were considered to be significant if p was less than 0.05.…”

mentioning

confidence: 99%

Serum thyroglobulin concentration in normal pregnancy.

et al. 1984

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We measured the levels of serum thyroglobulin (Tg) in 52 pregnant females at various stages and compared them with those of 15 age-matched nonpregnant females. Serum Tg was measured by a solid-phase immunoradiometric assay. In pregnant females, mean serum Tg levels at the first, second, early third, and late third trimesters were 8.4 (range; 1.3-18.0), 9.2 (1.7-25.6), 10.1 (1.8-22.8), and 12.1ng/ml (5.3-25.2), respectively. The statistical comparison was made after logarithmic transformation of the data. The mean value only at the late third trimester was significantly higher than that of controls (mean; 6.0ng/ml, range; 1.5-23.6), but each value was within the normal range. Although serum Tg levels have been reported to be high at the end of pregnancy, our results indicate that the Tg levels in females could be clinically interpreted without regard to the coexistence of pregnancy.

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Serum thyroglobulin (Tg) concentration in healthy subjects: Absence of age- and sex-related differences.

Cited by 9 publications

References 16 publications

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Thyroglobulin as a Biomarker of Iodine Deficiency: A Review

Serum thyroglobulin concentration in normal pregnancy.

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