Serum Thyroglobulin in Patients With Autonomous Thyroid Nodules

Madeddu, Giordano; Casu, Anna; Marrosu, Antonio; Marras, G; Langer, M.

doi:10.1111/j.1365-2265.1984.tb03224.x

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…It is thus import¬ ant to study other indexes of thyroid status which are not influenced by TBG or albumin. As serum thyroglobulin (Tg) levels have been reported to correlate with thyroid status , 1975Madeddu et al 1984), we followed the serum Tg levels during normal pregnancy in order to see whether they would decrease with the FT4 levels or not.…”

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confidence: 99%

Decreased serum thyroglobulin levels in the late stage of pregnancy

Hara¹,

Tanikawa²,

Sakatsume³

et al. 1986

Acta Endocrinologica

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Serum thyroglobulin levels were serially measured in 25 normal pregnant women to evaluate thyroidal activity during normal pregnancy. Measurements included serum T3, T4, free T4, TBG, and TSH.Tg and FT4 levels were found to be decreased in the third trimester when compared with those of the first trimester and with those of normal non-pregnant individuals (P < 0.01). TSH levels were higher than normal in pregnant women at all stages of pregnancy, with a significant rise at the third trimester. These findings suggest the presence of a subclinical hypothyroid state in the late stage of normal pregnancy.It has been reported that the levels of serum free thyroxine (FT4) and free 3,5,3'-triiodothyronine (FT3), measured by the classic equilibrium dialysis method (Sterling & Brenner 1966;Weeke et al. 1982) and the recent analog-type radioimmuno¬ assay (RIA, Franklyn et al. 1983a,b;Smith & Bold 1983), are decreased in the late stage of normal pregnancy. However, the clinical significance of these findings has not been clarified, since preg¬ nant women show none of the clinical features of hypothyroidism, and the results of these RIAs have been shown to be influenced by serum albu¬ min levels (Stockigt et al. 1982;Amino et al. 1983; Midgley & Wilkins 1983), which to some extent may change during pregnancy. It is thus import¬ ant to study other indexes of thyroid status which are not influenced by TBG or albumin. As serum thyroglobulin (Tg) levels have been reported to correlate with thyroid status , 1975Madeddu et al. 1984), we followed the serum Tg levels during normal pregnancy in order to see whether they would decrease with the FT4 levels or not. Materials and MethodsTwenty-live normal pregnant women with no previous history of thyroid diseases and no anti-thyroid anti¬ bodies in their sera were followed for the entire period of pregnancy. Blood was drawn at the first trimester (5-19 weeks), the second trimester (26-29 weeks), and the third trimester (35 -37 weeks). The sera were stored at -20°C.

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confidence: 99%