1986
DOI: 10.1530/acta.0.1130418
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Decreased serum thyroglobulin levels in the late stage of pregnancy

Abstract: Serum thyroglobulin levels were serially measured in 25 normal pregnant women to evaluate thyroidal activity during normal pregnancy. Measurements included serum T3, T4, free T4, TBG, and TSH.Tg and FT4 levels were found to be decreased in the third trimester when compared with those of the first trimester and with those of normal non-pregnant individuals (P < 0.01). TSH levels were higher than normal in pregnant women at all stages of pregnancy, with a significant rise at the third trimester. These findings s… Show more

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Cited by 13 publications
(10 citation statements)
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“…Although there still is some discussion about thyroid function during late pregnancy, we cannot confirm the observations of Hara et al 20 about the low TSH in pregnancy and we conclude in accordance with others8.21.22 that the TSH level is normal in late pregnancy and reflects the euthyroid state of these subjects.…”
Section: Clinical Performancecontrasting
confidence: 79%
“…Although there still is some discussion about thyroid function during late pregnancy, we cannot confirm the observations of Hara et al 20 about the low TSH in pregnancy and we conclude in accordance with others8.21.22 that the TSH level is normal in late pregnancy and reflects the euthyroid state of these subjects.…”
Section: Clinical Performancecontrasting
confidence: 79%
“…These studies have all been characterized by the lack of a longitudinal design and adequate control groups. Hara and coworkers (8) investigated 25 women during pregnancy using a longitudinal de¬ sign and comparisons with non-pregnant agematched females and found a decrease in serum Tg level during pregnancy. In the latter study no post¬ partum follow-up was, however, included.…”
Section: Discussionmentioning
confidence: 99%
“…Pregnancy and the postparlum period involve substantial variations in thyroid function as well as thyroid size (2) although il is generally agreed lhat healthy women are euthyroid during this period. No sludies of serum Ihyroglobulin (Tg) during ihe menslrual cycle are available and pregnancy-re¬ lated alterations of serum Tg have been controver¬ sial (3)(4)(5)(6)(7)(8). In view of ihe increasing use of serum Tg in differenl thyroid disorders and in the follow-up of patients with differentiated thyroid carcinoma we have found it of inleresl to investigate the in¬ fluence of ihese physiologic factors on serum Tg in heallhy women.…”
mentioning
confidence: 99%
“…In a study by Eltom et al (41), serum Tg, TSH, and urinary iodine concentrations were measured in 27 healthy pregnant Swedish women and in 21 Sudanese women. The median Tg levels in the pregnant Swedish women were 15.5 in the first, 10.5 in the second, and 18.0 g/liter in the third trimester.…”
Section: The Utility Of Tg Measurement During Pregnancymentioning
confidence: 99%