Serum Thiol/Disulphide Homeostasis in Preeclampsia

Özler, Sibel; Erel, Özcan; Öztaş, Efser; Ersoy, Ali Özgür; Ergin, Merve; Sucak, Ayhan; Neşeli̇oğlu, Salim; Uygur, Dilek; Danışman, Nuri

doi:10.3109/10641955.2015.1077859

Cited by 34 publications

(18 citation statements)

References 21 publications

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“…It has been demonstrated that TDH was shifted in favor of oxidative status in preeclampsia, pregnant women diagnosed with idiopathic recurrent pregnancy loss, pregnant women diagnosed with Familial Mediterranean fever, pregnant women with fetal neural tube defects and vaginitis patients [89][90][91][92][93].…”

Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Obstetric and Gynecologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…Demonstrating the destructive effects of oxidative stress can elicit valuable information in terms of understanding the biochemical process involved in many diseases [14][15][16]. The TDH measurement method newly developed by Erel et al [8,15,[17][18][19][20][21][22] has been shown to a reliable indicator in showing oxidative stress.…”

Section: The European Research Journal Volume 5 Issue 2 March 2019mentioning

confidence: 99%

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Eroğlu

Badem

Baççıoğlu

et al. 2019

The European Research Journal

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Objectives: The severity of inflammation occurring during chronic obstructive pulmonary disease (COPD) is closely associated with oxidative stress. The aim of this study was to investigate the diagnostic value of Thiol/disulphide homeostasis (TDH) and ischemia modified albumin (IMA) levels in evaluating oxidative stress in COPD patients. Methods: This prospective study was performed with COPD patients presenting to the Kırıkkale University Hospital and with healthy volunteers. Subjects' demographic data (age, sex, body mass index, and smoking status), native thiol (NT), total thiol (TT), disulphide (Ds), IMA levels and Ds/NT, Ds/TT and NT/TT ratios were recorded. Statistical analysis was performed with SPSS 21.0 software. Results: One hundred ninety subjects were enrolled in the study, 141 COPD patients and 49 healthy volunteers. No difference was determined between the patient and control groups in terms of age, sex or body mass index. The antioxidant markers; NT and TT levels and NT/TT ratio were significantly lower in the patient group compared to the control group (p < 0.001, p < 0.001, and p < 0.003, respectively). The oxidant markers; IMA levels and Ds/NT and Ds/TT ratios were significantly higher in the patient group (p = 0.006, p = 0.003, and p = 0.003, respectively). Significant negative correlation was determined between antioxidant and oxidant parameters. Sensitivity values were NT: 87.2%, TT: 83.3%, Ds/NT ratio: 68.1%, Ds/TT ratio: 68.1%, and IMA: 77.8%. Conclusions: TDH was impaired in favor oxidants in COPD patients. TDH parameters and IMA can be used to monitor oxidative stress emerging in COPD.

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“…[25] Serum total thiols as a marker of oxidative stress, have been studied in various systemic diseases like ischaemic heart disease, diabetes, pulmonary diseases, Alzheimer's disease, preeclampsia, kidney diseases and alcoholism. [26,27,28,29,30,31,32,33] Serum thiols have also been studied in ophthalmic diseases like keratoconus, pseudo exfoliation syndrome and cataract. [34,35,36] As regards thiol levels in CSCR, thorough review of scientific periodicals yielded only two studies in Turkish population, that assessed total thiol in CSCR, of which only one was done in acute CSCR.…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Total Thiol Levels and Lipid Peroxidation as Indicator of Oxidative Stress in Patients of Acute Central Serous Retinopathy

Bandopadhyay¹,

Mandal²,

Sarkar³

2019

jemds

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BACKGROUND ''Central Serous Retinopathy (CSCR) is an idiopathic, commonly encountered retinal disease, in which stress has been implicated to play a possible role. Our study aimed to determine the role of oxidative stress in the pathogenesis of the disease by comparing the serum levels of total thiols and TBARS in patients of CSCR and normal controls.'' The aim of this study was to determine the level of plasma total thiol and malondialdehyde (MDA) in patients of central serous chorioretinopathy (CSCR) and compare these parameters with that of normal individuals to evaluate the relevance of oxidative stress in the disease pathogenesis. MATERIALS AND METHODS A prospective cross-sectional study was performed that included 30 patients of CSCR and 30 normal patients as controls. Serum total thiol and malondialdehyde levels were measured and compared between the two groups. Correlation between serum total thiol and malondialdehyde with best corrected visual acuity, central minimum macular thickness at the foveola (CMT) and average macular thickness (AMT) was done using Pearson's correlation coefficient. RESULTS Serum total thiol levels were lower (370.9+53.34 mM) compared to the control group (761.5+25.44 mM), with p<0.01. Serum MDA levels were higher (7.52 + 0.68 µM) than the control group (2.03+0.112 µM), with p value <0.01. In CSCR, correlation analysis tests showed a strong positive correlation (p<0.05) between the elevated levels of MDA with CMT (r = 0.377) and AMT (r =0.398) and a very strong negative correlation (p<0.01) between serum total thiol levels with CMT (r =-0.834) and AMT (r =-0.73). Regression analysis showed that a decrease in total thiol levels can be a strong predictor (beta-0.811) of increase in CMT in CSCR (p<0.01) while increase in MDA levels is not a significant predictor (beta 0.057). The overall model fit was adjusted R 2 =0.675 (p<0.01). CONCLUSION A higher level of total thiol and a lower level of MDA were found in CSCR as compared with normal controls. Total thiols can be useful in the prediction and diagnosis of the severity of CSCR.

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Serum Thiol/Disulphide Homeostasis in Preeclampsia

Abstract: Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.

Cited by 34 publications

References 21 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Significance of thiol/disulphide homeostasis and ischemia modified albumin levels in chronic obstructive pulmonary disease

Study of Serum Total Thiol Levels and Lipid Peroxidation as Indicator of Oxidative Stress in Patients of Acute Central Serous Retinopathy

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