Serum sulfonylurea receptor-1 as a biomarker of clinical severity and prognosis in patients with traumatic brain injury

Xiang, Ying; Chen, Maosong; Zhang, Jie; Sun, Congjian; Zhou, Jiang

doi:10.1016/j.cca.2022.01.018

Cited by 3 publications

(6 citation statements)

References 24 publications

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“…17 , 18 Also, serum SUR1 levels were substantially increased in patients with aneurysmal subarachnoid hemorrhage 19 or moderate to severe traumatic brain injury. 20 In line with the preceding studies, 17–20 our study confirmed that ICH patients had substantially higher serum SURE1 levels than healthy individuals. Overall, it is hypothesized that SUR1 in peripheral blood of ICH patients may at least in part be derived from injured brain tissues.…”

Section: Discussionsupporting

confidence: 92%

“…17–19 Of note, in a clinical study of 100 healthy controls and 138 patients with moderate to severe traumatic brain injury, rising serum SUR1 levels were intimately related to disease severity and independently predicted poor prognosis after traumatic brain injury. 20 Alternatively, our study enrolled 131 patients and 131 healthy controls and found that rising serum SUR1 levels were highly correlated with hemorrhagic severity indicated by NIHSS score, GCS score, hematoma volume and ICH score, as well as were independently associated with END and poor outcome at 90 days after ICH; moreover, this biomarker displayed similar predictive capability, as compared to NIHSS score, GCS score, hematoma volume and ICH score. Taken together, serum SUR1 may represent a potential biomarker of ICH.…”

Section: Discussionmentioning

confidence: 82%

“… 19 Although those studies enrolled a small number of patients (≤44 cases) and did not use multivariate analyses, 17–19 a more recent study recruited 100 healthy controls and 138 patients with moderate to severe traumatic brain injury and found that elevated serum SUR1 levels, in close correlation with traumatic severity, were independently associated with poor prognosis after traumatic brain injury. 20 The preceding data have indicated that serum SUR1 may be a potential prognostic biomarker of diseases with acute brain injury.…”

Section: Discussionmentioning

confidence: 99%

“… 19 A more recent study has showed the close relationship between serum SUR1 levels and traumatic severity plus 3-month poor neurological outcome of patients with moderate to severe traumatic brain injury. 20 Overall, serum SUR1 may be a potential prognostic biomarker of acute brain injury. In this study, we recruited a group of ICH patients and attempted to determine whether serum SUR1 levels are correlated with hemorrhagic severity and clinical outcomes after stroke.…”

Section: Introductionmentioning

confidence: 99%

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Serum Sulfonylurea Receptor-1 Levels After Acute Supratentorial Intracerebral Hemorrhage: Implication for Prognosis

Zhuge¹,

Zhan²,

Wang³

et al. 2022

NDT

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Objective Sulfonylurea receptor-1 (SUR1) is implicated in acute brain injury. This study was designed to determine relationship between serum SUR1 levels and severity, early neurologic deterioration (END) plus clinical outcome after intracerebral hemorrhage (ICH). Methods Serum SUR1 levels of 131 ICH patients and 131 healthy controls were quantified in this prospective, observational study. END was defined as an increase of 4 or more points in the National Institutes of Health Stroke Scale (NIHSS) score or death within 24 hours after admission. Patients with a modified Rankin scale (mRS) score of 3–6 at 90 days following onset were considered to experience a poor outcome. Results Serum SUR1 levels were substantially higher in patients than in controls. Serum SUR1 levels of patients were highly correlated with NIHSS score, Glasgow Coma Scale score, hematoma volume and ICH score. Compared with patients with END or mRS score of 0–2, other remainders had significantly elevated serum SUR1 levels. Serum SUR1 levels independently predicted END and 90-day poor outcome. Under receiver operating characteristic curve, serum SUR1 levels significantly predicted END and a poor outcome at 90 days after hemorrhagic stroke and its predictive value was similar to those of NIHSS score, Glasgow coma scale score, hematoma volume and ICH score. Conclusion Serum SUR1 levels are highly correlated with severity, END and poor outcome after hemorrhagic stroke, indicating that serum SUR1 may be useful for risk stratification and prognostic prediction of ICH.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Sulfonylurea Receptor-1 Levels After Acute Supratentorial Intracerebral Hemorrhage: Implication for Prognosis

Zhuge¹,

Zhan²,

Wang³

et al. 2022

NDT

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“…Previous reports found serum Sur1 levels and cerebrospinal uid(CSF) Sur1 levels may be related to traumatic severity and clinic prognosis of patients with traumatic brain injury [32][33][34]. An article involves serum Sur1 levels may be associated with functional outcome of patients with aneurysmal subarachnoid hemorrhage [26].…”

Section: Sur1 Trpm4 and Mmp-9 Temporal Pro Lementioning

confidence: 99%

Serum sulfonylurea receptor-1 is correlation to perihematomal edema after intracerebral hemorrhage and as a biomarker of clinical prognosis in patients with intracerebral hemorrhage

Huang

Liu

et al. 2022

Preprint

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Background Sulfonylurea receptor-1(Sur1) and transient receptor potential melastatin 4(Trpm4) are implicated in acute brain injury. We determine whether serum Sur1 and Trpm4 concentrations are associated with spontaneous intracerebral hemorrhage(ICH) related perihematomal edema(PHE) and clinical outcome after ICH. Methods Serum Sur1 and Trpm4 concentrations were measured in 51 healthy controls and 51 patients with ICH. modified Rankin Scale (mRS) score and non-contrast computed tomography (NCCT) were recorded to assess perihematomal edema (PHE) severity. Modified Rankin Scale(mRS) score of 4–6 at 3 months after ICH was defined as an unfavorable outcome. Results Serum Sur1 and Trpm4 concentrations were substantially higher in patients with ICH than in controls. Peak PHE volume was positively correlated with baseline Sur1(r = 0.302, p = 0.031) and more significant related to peak Sur1(0.346, 0.013). Under receiver operating characteristic curve, peak Sur1 levels remained as an independent predictor of poor outcome (OR1.574, 95% CI, 1.144 to 2.165). Conclusions Elevated serum Sur1 levels are related to PHE severity and are independently associated with poor prognosis after ICH, indicating that serum Sur1 may have the potential to be a prognostic biomarker of ICH.

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The Relationship between Serum SUR1 Level and the Severity and Prognosis of Cerebral Edema after Hypertensive Intracerebral Hemorrhage

黄¹

2023

ACM

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Serum sulfonylurea receptor-1 as a biomarker of clinical severity and prognosis in patients with traumatic brain injury

Cited by 3 publications

References 24 publications

Serum Sulfonylurea Receptor-1 Levels After Acute Supratentorial Intracerebral Hemorrhage: Implication for Prognosis

Serum Sulfonylurea Receptor-1 Levels After Acute Supratentorial Intracerebral Hemorrhage: Implication for Prognosis

Serum sulfonylurea receptor-1 is correlation to perihematomal edema after intracerebral hemorrhage and as a biomarker of clinical prognosis in patients with intracerebral hemorrhage

The Relationship between Serum SUR1 Level and the Severity and Prognosis of Cerebral Edema after Hypertensive Intracerebral Hemorrhage

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