Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens

Sepilian, Vicken; Crochet, John R.; Nagamani, Manubai

doi:10.1016/j.fertnstert.2005.10.038

Cited by 42 publications

(37 citation statements)

References 58 publications

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“…The strong linear correlation between BMI and leptin, observed in this and previous studies (10), demonstrates that adiposity may represent the main determinant of leptin levels in females with PCOS, as in the general population. In the present study, serum leptin and insulin levels are linked to obesity, suggesting their role in the complicated picture of the syndrome in patients with obesity.…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

The Effects of Raw Red Onion Consumption on Serum Levels of Adiponectin, Leptin, and hs-CRP in Overweight/Obese Females with Polycystic Ovarian Syndrome: A Randomized Controlled-Clinical Trial

Saghafi-Asl

Ebrahimi-Mameghani

2017

Iran Red Crescent Med J

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Section: Discussionsupporting

confidence: 80%

“…Serum leptin levels are highly correlated with body fat percentage (9). In PCOS, the main determinant of leptin levels seems to be adiposity rather than IR (10). This may be owing to the dominant effect of the adipose tissue mass on serum leptin levels.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Raw Red Onion Consumption on Serum Levels of Adiponectin, Leptin, and hs-CRP in Overweight/Obese Females with Polycystic Ovarian Syndrome: A Randomized Controlled-Clinical Trial

Saghafi-Asl

Ebrahimi-Mameghani

2017

Iran Red Crescent Med J

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“…Recently, in women with PCOS, which show similarity to patients with CAH elevated androgen levels, there is evidence for decreased serum levels of sOB-R, even though there was no significant correlation with androgen levels themselves (14). By contrast, a second study on the leptin axis in PCOS showed a negative correlation of sOB-R with DHEAS concentration (rZ0.35) (35). In our cohort, we demonstrated a negative correlation of androgens, testosterone, and DHEAS.…”

Section: Discussionmentioning

confidence: 99%

Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency?

Völkl¹,

Simm²,

Körner³

et al. 2009

European Journal of Endocrinology

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Objective: Congenital adrenal hyperplasia (CAH) patients are at a higher risk to develop obesity. The role of leptin in CAH is still controversial. Our study aimed to evaluate serum levels of leptin, the soluble leptin receptor (sOB-R), and the sOB-R: leptin molar ratios in a cohort of CAH children and adolescents, and their associations with clinical and metabolic parameters. Methods: We studied 51 CAH patients, aged 5.6-19.6 years (median 11.8, nZ30 females) crosssectionally. All patients had genetically proven CAH and received standard steroid substitution therapy. Blood specimens were taken after overnight fasting between 0800 and 1000 h. For the analyses of leptin and sOB-R, matched pairs were built with healthy Caucasian patients for sex, Tanner stage (TS), chronologic age (CA), and body mass index (BMI). Results: BMI and SDS were significantly elevated compared with the reference population. Leptin levels were not different between matched pairs, whereas sOB-R levels were significantly lower in CAH. Consequently, the sOB-R: leptin molar ratios were significantly decreased in CAH. Correlation analyses in CAH patients revealed significant relationship between leptin and CA, TS, BMI, and homeostasis model assessment of insulin resistance. Similar results were obtained for the matched control group. For sOB-R, we found no significant correlation for CA, TS, or BMI in CAH, but we did in the controls. There were significant correlations for androgens within the CAH group. Additional analyses revealed no correlation with steroid medication or metabolic control. Conclusions: Our data show that an altered leptin axis with normal serum leptin concentrations but decreased sOB-R serum levels may contribute to the increased risk of overweight and obesity in CAH.

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“…Leptin circulates freely and bound to its soluble receptor (soluble leptin receptor, sOB-R), which affects its bioavailability. The proportion of leptin bound to sOB-R is related to changes in adiposity, with free leptin more accurately reflecting body fat mass [19]. Circulating levels of leptin increase and sOB-R levels decrease during pubertal development, resulting in an increase in free leptin [20].…”

Section: Introductionmentioning

confidence: 99%

Increased Leptin/Adiponectin Ratio and Free Leptin Index Are Markers of Insulin Resistance in Obese Girls during Pubertal Development

Donoso

Muñoz-Calvo²,

Barrios³

et al. 2013

Horm Res Paediatr

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Background: Modifications in body fat in obese patients during puberty determine changes in adipokines that affect insulin sensitivity. Aims: We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) during pubertal development. Methods: A prospective study of 32 obese girls (OG) and age-matched control girls (CG) was performed. OG were divided into those that maintained a weight loss (WL) of >1 SD of initial body mass index (BMI) (WL group, n = 25) and those without WL (NWL group, n = 7). Oral glucose tolerance tests (OGTT) were performed to evaluate IR. Correlations of adipokines, L/A, and FLI with BMI, waist circumference, percentage of TBF (%TBF) and IR were performed over pubertal development. Results: The L/A ratio and FLI were increased in OG at baseline. Both indexes decreased in the WL group as puberty progressed, with no change in CG or NWL. In the WL group, a correlation between L/A and FLI with OGTT and %TBF, and L/A and homeostasis model assessment (HOMA) was found throughout the study. Conclusion: The L/A ratio and FLI are good markers to follow changes in IR and %TBF after WL during puberty. Insulin more accurately reflects the changes in IR than HOMA.

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Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens

Cited by 42 publications

References 58 publications

The Effects of Raw Red Onion Consumption on Serum Levels of Adiponectin, Leptin, and hs-CRP in Overweight/Obese Females with Polycystic Ovarian Syndrome: A Randomized Controlled-Clinical Trial

The Effects of Raw Red Onion Consumption on Serum Levels of Adiponectin, Leptin, and hs-CRP in Overweight/Obese Females with Polycystic Ovarian Syndrome: A Randomized Controlled-Clinical Trial

Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency?

Increased Leptin/Adiponectin Ratio and Free Leptin Index Are Markers of Insulin Resistance in Obese Girls during Pubertal Development

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