Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis

Xu, Wenbin; Hu, Qian-Hua; Wu, Channi; Fan, Zhikun; Song, Zhangfa

doi:10.1002/brb3.1261

Cited by 8 publications

(6 citation statements)

References 46 publications

(57 reference statements)

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“…Fibrinogen‐like protein 2 is pleotropic protein and has two forms; the first form is mFGL‐2 a potent procoagulant factor which is a cellularly expressed and soluble form sFGL‐2 that has a distinctive function (Xu, Hu, Wu, Fan, & Song, 2019). Previous studies showed in situ expression of fibrinogen‐like protein 2 in hamster epididymis tissue (Nagdasm, Winfrey, & Olson, 2016; Olson, Winfrey, NagDas, & Melner, 2004).…”

Section: Discussionmentioning

confidence: 99%

Soluble Fibrinogen‐like protein 2 plays a role in varicocele induced male infertility

et al. 2020

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Varicocele is the most common cause of male infertility. Several theories have been proposed to explain how varicocele induces infertility. The role of epididymis in male infertility is not fully well established. Fibrinogen‐like protein 2 is one of serine proteases and is a potent coagulant in membranous form and immune‐modulator in soluble form (sFGL‐2) and expressed in the epididymis. There are no previous reports about its possible role in varicocele. This case‐controlled study aimed to evaluate the seminal level of sFGL‐2 in infertile men with varicocele and in men with idiopathic infertility. This study included 85 participants divided into three groups; 25 normal fertile men, 30 infertile men with varicocele and 30 infertile men of idiopathic cause. Clinical examination, Doppler ultrasound, semen analysis and measurement of seminal level of sFGL‐2 were done to all participants. Seminal level of sFGL‐2 was significantly elevated in infertile than normal fertile men. Seminal level of sFGL‐2 showed negative correlations with sperm concentration, motility and normal morphology. Seminal level of sFGL‐2 had a positive correlation with seminal liquefaction time. This study concluded that seminal level of sFGL‐2 is increased in infertile men with idiopathic cause and with varicocele induced infertility and affects seminal liquefaction.

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Section: Discussionmentioning

confidence: 99%

Soluble Fibrinogen‐like protein 2 plays a role in varicocele induced male infertility

et al. 2020

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“…Високий вміст його у сировотці крові корелює з тяжкістю ГП. Може використовуватись як прогностичний маркер перебігу захворювання та розвитку інтоксикаційного делирію при ГП (при вмісті ≥244,6 нг/мл), чутливість тесту становить 79,6%, специфічність -66,7% [66].…”

Section: прогнозування та оцінка ступеня тяжкості гпunclassified

Modern Aspects of Pathogenesis and Diagnosis of Acute Pancreatitis

Kolosovych¹,

Hanol²

2023

Fiziol Zh

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Early adequate treatment of patients with acute pancreatitis leads to a decrease in mortality and reduces the financial burden on medical institutions and the patient, which encourages the continued search for optimal markers for assessing severity and predicting the course of the disease. The aim of this work is to study the modern aspects of the pathogenesis of acute pancreatitis and the role of various biomarkers in the diagnosis of the severity of the course of the disease and the prediction of its complications. The study of the features of the pathogenesis of acute pancreatitis continues, which naturally contributes to the emergence of new diagnostic markers of this disease. It has been proven that most of the etiological factors that cause acute pancreatitis (alcohol, hypoxia, hypercalcemia, hyperlipidemia, certain pharmacological drugs) also contribute to abnormally high oscillations of the Ca2+ level. Therefore, it can be assumed that in acute pancreatitis, Ca2+ is a common trigger for various etiological factors, which trigger the pathological process. In turn, the enzymatic cascade is the starting point for the development of local and systemic inflammatory reactions, manifested by local and systemic effects. Based on the study of the features of the course of severe forms of acute pancreatitis, we established the role of vitamin D deficiency in the development of the disease. In addition, the study of the activity of tissue plasminogen activator and/or the level of thrombin-antithrombin III complex can be interesting as markers of the development of thrombohemorrhagic complications. An increase in the number of positive results of a serological examination for Helicobacter pylori (immunoglobulin M) in patients with a severe course of acute pancreatitis after 7 days from the moment of hospitalization gives reason to consider this indicator as one of the predictors of the development of purulent complications of the disease. Preliminary studies using the proposed diagnostic markers give encouraging results regarding the prognosis for the disease and the life of this extremely complex category of patients.

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“…Повышенные сывороточные концентрации этого показателя коррелировали с тяжестью течения деструктивного панкреатита и риском церебральных расстройств [15].…”

Section: областьunclassified

Impact of Demographic Variables on the Risk of Pancreatogenic Encephalopathy in Patients With Nutritional Pancreatonecrosis

Бебуришвили

Mikhin

Burchuladze

et al. 2022

Journal of Volgograd State Medical University

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Resume. Aim. Study of the dependence of the degree of risk of developing pancreatogenic encephalopathy (PEP) on demographic variables in patients with nutritional pancreatic necrosis. Materials and methods. A single-center prospective cohort non-randomized study was conducted on the basis of the Faculty Surgery Clinic of the Volgograd State Medical University in the period from 2010 to 2020. To determine the significance of the influence of a patient-dependent factor on the risk of developing PEP, ROC analysis was used. Logistic regression analysis was used to determine the degree of risk of developing PEP against the background of a combination of several covariates. Results. The study included 429 patients with pancreatic necrosis of alimentary origin. A comparative analysis of the incidence of PEP was carried out depending on gender and age, the trigger of the disease (alcohol-associated versus non-alcoholic pancreatic necrosis) and comorbid background. It has been proven that significant factors that increase the risk of developing PEP are age over 60 years (p = 0,04), alcohol-associated pancreatic necrosis (p < 0,001) and cardiovascular pathology - ischemic heart disease (p < 0,001). A statistically significant regression model of the effect of cardiovascular pathology on the incidence of PEP has been developed, which makes it possible to calculate the risk of this complication in a particular patient. Conclusions. Significant demographic variables that increase the risk of PEP include age over 60 years, alcoholic pancreatitis, and the presence of coronary artery disease in a patient. The developed logistic model makes it possible to calculate the personalized risk of PEP during hospitalization of a patient with nutritional pancreatic necrosis.

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Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis

Cited by 8 publications

References 46 publications

Soluble Fibrinogen‐like protein 2 plays a role in varicocele induced male infertility

Soluble Fibrinogen‐like protein 2 plays a role in varicocele induced male infertility

Modern Aspects of Pathogenesis and Diagnosis of Acute Pancreatitis

Impact of Demographic Variables on the Risk of Pancreatogenic Encephalopathy in Patients With Nutritional Pancreatonecrosis

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